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| 1 | Charcot-Marie-Tooth disease 显示文摘 | Reilly MM Murphy SM Laura M | 2011 | J Peripher Nerv Syst2011，16，1： | 1 |
| 2 | Environmental stress decreases survival, growth, and reproduction in New Zealand mussels显示文摘 | Laura E. Petes Bruce A. Menge Gayle D. Murphy | 2007 | Journal of Experimental Marine Biology and Ecology2007，，1： | 1 |
| 3 | Charcot-Marie-Tooth disease:frequency of genetic subtypes and guidelines for genetic testing显示文摘 | Murphy SM Laura M Fawcett K | 2012 | J Neurol Neurosurg Psychiatry2012，83，7： | 1 |
| 4 | From waste management to knowledge management显示文摘 | Laura Murphy David Heeney | 1999 | Environmental Quality Management1999，，1： | 1 |
| 5 | Variation in the autism candidate gene GABRB3 modulates tactile sensitivity in typically developing children 显示文摘 | Teresa Tavassoli Bonnie Auyeung Laura C Murphy | 2012 | Molecular Autism2012，3，： | 1 |
| 6 | American ginseng in the prevention and treatment of human breast cancer显示文摘 | Laura L Murphy | 2001 | ANSI Std2001，39，18： | 1 |
| 7 | Barrett Esophagus: Prevalence of Central Adiposity, Metabolic Syndrome, and a Proinflammatory State显示文摘 | Aoife M. Ryan Laura A. Healy Derek G. Power Miriam Byrne Sinead Murphy Patrick J. Byrne Dermot Kelleher John V. Reynolds | 2008 | Annals of Surgery2008，，6： | 1 |
| 8 | Barrett Esophagus: Prevalence of Central Adiposity, Metabolic Syndrome, and a Proinflammatory State显示文摘 | Aoife M. Ryan Laura A. Healy Derek G. Power Miriam Byrne Sinead Murphy Patrick J. Byrne Dermot Kelleher John V. Reynolds | 2008 | Annals of Surgery2008，，6： | 1 |
| 9 | American Ginseng in the Prevention and Treatment of Human Breast Caneer显示文摘 | Laura L Murphy | 2001 | ANSI Std2001，39，18： | 1 |
| 10 | Ginseng modifies the diabetic phenotype and genes associated with diabetes in the male ZDF rat显示文摘 | William J. Banz M.J. Iqbal Michael Bollaert Nicole Chickris Bryce James D. Allan Higginbotham Richard Peterson Laura Murphy | 2007 | Phytomedicine2007，，10： | 1 |
| 11 | Evaluation of B-type natriuretic peptide for risk assessment in unstable Angina/Non–ST-elevation myocardial infarction显示文摘 | David A. Morrow James A. de Lemos Marc S. Sabatine Sabina A. Murphy Laura A. Demopoulos Peter M. DiBattiste Carolyn H. McCabe C.Michael Gibson Christopher P. Cannon Eugene Braunwald | 2003 | Journal of the American College of Cardiology2003，，8： | 1 |
| 12 | Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis显示文摘 | Claudia von Montfort Núria Matias Anna Fernandez Raquel Fucho Laura Conde de la Rosa Maria Luz Martinez-Chantar José M. Mato Keigo Machida Hidekazu Tsukamoto Michael P. Murphy Abdellah Mansouri Neil Kaplowitz Carmen Garcia-Ruiz Jose C. Fernandez-Checa | 2012 | Journal of Hepatology2012，，4： | 1 |
| 13 | Adhesive performance of biomimetic adhesive-coated biologic scaffolds显示文摘 | John L Murphy Laura Vollenweider Bruce P Lee | 2010 | Biomacromolecules2010，11，11： | 1 |
| 14 | Carbohydrates blended with polydextrose lower gas production and short-chain fatty acid production in an in vitro system显示文摘 | Brittany M. Vester Boler David C. Hernot Thomas W. Boileau Laura L. Bauer Ingmar S. Middelbos Michael R. Murphy Kelly S. Swanson George C. Fahey | 2009 | Nutrition Research2009，，9： | 1 |
| 15 | HIV-Related Stigma among People with HIV and their Families: A Qualitative Analysis显示文摘 | Laura M. Bogart Burton O. Cowgill David Kennedy Gery Ryan Debra A. Murphy Jacinta Elijah Mark A. Schuster | 2008 | AIDS and Behavior2008，，2： | 1 |
| 16 | Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine显示文摘AIM To identify mi RNA-regulated proteins differentially expressed between Caco2 and HT-29: two principal cell line models of the intestine.METHODS Exponentially growing Caco-2 and HT-29 cells were harvested and prepared for m RNA, mi RNA and proteomic profiling. m RNA microarray profiling analysis was carried out using the Affymetrix Gene Chip Human Gene 1.0 ST array. mi RNA microarray profiling analysis was carried out using the Affymetrix Genechip mi RNA 3.0 array. Quantitative Label-free LC-MS/MS proteomic analysis was performed using a Dionex Ultimate 3000 RSLCnano system coupled to a hybrid linear iontrap/Orbitrap mass spectrometer. Peptide identities were validated in Proteome Discoverer 2.1 and were subsequently imported into Progenesis QI software for further analysis. Hierarchical cluster analysis for all three parallel datasets(mi RNA, proteomics, m RNA) was conducted in the R software environment using the Euclidean distance measure and Ward's clustering algorithm. The prediction of mi RNA and oppositely correlated protein/m RNA interactions was performed using Target Scan 6.1. GO biological process, molecular function and cellular component enrichment analysis was carried out for the DE mi RNA, protein and m RNA lists via the Pathway Studio 11.3 Web interface using their Mammalian database.RESULTS Differential expression(DE) profiling comparing the intestinal cell lines HT-29 and Caco-2 identified 1795 Genes, 168 Proteins and 160 mi RNAs as DE between the two cell lines. At the gene level, 1084 genes were upregulated and 711 were downregulated in the Caco-2 cell line relative to the HT-29 cell line. At the protein level, 57 proteins were found to be upregulated and 111 downregulated in the Caco-2 cell line relative to the HT-29 cell line. Finally, at the mi RNAs level, 104 were upregulated and 56 downregulated in the Caco-2 cell line relative to the HT-29 cell line. Gene ontology(GO) analysis of the DE m RNA identified cell adhesion, migration and ECM organization, cellular lipid and cholesterol metabolic processes, small molecule transport and a range of responses to external stimuli, while similar analysis of the DE protein list identified gene expression/transcription, epigenetic mechanisms, DNA replication, differentiation and translation ontology categories. The DE protein and gene lists were found to share 15 biological processes including for example epithelial cell differentiation [P value ≤ 1.81613 E-08(protein list); P ≤ 0.000434311(gene list)] and actin filament bundle assembly [P value ≤ 0.001582797(protein list); P ≤ 0.002733714(gene list)]. Analysis was conducted on the three data streams acquired in parallel to identify targets undergoing potential mi RNA translational repression identified 34 proteins, whose respective m RNAs were detected but no change in expression was observed. Of these 34 proteins, 27 proteins downregulated in the Caco-2 cell line relative to the HT-29 cell line and predicted to be targeted by 19 unique anti-correlated/upregulated micro RNAs and 7 proteins upregulated in the Caco-2 cell line relative to the HT-29 cell line and predicted to be targeted by 15 unique anti-correlated/downregulated micro RNAs.CONCLUSION This first study providing 'tri-omics' analysis of the principal intestinal cell line models Caco-2 and HT-29 has identified 34 proteins potentially undergoing mi RNA translational repression. | Finbarr O’Sullivan Joanne Keenan Sinead Aherne Fiona O’Neill Colin Clarke Michael Henry Paula Meleady Laura Breen Niall Barron Martin Clynes Karina Horgan Padraig Doolan Richard Murphy | 2017 | World Journal of Gastroenterology2017，23，41： | 1 |
| 17 | Deforestation,land use,and women's agricultural activities in the Ecuadorian Amazon显示文摘 | Thapa K K Bilsborrow R E Murphy Laura | 1996 | World Development1996，24，8： | 1 |
| 18 | Adhesive performance of biomimetic adhesive-coatedbiologic scaffolds 显示文摘 | JohnL Murphy Laura Vollenweider Fangmin Xu | 2010 | Biomacromolecules2010，11，： | 1 |
| 19 | Coupling climate and hydrological models: Interoperability through Web Services显示文摘 | Jonathan L. Goodall Kathleen D. Saint Mehmet B. Ercan Laura J. Briley Sylvia Murphy Haihang You Cecelia DeLuca Richard B. Rood | 2013 | Environmental Modelling and Software2013，，： | 1 |
| 20 | Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes显示文摘 | Marc S Sabatine David A Morrow Christopher P Cannon Sabina A Murphy Laura A Demopoulos Peter M DiBattiste Carolyn H McCabe Eugene Braunwald C.Michael Gibson | 2002 | Journal of the American College of Cardiology2002，，10： | 1 |
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