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| 1 | 口服非洲刺李后人的血清对不同良性前列腺细胞的生物效应显示文摘非洲刺李(太得恩。)是一种普遍用于治疗有症状良性前列腺增生的草药。该药物的活性物质还没有被鉴定出来,因此,确定其血药浓度是不可能的。对该药的疗效目前存在一些争议,因而我们决定用摄入和未摄入非洲刺李的人的血清在体外处理前列腺细胞,观察其对前列腺细胞生长的作用。我们使用的是原代培养和器官培养的良性成纤维(WPMY)前列腺细胞和上皮(PNT2)前列腺细胞。我们也使用了新鲜的良性前列腺组织。研究发现,摄入非洲刺李的人血清可以减少原代培养细胞、器官培养细胞以及WPMY细胞的增殖,但不影响PNT2细胞的增殖。我们还利用AffymetrixHG.U1332.0PLUS芯片分析了处理血清对WPMY细胞基因表达的影响。转录子分析结果显示参与肿瘤抑制通路的多个基因的表达发生了上调,而一些参与炎症及氧化应激通路的基因表达发生了下调。口服非洲刺李可使药物的活性物质达到足够的血清水平,从而抑制成纤维前列腺细胞的增殖。此抑制作用与转录子的改变有关。 | Stephane Larre Philippe Camparo Eva Comperat Delphine Boulbes Mohammed Haddoum Sylvain Baulande Pascal Soularue Pierre Costa Olivier Cussenot | 2012 | Asian Journal of Andrology2012，14，3： | 2 |
| 2 | Initial experience with successful totally robotic laparoscopic cystoprostatectomy and ileal conduit construction in tet-raplegic patients:report of two cases显示文摘 | Hubert J Chammas M Larre S | 2006 | Journal of Endocrinology2006，，02： | 2 |
| 3 | Properties of demidated gluten films enzymatically cross-linked显示文摘 | LARRE C DESSERME C BARBOT J | 2000 | Journal of Agriculture and Food Chemistry2000，48，11： | 1 |
| 4 | Emulsfying and foaming properties of gluten hydrolysates with an increasing degree of hydrosis:role of soluble and insoluble fractions 显示文摘 | Linares E Larre C Lemeste M | 2000 | Cereal Chemistry2000，77，4： | 1 |
| 5 | Properties of demidated gluten films enzymatically cross - linked 显示文摘 | Larre C Desserme C Barbot J | 2000 | Journal of Agriculture Food Chemistry2000，48，： | 1 |
| 6 | PGE2 and LTB4 tissue levels in benign and cancerous prostates 显示文摘 | Larre S Tran N Fan C | 2008 | Prostaglandins Other Lipid Mediat2008，87，14： | 1 |
| 7 | Foaming and Emulsifying Properties of Fractions of Gluten Peptides Obtained by Limit- ed Enzymatic Hydrolysis and Ultrafiltration 显示文摘 | Popineau Y Huehet B Larre C | 2002 | Journal of Cereal Science2002，35，： | 1 |
| 8 | Properties of deamidated gluten films enzymatically cross-linked显示文摘 | Larré C Desserme C Barbot J | | 0，，11： | 1 |
| 9 | Retroperitoneal laparoscopic radical nephrectomy:intermediate oncological results显示文摘 | LarréS Kanso C De La Taille A | 2008 | World J Urol2008，26，： | 1 |
| 10 | Comparison of 5-Fluoro-2'-Deoxyurine with 5-Fluorouracil and their role in the treatment of eolorectal cancer 显示文摘 | Van Larr J Rusturn YM Ackland SP | 1998 | Euro J Cancer1998，34，： | 1 |
| 11 | Final Year Accounting Undergraduates' Attitudes to Group Assessment and the Role of Learning Logs 显示文摘 | Joan Ballantine & Patricia Mccourt Larres | 2007 | Accounting Education: An International Journal2007，16，2： | 1 |
| 12 | Properties of deamidated gluten films enzymatically cross-linked显示文摘 | Larré C Desserme C Barbot J | 2000 | J Agric Food Chem2000，48，： | 1 |
| 13 | Emulsifying and foaming properties of gluten hydrolysates with an increasing degree of hydrolysis : role of soluble and insoluble fractions 显示文摘 | Linares E Larre C Lemeste M | 2000 | Cereal Chemistry2000，77，4： | 1 |
| 14 | Foaming and emulsifying properties of fractions of gluten peptides obtained by limited enzymatic hydrolysis and uhrafiltration 显示文摘 | Popineau Y Huchet B Larre C | 2002 | Journal of Cereal Science2002，35，： | 1 |
| 15 | Association of hrperdense middle,cerebral artery sign with clinical sutcome in patients treated with tisswe pbasminogen activator显示文摘 | Manelfe C Larre V Von Kum mer R | 1999 | Stroke1999，30，4： | 1 |
| 16 | Foaming and emulsifying properties of fractions of gluten peptides obtained by limited enzymatic hydrolysis and ultrafihration 显示文摘 | Popineau Huchet B Larre C Berot S | 2002 | Journal of Cereal Science2002，35，2： | 1 |
| 17 | Reversible cerebral arteriopathy associated with the administration of ergot derivatives显示文摘 | Henry PY Larre P Aupy M | 1984 | Cephalalgia1984，4，3： | 1 |
| 18 | Foaming and emulsifying properties of fractions of gluten peptides obtained by limited enzymatic hydrolysis and ultrafihration 显示文摘 | Popineau Huchet B Larre C Berot S | 2002 | Journal of Cereal Science2002，35，2： | 1 |
| 19 | Biochemical Analysis and Rheological Properties of Gluten Modified by Transglutaminase 显示文摘 | Larre C Denery P S Popineau Y | 2000 | Cereal Chemistry2000，77，2： | 1 |
| 20 | Zika virus infection complicated by GuillainBarrésyndrome-case report,French Polynesia,December 2013显示文摘 | Oehler E Watrin L Larre P Leparc Goffart I Lastere S Valour F Baudouin L Mallet H Musso D Ghawche F | 2014 | Euro Surveill2014，19，20： | 1 |
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