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| 1 | Osteosarcopenia in autoimmune cholestatic liver diseases:Causes,management,and challenges显示文摘Primary biliary cholangitis and primary sclerosing cholangitis(PSC)are the most common cholestatic liver diseases(CLD)in adults and are both characterized by an immune pathogenesis.While primary biliary cholangitis is a model autoimmune disease,with over 90%of patients presenting very specific autoantibodies against mitochondrial antigens,PSC is considered an immune mediated disease.Osteoporosis is the most common bone disease in CLD,resulting in frequent fractures and leading to significant morbidity.Further,sarcopenia is emerging as a frequent complication of chronic liver diseases with a significant prognostic impact and severe implications on the quality of life of patients.The mechanisms underlying osteoporosis and sarcopenia in CLD are still largely unknown and the association between these clinical conditions remains to be dissected.Although timely diagnosis,prevention,and management of osteosarcopenia are crucial to limit the consequences,there are no specific guidelines for management of osteoporosis and sarcopenia in patients with CLD.International guidelines recommend screening for bone disease at the time of diagnosis of CLD.However,the optimal monitoring strategies and treatments have not been defined yet and vary among centers.We herein aim to comprehensively outline the pathogenic mechanisms and clinical implications of osteosarcopenia in CLD,and to summarize expert recommendations for appropriate diagnostic and therapeutic approaches. | Nicola Pugliese Ivan Arcari Alessio Aghemo Andrea G Lania Ana Lleo Gherardo Mazziotti | 2022 | World Journal of Gastroenterology2022，28，14： | 2 |
| 2 | Experience with the determination of LDH-X in seminal plasma as diagnostic and prognostic factor in varicocele显示文摘 | Buonaguidi A Grasso M Lania C | 1993 | Arch Esp Urol1993，46，1： | 1 |
| 3 | Differential role for Sp1/Sp3 transcription factors in the regulation of the promoter activity of multiple cyclin-dependent kinase inhibitor genes显示文摘 | Pagiuca A Gallo P Lania L | 2000 | J Cell Biochem2000，76，3： | 1 |
| 4 | Low-grade left varicocele in patients over 30 years old:the effect of spermatic vein ligation on fertility显示文摘 | Grasso M Lania C Castelli M | | 0，，03： | 1 |
| 5 | Experience with the determination of LDH-X in seminal plasma as diagnostic and prognostic factor in varicocele显示文摘 | Buonaguidi A Grasso M Lania C | 1993 | Arch Esp Urol1993，46，1： | 1 |
| 6 | Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45αgene expression显示文摘 | Amente S Zhang J Lavadera ML Lania L Avvedimento EV Majello B | 2011 | Nucleic Acids Res2011，39，22： | 1 |
| 7 | G-protein and signalling in pituitary tumours显示文摘 | Lania A Spada A | | 0，，12： | 1 |
| 8 | Solitary Fibrous Tumor of The Prostate显示文摘 | Grasso M Blanco S Franzoso F Lania C Bella CDI Crippa S | 2002 | The Journal of Urology2002，168，： | 1 |
| 9 | Preliminary data on biochemical remission of acromegaly after somatostatin analogs withdrawal 显示文摘 | Ronchi CL Rizzo E Lania AG | 2008 | Eur J Endocrinol2008，158，1： | 1 |
| 10 | 2013 Europeanthyroid association guidelines for the diagnosis and treat-ment of thyrotropin-secreting pituitary tumors 显示文摘 | Beck-Peccoz P Lania A Beckers A | 2013 | Eur Thy-roid J2013，2，2： | 1 |
| 11 | Effects of hypothalamicneuropeptides on extracellular signal-regulated kinase(ERK1 andERK2)cascade in human tumoral pituitary cells显示文摘 | Lania A Filopanti M Corbetta S | 2003 | J ClinEndocrinol Metab2003，88，： | 1 |
| 12 | Low-grade left varicocele in patients over 30 years old:the effect of spermatic vein ligation on fertility显示文摘 | Grasso M Lania M Castelli M | | 0，，03： | 1 |
| 13 | 显示文摘 | Ballare E Persani L Lania AG | 2001 | J Clin Endocrinol Metab2001，86，8： | 1 |
| 14 | 2013 European thyroid association guidelines for the diagnosis and treatment of thyrotropin-secreting pituitary tumors显示文摘 | Beck-Peccoz P Lania A Beckers A | 2013 | Eur Thyroid J2013，2，2： | 1 |
| 15 | Pharmacogenetics of D2 dopamine receptor gene in prolactin-secreting pituitary adenomas 显示文摘 | Filopanti M Lania AG Spada A | 2010 | Expert Opin Drug Metab Toxicol2010，6，1： | 1 |
| 16 | Differential role for Sp1/Sp3 transcription factors in the regulation of the promoter activity of multiple cyclin-dependent kinase inhibitor genes显示文摘 | Pagliuca A Gallo P Lania L | 2000 | J Cell Biochem2000，76，3： | 1 |
| 17 | Central hypothyroidism显示文摘 | Lania A Persani L Beck-Peccoz P | 2008 | Pituitaiy2008，11，2： | 1 |
| 18 | Mechanisms of disease:mutations of G proteins and protein-coupled receptors in endocrine diseases显示文摘 | Lania AG Mantovani G Spada A | 2006 | Nat Clin Pract Endocrinol Metab2006，2，12： | 1 |
| 19 | G protein abnormalities in pituitary adenomas 显示文摘 | Spada A Lania A Ballare E | 1998 | Mol Cell Endocrinol1998，142，12： | 1 |
| 20 | Induction of specific phosphodiesterase isoforms by constitutive activation of the cAMP pathway in autonomous thyroid adenomas显示文摘 | Persani L Lania A Alberti L | | 0，，： | 1 |
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