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| 1 | Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses:A multicenter study显示文摘AIM:To evaluate the ability of endoscopic ultrasound(EUS) elastography to distinguish benign from malignant pancreatic masses and lymph nodes.METHODS:A multicenter study was conducted and included 222 patients who underwent EUS examination with assessment of a pancreatic mass(n=121) or lymph node(n=101).The classification as benign or malignant,based on the real time elastography pattern,was compared with the classif ication based on the B-mode EUS images and with the fi nal diagnosis obtained by EUS-guided fi ne needle aspiration(EUS-FNA) and/or by surgical pathology.An interobserver study was performed.RESULTS:The sensitivity and specificity of EUS elastography to differentiate benign from malignant pancreatic lesions are 92.3% and 80.0%,respectively,compared to 92.3% and 68.9%,respectively,for the conventional B-mode images.The sensitivity and specificity of EUS elastography to differentiate benign from malignant lymph nodes was 91.8% and 82.5%,respectively,compared to 78.6% and 50.0%,respectively,for the B-mode images.The kappa coefficient was 0.785 for the pancreatic masses and 0.657 for the lymph nodes.CONCLUSION:EUS elastography is superior compared to conventional B-mode imaging and appears to be able to distinguish benign from malignant pancreatic masses and lymph nodes with a high sensitivity,specificity and accuracy.It might be reserved as a second line examination to help characterise pancreatic masses after negative EUS-FNA and might increase the yield of EUS-FNA for lymph nodes. | Marc Giovannini Botelberge Thomas Bories Erwan Pesenti Christian Caillol Fabrice Esterni Benjamin Monges Geneviève Arcidiacono Paolo Deprez Pierre Yeung Robert Schimdt Walter Schrader Hanz Szymanski Carl Dietrich Christoph Eisendrath Pierre Van Laethem Jean-Luc Devière Jacques Vilmann Peter Saftoiu Andrian | 2009 | World Journal of Gastroenterology2009，15，13： | 48 |
| 2 | New challenges in perioperative management of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of cancer-related death in the industrialized world.Despite progress in the understanding of the molecular and genetic basis of this disease,the5-year survival rate has remained low and usually does not exceed 5%.Only 20%-25%of patients present with potentially resectable disease and surgery represents the only chance for a cure.After decades of gemcitabine hegemony and limited therapeutic options,more active chemotherapies are emerging in advanced PDAC,like 5-Fluorouracil,folinic acid,irinotecan and oxaliplatin and nab-paclitaxel plus gemcitabine,that have profoundly impacted therapeutic possibilities.PDAC is considered a systemic disease because of the high rate of relapse after curative surgery in patients with resectable disease at diagnosis.Neoadjuvant strategies in resectable,borderline resectable,or locally advanced pancreatic cancer may improve outcomes.Incorporation of tissue biomarker testing and imaging techniques into preoperative strategies should allow clinicians to identify patients who may ultimately achieve curative benefit from surgery.This review summarizes current knowledge of adjuvant and neoadjuvant treatment for PDAC and discusses the rationale for moving from adjuvant to preoperative and perioperative therapeutic strategies in the current era of more active chemotherapies and personalized medicine.We also discuss the integration of good specimen collection,tissue biomarkers,and imaging tools into newly designed preoperative and perioperative strategies. | Francesco Puleo Raphaёl Maréchal Pieter Demetter Maria-Antonietta Bali Annabelle Calomme Jean Closset Jean-Baptiste Bachet Jacques Deviere Jean-Luc Van Laethem | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 3 | Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study显示文摘 | Jean-Fran?ois Bosset Gilles Calais Laurent Mineur Philippe Maingon Suzana Stojanovic-Rundic René-Jean Bensadoun Etienne Bardet Alexander Beny Jean-Claude Ollier Michel Bolla Dominique Marchal Jean-Luc Van Laethem Vincent Klein Jordi Giralt Pierre Clavère | 2014 | Lancet Oncology2014，，2： | 2 |
| 4 | Cetuximab in combination with irinotecan/5- fluorouracil/folinic acid (FOLFIRI) in the initialtreatment of metastatic colorectal cancer: a multi-centre two-part phase I / II study显示文摘 | RAOUL J L Van LAETHEM J L PEETERS M | 2009 | BMC Cancer2009，14，9： | 1 |
| 5 | Postoperative adjuvant gemcitabine and concurrent radiation after curative resection of pancreatic head carcinoma: a phase Ⅱ study显示文摘 | Jean-Luc Van Laethem Anne Demols France Gay | 2003 | Int J Radiat Oncol Biol Phys2003，56，4： | 1 |
| 6 | Early and late effects of cardiac resynchronization therapy on exercise-induced mitral regurgitation: relationship with left ventricular dyssynchrony, remodelling and cardiopulmonary performance显示文摘 | MADARIC J VANDERHEYDEN M VAN LAETHEM C | 2007 | Eur Heart J2007，28，17： | 1 |
| 7 | Factors influencing survival at one year in patients with nonbiliary hepatic parenchymal cirrhosis 显示文摘 | Adler M Van Laethem J Glibert A | 1990 | Dig Dis Sci1990，35，1： | 1 |
| 8 | Multisystemic production of interleukin 10 limits the severity of acute pancreatitis in mice显示文摘 | Van Laethem J-L Eskinazi R Louis H | 1998 | Gut1998，43，3： | 1 |
| 9 | Multisystemic production of interleukin 10 limits the severity of acute pancreatitisin mice显示文摘 | van Laethem JL Eskinazi R Louis H | 1998 | Gut1998，43，3： | 1 |
| 10 | Multisystemic production of interleukin 10 limits the severity of acute pancreatitis in mice显示文摘 | Laethem JL Eskinazi R Louis H | 1998 | Gut1998，43，： | 1 |
| 11 | Ultraviolet radiation-induced apoptosis in keratinocytes: on the role of cytosolic factors显示文摘 | Assefa Z Laethem A V Garmyn M | 2005 | Biochim Biophys Acta: Rev Cancer2005，1775，2： | 1 |
| 12 | Clinical impact of biliary drainage and jaundice resolution in patients with obstyuctive metastases at the hilum显示文摘 | Van Laethem J L De Broux S Eisendrath P | 2003 | Am J Gastroenterol2003，98，6： | 1 |
| 13 | N-Acetylcysteine decreases severity of acute pancreatitis in mice 显示文摘 | Demols A Van Laethem JL Quertinmont E | 2000 | Pancreas2000，20，2： | 1 |
| 14 | Comparison of chemoradiotherapy and chemotherapy in patients with a locally advanced pancreatic cancer controlled after 4 months of gem- eitahine with or without erlotinih: final results of the interna- tional phase Ⅲ LAP 07 study 显示文摘 | Hammel P Huguet F Van Laethem J-L | 2013 | J ClinOncol2013，，： | 1 |
| 15 | Multisystemic production of interleukin 10 limits the severity of acute pancreatitis in mice显示文摘 | Eskinazi R Louis H | 1998 | Gut1998，43，： | 1 |
| 16 | Psychosocial work characteristics and sleep quality : asystematic review of longitudinal and intervention research显示文摘 | van Laethem M Beckers DG Kompier M A | 2013 | Scand J Work Env Health2013，39，6： | 1 |
| 17 | Co-incinerationof dried sewage sludge in coal-fi red power plants: a casestudy显示文摘 | Luts D Devoldere K Laethem B | 2000 | Water Science and Technology2000，42，9： | 1 |
| 18 | Oxygen uptake efficiency slope, a new submaximal parameter in evaluating exercise capacity in chronic heart failure patients显示文摘 | Van Laethem C Bartunek J Goethals M | 2005 | Am Heart J2005，149，： | 1 |
| 19 | A p38MAPK/ HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes 显示文摘 | Nys K Van Laethem A Michiels C | 2010 | J Invest Dermatol2010，130，9： | 1 |
| 20 | N-Acetylcysteine decreases severity of acute pancreatitis in mice 显示文摘 | Demols A van Laethem JL Quertinmont E | 2000 | Pancreas2000，20，2： | 1 |
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