维普期刊资源整合服务平台（V6.5）

34篇 您的检索式：作者名="LOUISE M D"

选中清除导出查看参考文献查看引证文献引用追踪共2页首页上一页第1页下一页末页 /2 跳转

	题名	作者	年代	出处	被引量
1	Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival显示文摘AIM: To investigate the function of NOD2 in colonic epithelial cells (CEC). METHODS: A combination of in vivo and in vitro analyses of epithelial cell turnover in the presence and absence of a functional NOD2 protein and, in response to enteric Salmonella typhimurium infection, were used. shRNA interference was also used to investigate the consequences of knocking down NOD2 gene expression on the growth and survival of colorectal carcinoma cell lines. RESULTS:In the colonic mucosa the highest levels of NOD2 expression were in proliferating crypt epithelial cells. Muramyl dipeptide (MDP), that is recognized by NOD2, promoted CEC growth in vitro . By contrast,the growth of NOD2-deficient CECs was impaired. In vivo CEC proliferation was also reduced and apoptosis increased in Nod2-/- mice, which were also evident following enteric Salmonella infection. Furthermore, neutralization of NOD2 mRNA expression in human colonic carcinoma cells by shRNA interference resulted in decreased survival due to increased levels of apoptosis. CONCLUSION: These findings are consistent with the involvement of NOD2 protein in promoting CEC growth and survival. Defects in proliferation by CECs in cases of CD may contribute to the underlying pathology of disrupted intestinal homeostasis and excessive inflammation.	Sheena M Cruickshank Louise Wakenshaw John Cardone Peter D Howdle Peter J Murray Simon R Carding	2008	World Journal of Gastroenterology2008，14，38：	3
2	Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘	Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern	1996	Cell1996，，3：	2
3	The Ten-year Single-center Experience With 6-Mercaptopurine in the Treatment of Inflammatory Bowel Disease显示文摘	Kenneth D Glazier Adam L Palance Louis H Griffel Kiron M Das	2005	Journal of Clinical Gastroenterology2005，，1：	1
4	Management influences no soil microbial communities and their function in botanically diverse hay meadows of northern England and Wales显示文摘	Louise M D Gwyn S G John H	2000	Soil Biology and Biochemistry2000，32，：	1
5	Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism显示文摘	Robertso D M Bickerton A S Louise D A	2005	The American Journal of Clinical Nutrition2005，82，3：	1
6	Management influences no soil microbial communities and their function in botanically diverse hay meadows of northern England and Wales显示文摘	Louise M D Gwyn S G John H	2000	Soil Biol Biochem2000，32，：	1
7	Crystal structure analysis of recombinant rat kidney long chain hydroxy acid oxidase显示文摘	John D B CHEN Zhi-wei	2005	Biochemistry2005，44，：	1
8	Management influences on soil microbial communities and their function in botanically diverse hay meadows of northern England and Wales 显示文摘	LOUISE M D GWYNS G JOHN H	2000	Soil Biol Biochem2000，32，：	1
9	Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412显示文摘	Ellen Weisberg Christina Boulton Louise M Kelly Paul Manley Doriano Fabbro Thomas Meyer D.Gary Gilliland James D Griffin	2002	Cancer Cell2002，，5：	1
10	Living in the Community While Waiting for an Admission in Long-term Care显示文摘	Diane M Louise S Clemence D	2006	J Nuts Care Qual2006，22，：	1
11	Management influences no soil microbial communities and their function in botanically diverse hay mead- ows of northern England and Wales 显示文摘	LOUISE M D GWYN S G JOHN H	2000	Soil Biology and Biochemistry2000，32，：	1
12	Changes in intestinal bifidobacteria levels are associated with the inflammatory response in magnesium-deficient mice显示文摘	BARBARA D P AUDREY M N LOUISE D	2010	J Nutr2010，140，3：	1
13	Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial显示文摘	Alexander GG Turpie Michael R Lassen Bruce L Davidson Kenneth A Bauer Michael Gent Louis M Kwong Fred D Cushner Paul A Lotke Scott D Berkowitz Tiemo J Bandel Alice Benson Frank Misselwitz William D Fisher	2009	The Lancet2009，，9676：	1
14	Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis显示文摘	Ian R van Driel Alan G Baxter Karen L Laurie Tricia D Zwar Nicole L La Gruta Louise M Judd Katrina L Scarff Pablo A Silveira Paul A Gleeson	2002	Autoimmunity Reviews2002，，5：	1
15	Insulin-sensi- tizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism显示文摘	Robertso D M Bickerton A S Louise D A	2005	Am J Clin Nutr2005，，：	1
16	Latent variable models for mixed discrete and continuous outcomes 显示文摘	Mary D S Louise M R Julie M L	1997	Journal of the Royal Statistical Society1997，59，3：	1
17	Vertebrobasilar Disease显示文摘	Sean I Savitz M D Louis R		0，，25：	1
18	Management influences no soil microbial communities and their function in botanically diverse hay meadows of northern England and Wales显示文摘	LOUISE M D GWYN S G JOHN H et ol	2000	Soil Biol Biochem2000，32，：	1
19	Insulin - sensiti- zing effects of dietary resist ant starch and effects on skeletalmuscle and adipose tissuemetabolism显示文摘	Robertso D M Bickerton A S Louise D A	2005	The American Journal of Clinical Nutrition2005，82，3：	1
20	Management influences no soil microbial communities and their function in botanically diverse hay meadows of northern England and Wales显示文摘	LOUISE M D GWYN S G JOHN H	2000	Soil Biol Biochem2000，32，：	1

返回顶部每页显示：

共2页首页上一页第1页下一页末页 /2 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示