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| 1 | Effects and safety of natriuretic peptides as treatment of cirrhotic ascites:A systematic review and meta-analysis显示文摘BACKGROUND Natriuretic peptides are involved in the cascade of pathophysiological events occurring in liver cirrhosis,counterbalancing vasoconstriction and anti-natriuretic factors.The effects of natriuretic peptides as treatment of cirrhotic ascites have been investigated only in small studies,and definitive results are lacking.AIM To examine the effects and safety of natriuretic peptides in cirrhosis patients with ascites.METHODS We searched MEDLINE,Web of Science,Scopus,Cochrane Library and Embase for all available studies applying intravenous administration of any natriuretic peptide to patients suffering from cirrhotic ascites.Inclusion was not limited by treatment duration or dose,or by follow-up duration.Both randomised controlled trials and non-randomised studies were eligible for inclusion.The primary outcome was change in renal sodium excretion.Secondary outcomes included safety measures and changes in renal water excretion,plasma aldosterone concentration,and plasma renin activity.RESULTS Twenty-two studies were included.Atrial natriuretic peptide(ANP)was the only intensively studied treatment.Sodium excretion increased in response to continuous ANP infusion and was more pronounced when infusion rates of>30 ng/kg/min were administered compared with≤30 ng/kg/min(P<0.01).Moreover,natriuresis was significantly higher in study subgroups with mild/moderate ascites compared with moderate/severe and refractory ascites(P<0.01).ANP infusions increased renal water excretion,although without reaching a statistically significant dose-response gradient.Plasma aldosterone concentration and plasma renin activity were significantly lower at baseline in study subgroups achieving a negative sodium balance in response to an ANP administration compared with treatment non-responders(P<0.01).Blood pressure decreases occurred less frequently when ANP doses≤30 ng/kg/min were applied.The quality of evidence for a natriuretic response to ANP was low,mainly due to small sample sizes and considerable between-study heterogeneity.Data were sparse for the other natriuretic peptides;B-type natriuretic peptide and urodilatin.CONCLUSION Intravenous ANP infusions increase sodium excretion in patients with cirrhotic ascites.Continuous infusion rates>30 ng/kg/min are the most effective.However,safety increases with infusion rates≤30 ng/kg/min. | Rasmus Hvidbjerg Gantzel Mikkel Breinholt Kjær Peter Jepsen Niels Kristian Aagaard Hugh Watson Lise Lotte Gluud Henning Grønbæk | 2022 | World Journal of Hepatology2022，14，4： | 1 |
| 2 | Arteriovenous malformations in mice lacking activin roceptor-like kinase-1 显示文摘 | Lisa D Umess BA Lise K | 2000 | Nat Genet2000，26，11： | 1 |
| 3 | Fruit quality and physiological responses of litchi cultivar McLean's Red to 1-methylcyclopropene pre-treatment and controlled atmosphere storage conditions 显示文摘 | Dharini S Lise K | 2010 | LWT-Food Science and Technology2010，43，6： | 1 |
| 4 | Energy consumption and GDP in Turkey:Is there a co-integration relationship?显示文摘 | Lise W Van Montfort K | 2007 | Energy Economics2007，29，6： | 1 |
| 5 | The importance of Notch signaling in peripheral T-cell lymphomas显示文摘 | Maria R? rb? k Kamstrup Edyta Biskup Lise Mette Rahbek Gjerdrum Elizabeth Ralfkiaer Omid Niazi Robert Gniadecki | 2014 | Leukemia & Lymphoma2014，，3： | 1 |
| 6 | Semi-commercial evaluation of Bacillus licheniformis to control mango postharvest diseases in South Africa显示文摘 | Veloshinie G Lise K Dharini S | 2005 | Postharvest Biology and Technology2005，，38： | 1 |
| 7 | Carvedilol or propranolol in portal hypertension? A randomized comparison显示文摘 | Lise Hobolth S?ren M?ller Henning Gr?nb?k Klaus Roelsgaard Flemming Bendtsen Erik Feldager Hansen | 2012 | Scandinavian Journal of Gastroenterology2012，，4： | 1 |
| 8 | Energy Consumption and GDP in Turkey:Is There a Co -integration Relationship 显示文摘 | Lise W Van Montfort K | 2007 | Energy E- conomics2007，29，6： | 1 |
| 9 | Energy consumption and GDP in Turkey: Is there a cointegration relationship 显示文摘 | LISE W VAN MONTFORT K | 2007 | Energy Economics2007，29，6： | 1 |
| 10 | Energy consumption and GDP in Turkey: is there a co-integration relationship? 显示文摘 | LISE W VAN MONTFORT K | 2007 | Energy Economics2007，29，6： | 1 |
| 11 | A simple pentose assay for biomass conversion studies显示文摘 | Lise D Emest K C Y | 1986 | Appl Microbiol Biotechnol1986，24，： | 1 |
| 12 | Energy consumption and GDP in Turkey: Is there a co‐integration relationship? 显示文摘 | Lise W Van Montfort K | 2007 | Energy Economics2007，29，6： | 1 |
| 13 | Bromohydration and bromination of the pendant vinylbenzene groups of commercial poly ( divinylbenzene-co-ethylvinylbenzene) resins with subsequent modifications of the (1,2-dibromoethyl) benzene groups: thiol-containing styrenic resins 显示文摘 | Lise Hubbard K Finch James A Darling Graham D | 1999 | Reactive & Functional Polymers1999，39，： | 1 |
| 14 | Arteriovenous malfor-mations in mice lacking activin receptor-like kinase-1显示文摘 | Lisa D Urness BA Lise K | 2000 | Nat Genet2000，26，11： | 1 |
| 15 | Fruit quality and physiological responses of litchi cultivar McLean' s Red to 1-methylcyclopropene pre-treatment and controlled atmosphere storage conditions显示文摘 | DHARINI S LISE K | 2010 | LWT-Food Science and Technology2010，43，6： | 1 |
| 16 | Integrated application of l-methylcyclopropene and modified atmosphere packaging to improve quality retention of litchi cultivars during storage显示文摘 | de REUCK K SIVAKUMAR D LISE K | 2009 | Postharvest Biology and Technology2009，52，1： | 1 |
| 17 | Systematic Review of Randomized Trials on Vasoconstrictor Drugs for Hepatorenal Syndrome显示文摘 | Lise L Gluud K | 2010 | HEPATOLOGY2010，51，： | 1 |
| 18 | Fruit quality and physiological responses of litchi cultivar McLean' s Red to 1-methylcyclopropene pre-treatment and controlled atmosphere storage conditions显示文摘 | DHARINI S LISE K | 2010 | LWT-Food Science and Technology2010，43，6： | 1 |
| 19 | A modulating role for antioxidants in desiccation tolerance显示文摘 | LISE K SIMONA B | 2005 | Integrative Comparative Biology2005，45，： | 1 |
| 20 | Fruit quality and physiological responses of litchi cultivar McLean,s Red to 1-methylcyclopropene pre-treatment and controlled atmosphere storage conditions显示文摘 | Dharini S Lise K | 2010 | LWT-Food Science and Technology2010，43，6： | 1 |
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