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| 1 | Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model显示文摘人的间充质的干细胞(hMSCs ) 装家到肿瘤地点并且禁止肿瘤细胞的生长。很少对内在的分子的机制被知道连接 hMSCs 到肿瘤房间的指向的抑制。在这研究,我们从 hMSCs 用一个动物移植模型,一个合作文化系统和调节媒介在二根人的 hepatoma 房间线(H7402 和 HepG2 ) 上调查了 hMSCs 的效果。当 SCID 老鼠与 H7402 细胞和 Z3 hMSCs 的一个相等的数字被注射时,动物移植研究证明肿瘤形成的潜伏的时间被延长并且肿瘤尺寸更小。当 co 有教养时与 Z3 房间, H7402 细胞增殖减少了,增加的 apoptosis,和 Bcl-2 的表示, c-Myc,原子抗原(PCNA ) 和 survivin 低是的增殖的房间调整了。在有调节媒介的处理源于 Z3 hMSC 文化以后, H4702 房间出现了减少的形成殖民地的能力和减少的增长。Immunoblot 分析证明 beta-catenin, Bcl-2, c-Myc, PCNA 和 survivin 表示是在 H7402 和 HepG2 房间调整的 down。总起来说,我们的调查结果证明 hMSCs 禁止 H7402 和 HepG2 人的肝癌症房间线的恶意的显型,它包括增长,形成殖民地的能力和 oncogene 表示试管内和体内。而且,我们的研究提供表明小径的 Wnt 可以在调停 hMSC 的指向和肿瘤房间抑制有一个角色的证据。 | Ling Qiao Zhili Xu Tiejun Zhao Zhigang Zhao Mingxia Shi Robert C Zhao Lihong Ye Xiaodong Zhang | 2008 | Cell Research2008，18，4： | 68 |
| 2 | Effect of dietary supplementation with protease on growth performance,nutrient digestibility, intestinal morphology, digestive enzymes and gene expression of weaned piglets显示文摘This study was conducted to investigate the effect of dietary protease supplementation on the growth performance, nutrient digestibility, intestinal morphology, digestive enzymes and gene expression in weaned piglets. A total of 300 weaned piglets(21 days of age Duroc x Large White x Landrace; initial BW = 6.27 ± 0.45 kg) were randomly divided into 5 groups. The 5 diets were: 1) positive control diet(PC), 2) negative control diet(NC), and 3) protease supplementations, which were 100, 200, and 300 mg per kg NC diet. Results indicated that final BW, ADG, ADFI, crude protein digestibility, enzyme activities of stomach pepsin, pancreatic amylase and trypsin, plasma total protein, and intestinal villus height were higher for the PC diet and the supplementations of 200 and 300 mg protease per kg NC diet than for the NC diet(P < 0.05). Supplementations of 200 and 300 mg protease per kg NC diet significantly increased the ratio of villus height to crypt depth(VH:CD) of duodenum, jejunum and ileum compared with NC diet(P < 0.05). Feed to gain ratio, diarrhea index, blood urea nitrogen, and diamine oxidase were lower for the PC diet and supplementations of 200 and 300 mg protease per kg NC diet than for the NC diet(P < 0.05). Piglets fed the PC diet had a higher peptide transporter 1(PepTl) mRNA abundance in duodenum than piglets fed the NC diet(P < 0.05), and supplementations of 100, 200 and 300 mg protease per kg NC diet increased the PepTl mRNA abundance in duodenum(P < 0.05) comparing with the NC diet. Piglets fed the PC diet had a higher b0,+AT mRNA abundance in jejunum than piglets fed the NC diet(P < 0.05), and supplementations of 200 and 300 mg protease per kg NC diet increased the b0,+AT mRNA abundance in jejunum and ileum comparing with the NC diet(P < 0.05). In summary, dietary protease supplementation increases growth performance in weaned piglets, which may contribute to the improvement of intestinal development, protein digestibility, nutrient transport efficiency, and health status of piglets when fed low digestible protein sources. | Jianjun Zuo Baoming Ling Lina Long Tiejun Li Ludovic Lahaye Chengbo Yang Dingyuan Feng | 2015 | Animal Nutrition2015，，4： | 18 |
| 3 | Numerical Simulation of Typhoon Muifa(2011) Using a Coupled Ocean-Atmosphere-Wave-Sediment Transport(COAWST) Modeling System显示文摘The newly developed Coupled Ocean-Atmosphere-Wave-Sediment Transport(COAWST) Modeling System is applied to investigate typhoon-ocean interactions in this study. The COAWST modeling system represents the state-of-the-art numerical simulation technique comprising several coupled models to study coastal and environmental processes. The modeling system is applied to simulate Typhoon Muifa(2011), which strengthened from a tropical storm to a super typhoon in the Northwestern Pacific, to explore the heat fluxes exchanged among the processes simulated using the atmosphere model WRF, ocean model ROMS and wave model SWAN. These three models adopted the same horizontal grid. Three numerical experiments with different coupling configurations are performed in order to investigate the impact of typhoon-ocean interaction on the intensity and ocean response to typhoon. The simulated typhoon tracks and intensities agree with observations. Comparisons of the simulated variables with available atmospheric and oceanic observations show the good performance of using the coupled modeling system for simulating the ocean and atmosphere processes during a typhoon event. The fully coupled simulation that includes a ocean model identifies a decreased SST as a result of the typhoon-forced entrainment. Typhoon intensity and wind speed are reduced due to the decrease of the sea surface temperature when using a coupled ocean model. The experiments with ocean coupled to atmosphere also results in decreased sea surface heat flux and air temperature. The heat flux decreases by about 29% compared to the WRF only case. The reduction of the energy induced by SST decreases, resulting in weakening of the typhoon. Coupling of the waves to the atmosphere and ocean model induces a slight increase of SST in the typhoon center area with the ocean-atmosphere interaction increased as a result of wave feedback to atmosphere. | LIU Na LING Tiejun WANG Hui ZHANG Yunfei GAO Zhiyi WANG Yi | 2015 | Journal of Ocean University of China2015，14，2： | 10 |
| 4 | The influence of ENSO on sea surface temperature variations in the China seas显示文摘Positive SST anomalies usually appear in remote ocean such as the China seas during an ENSO event.By analyzing the monthly data of HadISST from 1950 to 2007,it shows that the interannual component of SST anomalies peak approximately 10 months after SST anomalies peak in the eastern equatorial Pacific.As the ENSO event progresses,the positive SST anomalies spread throughout the China seas and eastward along the Kuroshio extension.Atmospheric reanalysis data demonstrate that changes in the net surface heat flux entering into the China seas are responsible for the SST variability.During El Ni o,the western north Pacific anticyclone is generated,with anomalous southwester lies prevailing along the East Asian coast.This anticyclone reduces the mean surface wind speed which decreases the surface heat flux and then increases the SST.The delays between the developing of this anticyclone and the south Indian Ocean anticyclone with approximately 3–6 months cause the 2–3 months lag of the surface heat flux between the China seas and the Indian Ocean.The northwestern Pacific anticyclone is the key process bridging the warming in the eastern equatorial Pacific and that in the China seas. | LIU Na WANG Hui LING Tiejun FENG Licheng | 2013 | Acta Oceanologica Sinica2013，32，9： | 4 |
| 5 | A 31-year Global Diurnal Sea Surface Temperature Dataset Created by an Ocean Mixed-Layer Model显示文摘A dataset of hourly sea surface temperature(SST) from the period 1 January 1982 to 31 December 2012, and covering the global ocean at a resolution of 0.3°× 0.3°, was created using a validated ocean mixed-layer model(MLSST). The model inputs were heat flux and surface wind speed obtained from the Coupled Forecast System Reanalysis dataset. Comparisons with in-situ data from the Tropical Atmosphere Ocean array and the National Data Buoy Center showed that the MLSST fitted very well with observations, with a mean bias of 0.07℃, and a root-mean-square error(RMSE) and correlation coefficient of 0.37℃ and 0.98, respectively. Also, the MLSST fields successfully reproduced the diurnal cycle of SST in the in-situ data, with a mean bias of -0.005℃ and RMSE of 0.26℃. The 31-year climatology revealed that the diurnal range was small across most regions, with higher values in the eastern and western equatorial Pacific, northern Indian Ocean, western Central America, northwestern Australia, and several coastal regions. Significant seasonal variation of diurnal SST existed in all basins. In the Atlantic and Pacific basins, this seasonal pattern was oriented north–south, following the variation in solar insolation, whereas in the Indian basin it was dominated by monsoonal variability. At the interannual scale, the results highlighted the relationship between diurnal and interannual variations of SST, and revealed that the diurnal warming in the central equatorial Pacific could be a potential climatic indicator for ENSO prediction. | Xiang LI Tiejun LING Yunfei ZHANG Qian ZHOU | 2018 | Advances in Atmospheric Sciences2018，35，12： | 2 |
| 6 | DKK-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling 显示文摘 | Qiao Ling Xu Zhili Zhao Tiejun | 2008 | Cancer Lett2008，269，1： | 1 |
| 7 | Adenocarcinoma transformed into squamous cell carcinoma in non-small cell lung cancer显示文摘Non-small cell lung cancer(NSCLC)is the most common form of lung cancer which remains the deadliest malignancy worldwide(Siegel et al.,2019).In general,NSCLC can be divided into several subtypes,including adenocarcinoma(ADC),squamous cell carcinoma(SCC),adeno-squamous cell carcinoma(AD-SCC)and large cell carcinoma(LCC). | Yueqiang Jiang Jun Zhang Jin Feng Yaping Lu Yuan Fan Ling Cheng Xin Liao Liya Hu Shiying Yu Tiejun Yin | 2021 | Journal of Genetics and Genomics2021，48，7： | 1 |
| 8 | Cerebrosides from the Roots of Serratula chinensis 显示文摘 | Tiejun Ling Tao Xia Xiaochun Wan | 2006 | Molecules2006，11，9： | 1 |
| 9 | Cerebrpsides from the Roots of Serratula chinensis显示文摘 | Tiejun Ling Tao Xia Xiaochun Wan | 2006 | Molecules2006，11，9： | 1 |
| 10 | Phytoecdysteroids and other constituents from the roots of Klaseopsis chinensis 显示文摘 | Tiejun Ling Zhengzhu Zhang Tao Xia | 2009 | Biochem- ical Systematics and Ecology2009，37，1： | 1 |
| 11 | Phytoecdyste- roids and other constituents from the roots of Klaseopsis chinensis显示文摘 | Ling TieJun Zhang ZhengZhu Xia Tao | 2009 | Biochem Syst Ecol2009，37，1： | 1 |
| 12 | Phytoecdysteroids andother constituents from the roots of Klaseopsis chinensis显示文摘 | Tiejun Ling Zhengzhu Zhang Tao Xia | 2009 | Biochem-ical Systematics and Ecology2009，37，1： | 1 |
| 13 | Corrigendum to 'Dark tea: A popular beverage with possible medicinal application' [Chinese Herbal Medicines 15 (2023) 33-36]显示文摘When this paper was first published,the authors'name Miamoiao Lea was incomplete.The corrected author name has been shown above.The authors would like to apologise for any inconvenience caused. | Hongjing Pan Miaomiao Le Chunnian He Chung S.Yang Tiejun Ling | 2023 | Chinese Herbal Medicines2023，15，4： | 0 |
| 14 | Soil and fine root-associated microbial communities are niche dependent and influenced by copper fungicide treatment during tea plant cultivation显示文摘Dear Editor,Fungicide treatment has a profound effect on controlling plant pathogens in modern agriculture,however,it also carries the risk of undesirable outcomes.For decades,scientists have been concerned about the harmful impacts of heavy metals like copper(Cu)on crop performance and soil microorganisms.Use of various copper fungicides,like Bordeaux mixture,have been a component of conventional agricultural practices to control fungal and bacterial pathogens,especially in vineyards,tea gardens,or fruit tree orchards[9,10].This treatment increases the accumulation of high levels of Cu in surface soils,and despite the critical role of Cu as an essential trace element in wide biological and metabolic processes,it becomes toxic to plants when applied at high levels[4].The regular application of copper fungicides has also been linked to affecting microbial communities at the levels of diversity[8],population structure[2],abundance,and growth[1,3].Understanding the undesired effects of fungicides on microorganisms’beneficial activities is therefore important for evaluating the hazards associated with the fungicide used in agriculture.Yet,the effects of copper fungicide on full microbial communities remains relatively understudied,especially in tea plants.Thus,we herein explored the inf luence of Bordeaux mixture under different management regimes(raking or without raking leaf litter)on microbial communities of root,bulk soil,and rhizosphere compartments of tea plants planted in a ten-year-old tea garden.We provided insights into the ecological consequences of tea management practices that might help to identify specific fungicide treatment regimens,environmental characteristics,and microbial community members to minimize the negative environmental outcomes and optimize the positive anti-pathogen aspects of fungicide treatment. | Ali Inayat Mallano Jie Yu Tabys Dina Fangdong Li Tiejun Ling Naveed Ahmad Jeffrey Bennetzen Wei Tong | 2023 | Horticulture Research2023，10，3： | 0 |
| 15 | Dark tea: A popular beverage with possible medicinal application显示文摘Tea is a famous beverage that is produced from leaves of Camellia sinensis.Amongst the six major tea categories in China,dark tea is the only one that involves microbial fermentation in the manufacturing process,which contributes unique flavors and functions for the tea.In the recent decade,the reports about the biofunctions of dark teas have increased rapidly.Therefore it may be the proper time to consider dark tea as one potential homology of medicine and food.In this viewpoint,our current understanding of the chemical constituents,biological activities and possible health beneficial effects of dark teas were introduced.Some future directions and challenges to the development perspectives of dark teas were also discussed. | Hongjing Pan Miamoiao Le Chunnian He Chung S.Yang Tiejun Ling | 2023 | Chinese Herbal Medicines2023，15，1： | 0 |
| 16 | Boosting the partial least square algorithm for regression modelling显示文摘增加的算法是过去常改进回归分析的一般性能的一般方法的一个类。主要想法是在火车集合上维持分布。以便直接使用给定的分发,一请修改了算法被建议并且用作基础学习者处理非线性多变量回归问题。Experimentson 汽油辛烷数字预言表明那增加请修改了算法在 PLS 算法上有更好一般的性能。 | Ling YU Tiejun WU | 2006 | 控制理论与应用(英文版)2006，4，3： | 0 |
| 17 | microR-1294-5p inhibits glycolytic metabolism of non-small cell lung cancer cells via targeting TMPRSS11B显示文摘Non-smallcell lung cancer(NSCLC)cells intake and consume glucose at high efficiency by aerobic glycolysis to maintain robust cell growth and resist cell death.MicroRNAs(miRNAs)have been known to play pivotal roles in NSCLC development partly through mediating glycolysis.However,only a few miRNAs have been experimentally confirmed as critical regulators of glycolysis in NSCLC.TCGA datasets were analyzed to screen for differentially expressed miRNAs between NSCLC and normal tissues.The function of miR-1294-5p was determined in NSCLC cells by cell proliferation,glucose uptake,lactate release,and Extracellular Acidification Rate(ECAR)assays.The target of miR-1294-5p was predicted by TargetScan and miRDB,which was further validated by flow cytometry analysis,RT-qPCR,western blotting,a dual-luciferase reporter assay,and RNA immunoprecipitation(RIP)assay.In the present study,it was found that miR-1294-5p was a significantly downregulated miRNA in lung adenocarcinoma(LUAD)and lung squamous cell carcinoma(LUSC).The overexpression of miR-1294-5p inhibited glycolysis,lactate export,ECAR,and cell proliferation in NSCLC cells.Analysis with bioinformatic tools,Western Blotting,RT-qPCR,flow cytometry analysis,dual-luciferase reporter assay,and RIP assay showed that miR-1294-5p directly bound to complementary sites in the 3’-Untranslated Region(UTR)of TMPRSS11B resulted in downregulation of TMPRSS11B expression.In addition,transfection of recombinant TMPRSS11B rescued the functions of miR-1294-5p on glycolysis and proliferation of NSCLC cells.The findings provided novel insights for understanding the regulation of glycolytic metabolism in NSCLC. | JI ZHU XIYING BO GENGXI JIANG SHIHUA YAO TIEJUN ZHAO LING CHEN | 2021 | BIOCELL2021，45，3： | 0 |
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