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| 1 | Human herpesvirus 6B infection in mesial temporal lobe epilepsy:a meta-analysis显示文摘Background Whether human herpesvirus 6B(HHV-6B)can affect mesial temporal lobe epilepsy(MTLE)remains controversial.The present meta-analysis was aimed to evaluate whether HHV-6B is significantly associated with MTLE.Methods Six studies were included in this meta-analysis,comprising 183 MTLE patients and 75 controls.In these studies,HHV-6B infection in astrocytes and brain samples of MTLE patients and controls was investigated by polymerase chain reaction and immunofluorescence.Results The frequency of HHV-6B infection detection is significantly higher in the MTLE group than in the control group(OR=9.42,95%CI:3.66–24.25),(P<0.00001).Although febrile convulsion is strongly associated with MTLE,the formation of febrile convulsion leading to MTLE is not associated with HHV-6B infection(OR=2.68,95%CI:0.93–7.73),(P=0.07).Moreover,the HHV-6B-specific antigen is co-localized to cells positive for GFAP that morphologically resemble astrocytes.HHV-6B mainly infects astrocytes,oligodendrocytes and microglia,and could damage the vascular endothelial cells of the central nervous system.Conclusions There is an association between HHV-6B infection and MTLE.Future large-scale,multi-center,controlled,prospective studies are required to confirm these findings.In addition,the exact mechanism underlying the effects of HHV-6B infection on MTLE needs to be further investigated. | Jingyi Tong Qin Zou Sheng Wang Jiaqi Liu Rong Chen Yongmin Chen Wenjie Zhao Lin Ma Qifu Li | 2022 | Acta Epileptologica2022，5，2： | 0 |
| 2 | Rapid Microwave Assisted Synthesis and Antiproliferative Evaluation of Novel Steroidal Thiazole Derivatives显示文摘Three series of novel steroidal thiazole derivatives were synthesized by microwave assisted one-potreaction from pregnenolone, testosterone and estrone, respectively. Their structures were characterized by IR, NMRand HRMS, and the antiproliferative activities of all the synthesized compounds against human cervical carcinoma(HeLa), human liver carcinoma(HepG2), human lung carcinoma(A549), nasopharyngeal carcinoma(CNE2) andnormal kidney epithelial cells(HEK293T) were screened. Among the compounds, 1-estron-17'-ylidene-2-[4'-(p-bromophenyl)-2'-thiazol]hydrazone(12) displayed distinct antiproliferative activity against all the tested cancercell lines and was almost inactive to normal kidney epithelial cells. | HUANG Yanmin ZHAO Dandan LIU Chang GAN Chunfang ZHAN Junyan LIN Qifu SHI Haixin CUI Jianguo | 2017 | Chemical Research in Chinese Universities2017，33，2： | 0 |
| 3 | Effects of Blending Long-Chain Alcohols with Jet Fuel on the Macroscopic Spray Characteristics显示文摘Long-chain alcohols were considered to be promising alternative fuels and fuel additives. This study was aimed at figuring out the influences of blending long-chain alcohols with jet fuel on the macroscopic spray characteristic. n-Butanol and n-pentanol were chosen as tested alternative fuels. A common-rail injection system was used to create high-pressure injection conditions. The Schlieren imaging system was used to capture spray processes. Results showed that with the addition of long-chain alcohols, the spray tip penetration and the peak spray tip velocity increased, whereas the spray cone angle and the spray area decreased. Comparisons between those macroscopic spray characteristics of AKB blends and AKP blends were also conducted. Compared to AKB blends, AKP blends showed similar spray tip penetration, larger peak tip velocity, smaller spray cone angle, and smaller spray area. | Li Fengyu Liu Yanju Huang Qifu Fu Wei Shi Weidong Lin Qizhao | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，4： | 0 |
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