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| 1 | Matrix metalloproteinase-9:A deleterious link between hepatic ischemia-reperfusion and colorectal cancer显示文摘Despite the advent of improved surgical techniques and the development of cytotoxic chemotherapeutic agents useful for the treatment of colorectal cancer,the primary clinical challenge remains that of preventing and combating metastatic spread.Surgical resection is the best treatment for colorectal metastases isolated to the liver.However,in rodent models,the hepatic ischemia-reperfusion(I/R) applied during the surgery accelerates the outgrowth of implanted tumors.Among the adverse effects of I/R on cellular function,several studies have demonstrated an over expression of the matrix metalloproteinase-9(MMP-9) in the ischemic liver.Since several studies showed high local levels of expression and activity of this proteolytic enzyme in the primary colorectal adenocarcinoma,the role of MMP-9 might be considered as a potential common mediator,favoring both growth of local tumor and the dissemination of colorectal carcinoma metastases. | Sébastien Lenglet Franois Mach Fabrizio Montecucco | 2012 | World Journal of Gastroenterology2012，18，48： | 6 |
| 2 | Statin Treatment Is Associated with Reduction in Serum Levels of Receptor Activator of NF- κ B Ligand and Neutrophil Activation in Patients with Severe Carotid Stenosis显示文摘 | Sébastien Lenglet Alessandra Quercioli Mathias Fabre Katia Galan Graziano Pelli Alessio Nencioni Inga Bauer Aldo Pende Magaly Python Maria Bertolotto Giovanni Spinella Bianca Pane Domenico Palombo Franco Dallegri Fran?ois Mach Nicolas Vuilleumier Fabrizio | 2014 | Mediators of Inflammation2014，，： | 2 |
| 3 | CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion显示文摘 | Montecucco F Lenglet S Braunersreuther V | 2009 | J Mol Cell Cardiol2009，46，5： | 1 |
| 4 | Single administration of the CXC chemokine-binding protein Evasin-3 during ischemia prevents myocardial reperfusion injury in mice显示文摘 | Montecucco F Lenglet S Braunersreuther V | 2010 | Arterioscler Thromb Vasc Biol2010，30，7： | 1 |
| 5 | CC che- mokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in miee显示文摘 | Montecucco F Braunersreuther V Lenglet S | 2012 | Ear Heart J2012，33，15： | 1 |
| 6 | Role of Matrix Metalloproteinase-8 in Atherosclerosis显示文摘 | Sébastien Lenglet Fran?ois Mach Fabrizio Montecucco Jane Stubbe | 2013 | Mediators of Inflammation2013，，： | 1 |
| 7 | Recombinant tissue plasminogen activator enhances microglial cell recruitment after stroke in mice显示文摘 | Lenglet S Monteeucco F Denes A | 2014 | J Cereb Blood Flow Metab2014，34，5： | 1 |
| 8 | CB2 cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion显示文摘 | MONTECUCCO F LENGLET S BRAUNERSREUTHER V | 2009 | J Mol Cell Cardiol2009，46，5： | 1 |
| 9 | Use of nicotinamide to treat hyperphosphatemia in dialysis patients显示文摘 | Lenglet A Liabeuf S Guffroy P | 2013 | Drugs R D2013，13，3： | 1 |
| 10 | Single ad- ministration of the CXC chemokine-binding protein Evasin-3 during ischemia prevents myocardial reper-fusion injury in mice显示文摘 | Montecucco F Lenglet S Braunersreuther V | 2010 | Arterioscler Thromb Vasc Biol2010，30，： | 1 |
| 11 | Alpha-fetoprotein:A controversial prognostic biomarker for small hepatocellular carcinoma显示文摘The assessment of the prognosis in patients with early hepatocellular carcinoma represents a hot-topic issue that requires further improvements and clarifications. The life expectancy of the patients has been shown to depend on several clinical and histological parameters (such as patient's general conditions,macroscopic tumor morphology and histopathology).Recently,the prognostic role of some biomarkers[i.e.,alpha-fetoprotein(AFP)] has been also investigated with controversial findings mainly on the assessment of patient survival.The study by Giannini et al failed to show a prognostic value of AFP on survival of patients with well-compensated cirrhosis and small hepatocellular carcinoma.Since the study presents some limitations,a larger clinical trial is needed to clarify the potential prognostic role of serum AFP levels in these patients. | Mohamed Asrih Sébastien Lenglet Franois Mach Fabrizio Montecucco | 2013 | World Journal of Gastroenterology2013，19，3： | 1 |
| 12 | Plasma beta-2 microglob- ulin is associated with cardiovascular disease in uremic patients显示文摘 | Liabeuf S Lenglet A Desjardins L | 2012 | Kidney Int2012，82，： | 1 |
| 13 | Treatment with Evasin 3 abrogates neutrophil-mediated inflammation in mouse acute pancreati- tis显示文摘 | Monteeucco F Maeh F Lenglet S | 2014 | Eur J Clin Invest2014，44，10： | 1 |
| 14 | Methylene blue:Potential use of an antique molecule in vasoplegic syndrome during cardiac surgery显示文摘 | Lenglet S Mach F Montecucco F | 2011 | Expert Rev Cardiovasc Ther2011，9，12： | 1 |
| 15 | Treatment with Evasin-3 abrogates neutrophil-mediated inflammation in mouse acute pancre- atitis显示文摘 | Montecucco F Mach F Lenglet S | 2014 | EurJ Clin Invest2014，44，10： | 1 |
| 16 | Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La R6union 显示文摘 | G6rardin P Barau G Michault A Binmer M Randrianaivo H Choker G Lenglet Y Touret Y Bouveret A Grivard P Le Roux K Blanc S Schuffenecker I Couderc T Arenzana-Seisdedos F Lecuit M Robillard PY | 2008 | PLoS Med2008，5，3： | 1 |
| 17 | Hint2 is expressed in tile mito- chondria of H295R cells and is inwlved in stenidgenesis显示文摘 | Lenglet S Antigny F Vetterli L | 2008 | Endo-crinol2008，149，11： | 1 |
| 18 | Plasma beta-2microglobulin is associated with cardiovascular disease in uremic patients显示文摘 | Liabeuf S Lenglet A Desjardins L | 2012 | Kidney Int2012，82，12： | 1 |
| 19 | Molecular imaging of matrixmetalloproteinases in atherosclerotic plaques 显示文摘 | Lenglet S Thomas A Chaurand P | 2012 | Thromb Haemost2012，107，3： | 1 |
| 20 | Analysis of the expression of nine secreted matrix metalloproteinases and their endogenous inhibitors in the brain of mice subjected to ischaemic stroke显示文摘 | Lenglet S Montecucco F Mach F | 2014 | Thromb Haemost2014，112，2： | 1 |
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