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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial显示文摘 | Femke Mol Norah M van Mello Annika Strandell Karin Strandell Davor Jurkovic Jackie Ross Kurt T Barnhart Tamer M Yalcinkaya Harold R Verhoeve Giuseppe C M Graziosi Carolien A M Koks Ingmar Klinte Lars Hogstr?m Ineke C A H Janssen Harry Kragt Annemieke Hoek | 2014 | The Lancet2014，，： | 2 |
| 3 | Stoichiometric modeling of clostridium acetotutylicum fermentations with non-linear constraints显示文摘 | Desai R P Lars K Nielsen Papoutsakis E T | | 0，，01： | 1 |
| 4 | Exposure to polybrominated diphenyl ethers and tetrabromobisphenol A among computer technicians 显示文摘 | Kristina J Kaj T Lars R | 2002 | Chemosphere2002，46，： | 1 |
| 5 | Eearly intrathecal production of interleukin-6 predicts the size of brain lesion in stroke 显示文摘 | Elisabeth T Lars R Christian B | 1995 | Stroke1995，26，： | 1 |
| 6 | Measuring the effectiveness of of-fensive match-play in professional soccer 显示文摘 | ALBIN T LARS T R | 2010 | Eur J Sport Sci2010，10，4： | 1 |
| 7 | Age-dependent wound in duction of a myrosinase associated protein from oilseed rape (Brassica napus) 显示文摘 | Erik A Jan T Lars R | 1999 | Plant Molecular Biology1999，，41： | 1 |
| 8 | The N20 product ratio of nitrification and its dependence on long-term changes in soil pH显示文摘 | Pal T M Peter D Lars R B | 2007 | Soil Biology and Biochemistry2007，39，： | 1 |
| 9 | 显示文摘 | Fontaine M L Larring Y Haugsrud R Norby T Wiik K Bre-desen R | 2009 | J Power Sources2009，188，1： | 1 |
| 10 | Does glioblastoma cyst fluid promote sciatic nerve regeneration?显示文摘Glioblastoma cyst fluid contains growth factors and extracellular matrix proteins which are known as neurotrophic and neurite-promoting agents. Therefore, we hypothesized that glioblastoma cyst fluid can promote the regeneration of injured peripheral nerves. To validate this hypothesis, we transected rat sciatic nerve, performed epineural anastomosis, and wrapped the injured sciatic nerve with glioblastoma cyst fluid- or saline-soaked gelatin sponges. Neurological function and histomorphological examinations showed that compared with the rats receiving local saline treatment, those receiving local glioblastoma cyst fluid treatment had better sciatic nerve function, fewer scars, greater axon area, counts and diameter as well as fiber diameter. These findings suggest that glioblastoma cyst fluid can promote the regeneration of injured sciatic nerve and has the potential for future clinical application in patients with peripheral nerve injury. | Rafet ?zay Abit Akta? Mevlüt ?zgür Ta?kap?l?o?lu Bora Gürer Bülent Erdo?an Yusuf ?ükrü ?a?lar | 2015 | Neural Regeneration Research2015，10，10： | 0 |
| 11 | Gastrointestinal function testing model using a new laryngopharyngeal pH probe(Restech)in patients after Ivor-Lewis esophagectomy显示文摘BACKGROUND There is no established correlation between 24-h esophageal pH-metry(Eso-pH)and the new laryngopharyngeal pH-monitoring system(Restech)as only small case series exist.Eso-pH was not designed to detect laryngopharyngeal reflux(LPR)and Restech may detect LPR better.We have previously published a dataset using the two techniques in a large patient collective with gastroesophageal reflux disease.Anatomically,patients after esophagectomy were reported to represent an ideal human reflux model as no reflux barrier exists.AIM To use a human reflux model to examine our previously published correlation in these patients.METHODS Patients after Ivor Lewis esophagectomy underwent our routine follow-up program with surveillance endoscopies,computed tomography scans and further exams following surgery.Only patients with a complete check-up program and reflux symptoms were offered inclusion into this prospective study and evaluated using Restech and simultaneous Eso-pH.Subsequently,the relationship between the two techniques was evaluated RESULTS A total of 43 patients from May 2016-November 2018 were included.All patients presented with mainly typical reflux symptoms such as heartburn(74%),regurgitation(84%),chest pain(58%),and dysphagia(47%).Extraesophageal symptoms such as cough,hoarseness,asthma symptoms,and globus sensation were also present.Esophageal 24-hour pH-metry was abnormal in 88%of patients with a mean DeMeester Score of 229.45[range 26.4-319.5].Restech evaluation was abnormal in 61%of cases in this highly selective patient cohort.All patients with abnormal supine LPR were also abnormal for supine esophageal reflux measured by conventional Eso-pH.CONCLUSION Patients following esophagectomy and reconstruction with gastric interposition can ideally serve as a human reflux model.Interestingly,laryngopharyngeal reflux phases occur mainly in the upright position.In this human volume-reflux model,results of simultaneous esophageal and laryngopharyngeal(Restech)pHmetry showed 100%correlation as being explicable by one of our reflux scenarios. | Benjamin Babic Dolores T Müller Florian Gebauer Lars Mortimer Schiffmann Rabi R Datta WolfgangSchröder Christiane J Bruns Jessica M Leers Hans F Fuchs | 2021 | World Journal of Gastrointestinal Oncology2021，13，6： | 0 |
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