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| 1 | Embryo-mediated genome editing for accelerated genetic improvement of livestock显示文摘Selecting beneficial DNA variants is the main goal of animal breeding.However,this process is inherently inefficient because each animal only carries a fraction of all desirable variants.Genome editing technology with its ability to directly introduce beneficial sequence variants offers new opportunities to modernize animal breeding by overcoming this biological limitation and accelerating genetic gains.To realize rapid genetic gain,precise edits need to be introduced into genomicallyselected embryos,which minimizes the genetic lag.However,embryo-mediated precision editing by homology-directed repair(HDR)mechanisms is currently an inefficient process that often produces mosaic embryos and greatly limits the numbers of available edited embryos.This review provides a summary of genome editing in bovine embryos and proposes an embryo-mediated accelerated breeding scheme that overcomes the present efficiency limitations of HDR editing in bovine embryos.It integrates embryo-based genomic selection with precise multi-editing and uses embryonic cloning with elite edited blastomeres or embryonic pluripotent stem cells to resolve mosaicism,enable multiplex editing and multiply rare elite genotypes.Such a breeding strategy would enable a more targeted,accelerated approach for livestock improvement that allows stacking of beneficial variants,even including novel traits from outside the breeding population,in the most recent elite genetic background,essentially within a single generation. | Zachariah MCLEAN Björn OBACK Götz LAIBLE | 2020 | Frontiers of Agricultural Science and Engineering2020，7，2： | 2 |
| 2 | SET domain proteins modulate chromatin domains in eu-and heterochromatin显示文摘 | Jenuwein T Laible G Dorn R etal | 1998 | Cell Mol Life Sci1998，54，1： | 1 |
| 3 | The differential relations of parent and peer attachment to adolescent adjustment显示文摘 | LAIBLE DJ CARLO G RAFFAELLI M | 2000 | J Youth Adoles2000，29，1： | 1 |
| 4 | Coordination between donor cell type and cell cycle stage improves nuclear cloning efficiency in cattle显示文摘 | DN Wells G Laible FC Tucker | 2003 | Theriogenology2003，59，： | 1 |
| 5 | Coordination Between Donor Cell Type and Cell Cycle Stage Improves Nuclear Cloning Ffficiency in Cattle 显示文摘 | WELLS D N LAIBLE G TUCKER F C | 2003 | Theriogenology2003，59，： | 1 |
| 6 | Coordination between donor cell type and cell cycle stage improves nuclear cloning efficiency in cattle 显示文摘 | Wells DN Laible G Tucker FC | 2003 | Theriogenology2003，59，1： | 1 |
| 7 | Protamine sulfate protects exogenous DNA against nuclease degradation but is unable to improve the efficiency of bovine spermmediated transgenesis 显示文摘 | ALDERSON J WILSON B LAIBLE G | 2006 | Anim Reprod Sci2006，91，12： | 1 |
| 8 | Coordination between donor cell type and cell cycle stage improves nuclear cloning efficiency in cattle显示文摘 | Wells D N Laible G Tucker F C | 2003 | Theriogenology2003，，59： | 1 |
| 9 | Compositional analysis of dairy products derived from clones and cloned transgenie cattle 显示文摘 | Laible G Brophy B Knighton D | 2007 | Theriogenology2007，67，1： | 1 |
| 10 | SET domain proteins modulate ehromatin domains in euand heterochromatin显示文摘 | JENUWEIN T LAIBLE G DORN R | 1998 | Cell Mol Life Sci1998，54，： | 1 |
| 11 | Bactericidal activity of human lysozyme,Muramidase-inactive lysozyme,and cationic polypeptides against Streptococcus sanguis and Streptococcus faecalis:Inhibition by chitin oligosaccharides显示文摘 | LAIBLE N J GERMAINE G R | 1985 | Infect Immun1985，48，： | 1 |
| 12 | Compositional analysis of dairy products derived from clones and cloned transgenic cattle显示文摘 | Laible G Brophy B Knighton D Wells DN | 2007 | Theriogenology2007，67，1： | 1 |
| 13 | Enhancing livestock through genetic engineering-recent advances and future prospects 显示文摘 | LAIBLE G | 2009 | Comp Immunol Microbiol Infect Dis2009，32，： | 1 |
| 14 | Coordination between donor cell type and cell cycle stage improves nuclear cloning efficiency in cattie显示文摘 | Wells D N Laible G Tucker F C | 2003 | Theriogenology2003，59，： | 1 |
| 15 | Compositional analysis of dairy products derived from clones and cloned transgenic cattle 显示文摘 | LAIBLE G BROPHY B KNIGHTON D | | Theriogenology0，67，： | 1 |
| 16 | Compositional analysis of dairy products derived from clones and cloned transgenic cattle显示文摘 | Laible G Brophy B Knigh ton D | 2007 | Theriogenology2007，67，1： | 1 |
| 17 | Bactericidal activity of human lysozyme,muramidase-inactive lysozyme,and cat-ionic polypeptides against Streptococcus sanguis and Streptococcus faecalis:inhibition by chitin oligosaccharides显示文摘 | Laible N J Germaine G R | 1985 | Infect Immun1985，48，3： | 1 |
| 18 | SET domain proteins modulatechro- matin domains in eu- and heterochromatin显示文摘 | Jenuwein T Laible G Dom R | 1998 | Cell Mol Life Sci1998，54，： | 1 |
| 19 | UC Davis transgenic animal research conference VI显示文摘 | Laible G Fahrenkrug SC | 2012 | Transgenic Res2012，21，6： | 1 |
| 20 | Coordination between donor cell type and cell cycle stage improves nuclear cloning efficiency in cattle 显示文摘 | Wells D N Laible G Tucker F C | 2003 | Theriogenology2003，59，： | 1 |
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