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| 1 | 癌症筛查之未来显示文摘1引言癌症已成为美国的第二大致死病因,52%的人死于肺癌、支气管癌、女性乳腺癌、宫颈癌、结直肠癌、口腔及咽喉癌、前列腺癌和皮肤癌(黑色素瘤)。19世纪30年代,包括宫颈癌在内的子宫癌,位居美国女性癌症死亡第一位。50年代,随着巴氏涂片技术(Pap test)的应用,可以在细胞水平检测宫颈的变化,宫颈癌死亡率显著降低,这是第一个癌症筛查检测技术。此后,已有多种影像学检查(例如乳腺癌钼靶X线、内窥镜检查和计算机体层扫描)和实验室检测方法(粪便隐血试验)用于癌症筛检。 | Cheryll C.Thomas Thomas B.Richards Marcus Plescia Faye L.Wong Rachel Ballard Theodore R.Levin Bruce N.Calonge Otis W.Brawley John Iskander 徐海燕(翻译) 陆仁敏(审校) 蔡颖(审校) | 2017 | 上海预防医学2017，29，3： | 2 |
| 2 | 老年癌症患者的免疫治疗显示文摘癌症常见于老年人。初诊为恶性肿瘤的患者的中位年龄为66岁,癌症相关死亡的中位年龄为72岁[1]。老年人是癌症患病率增长最快的人群之一[2]。免疫治疗的发展,尤其是免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)的问世,彻底改变了所有年龄层包括老年人在内的肿瘤患者的常规治疗方案。细胞毒性T淋巴细胞相关抗原4、程序性死亡受体1(programmed death receptor-1,PD-1)及其配体(programmed death-ligand 1,PD-L1)的抑制剂可改善多种肿瘤患者的总生存期(overall survival,OS)[3],且部分患者可获得持续缓解[4]。 | Carolyn J.PRESLEY Fabio GOMES Christin E.BURD Ravindran KANESVARAN Melisa L.WONG 李昕(翻译) 陈军(校对) | 2021 | 中国肺癌杂志2021，24，10： | 2 |
| 3 | NOD2/CARD15 gene polymorphisms and Crohn’s disease in the Chinese population显示文摘 | R. W. L.Leong A.Armuzzi T.Ahmad M. L.Wong P.Tse D. P.Jewell J. J. Y.Sung | 2003 | Alimentary Pharmacology & Therapeutics2003，，12： | 1 |
| 4 | ORIGINAL ARTICLE: Optimal timing for the administration of intranasal dexmedetomidine for premedication in children显示文摘 | V. M.Yuen Theresa W.Hui M. G.Irwin T.‐J.Yao G. L.Wong M. K.Yuen | 2010 | Anaesthesia2010，，9： | 1 |
| 5 | Growth of ZnO Thin Film by Laser MBE: Lasing of Exciton at Room Temperature显示文摘 | Y.Segawa A.Ohtomo M.Kawasaki H.Koinuma Z. K.Tang P.Yu G. K. L.Wong | 2001 | phys. stat. sol. (b)2001，，2： | 1 |
| 6 | The Morning Blood Pressure Surge: Therapeutic Implications显示文摘 | Priyesh V.Patel Justin L.Wong RohitArora | 2008 | The Journal of Clinical Hypertension2008，，2： | 1 |
| 7 | Hepatitis B and alcohol affect survival of hepatocellular carcinoma patients显示文摘AIM: In the USA, Hawaii has the highest incidence of hepatocellular carcinoma (HCC) and a diverse population.It is an ideal place to characterize HCC in the context of ethnicity/risk factors.METHODS: A total of 262 cases of HCC (1992-2003) were retrospectively reviewed for demographics, ethnicity, birthplace, viral hepatitis, alcohol use, diabetes, smoking and risk factors for viral hepatitis such as intravenous drug abuse (IVDA), transfusions, tattoos and vertical transmission. Tumor stage, Child's class, Cancer of the Liver Italian Program (CLIP) score, α-fetoprotein level, treatment and survival were recorded.RESULTS: Gender, age, viral hepatitis, alcohol, IVDA, and diabetes differed significantly in Asians, non-Asians and Pacific Islanders. There were also specific differences within Asian subgroups. Alpha-fetoprotein, smoking, transfusions, stage and resectability did not differ between groups. Asians were more likely to have hepatitis B, while non-Asians were more likely to have hepatitis C. Factors that decreased survival included hepatitis B, alcohol, elevated alpha-fetoprotein, CLIP >2 and increased Child's class. When Asians were combined with Pacific Islanders, median survival (1.52 years vs 3.54 years), 1- and 3-year survival was significantly worse than those for non-Asians. After Cox regression analysis for hepatitis B and alcohol, there was no difference in survival by ethnicity.CONCLUSION: Various ethnicities have different risk factors for HCC. Hepatitis B, alcohol, and α-fetoprotein are more important factors for survival than ethnicity. | Linda L.Wong Whitney M.Limm Naoky Tsai Richard Severino | 2005 | World Journal of Gastroenterology2005，11，23： | 1 |
| 8 | ORIGINAL ARTICLE: Optimal timing for the administration of intranasal dexmedetomidine for premedication in children显示文摘 | V. M.Yuen Theresa W.Hui M. G.Irwin T.‐J.Yao G. L.Wong M. K.Yuen | 2010 | Anaesthesia2010，，9： | 1 |
| 9 | Beginning Teachers' Pedagogical Skills and Knowledge Towards Positive Pedagogic Teacher-Student Relationships显示文摘 | Doris Choy Angela F. L.Wong Sylvia Chong Kam Ming Lim | 2014 | US-China Education Review(B)2014，4，6： | 0 |
| 10 | Prognostic ability of inflammation-based markers in radioembolization for hepatocellular carcinoma显示文摘Aim:Inflammation-based markers,such as the neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR),have recently been used as prognostic indicators in hepatocellular carcinoma(HCC).We aimed to determine whether NLR and PLR may predict response to yttrium-90 transarterial radioembolization(TARE)as primary treatment for HCC.Methods:We performed a retrospective review of a prospectively collected database of HCC cases(1994-2019)and selected patients who received TARE as primary treatment(n=42).Laboratory studies were used to calculate NLR and PLR.Response to TARE was determined using the modified response evaluation criteria in solid tumors(mRECIST).Patients were classified as non-responders(stable or progressive disease)or responders(partial or complete response)to treatment based on mRECIST.Results:Receiver operating characteristic curves identified a pre-treatment NLR cutoff of≥2.83 and a pre-treatment PLR cutoff of≥83 for predicting non-response to treatment.Pre-treatment NLR≥2.83 was the only significant predictor of non-response to TARE in multivariate logistic regression analysis(odds ratio 7.83,P=0.036).On time to progression analysis,both pre-treatment NLR≥2.83 and pre-treatment PLR≥83 were associated with a higher proportion of tumor progression at 6 months post-treatment(43.6%vs.10.0%,P=0.014,log-rank)and(38.6%vs.0%,P=0.010,log-rank),respectively.Conclusion:NLR confers prognostic value and may be superior to PLR in determining response to TARE as primary treatment for HCC.Future studies are necessary to validate these findings in a larger cohort. | Grant Yoneoka Kliment Bozhilov Linda L.Wong | 2020 | Hepatoma Research2020，6，10： | 0 |
| 11 | 摆脱阴影:作为国家战略资源的太阳能显示文摘内部的环境挑战和外部经济的不确定性促使中国重新审视自己的能源安全政策,加大对太阳能光伏产业的扶持力度。中国的规划者要抓住当前时机,制定更加大胆的太阳能产业政簧。分布式太阳能发电可以加强中国电力供应的灵活性,在城乡都可以产生清洁电力,并且能创造出高技术工作机会。 | 黄立安(Julian L.Wong) 陆新超(译) | 2009 | 国外社会科学文摘2009，，11： | 0 |
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