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| 1 | Functions of NKG2D in CD8^(+) T cells: an opportunity for immunotherapy显示文摘Natural killer group 2 member D(NKG2D)is a type II transmembrane receptor.NKG2D is present on NK cells in both mice and humans,whereas it is constitutively expressed on CD8+T cells in humans but only expressed upon T-cell activation in mice.NKG2D is a promiscuous receptor that recognizes stress-induced surface ligands.In NK cells,NKG2D signaling is sufficient to unleash the killing response;in CD8+T cells,this requires concurrent activation of the T-cell receptor(TCR).In this case,the function of NKG2D is to authenticate the recognition of a stressed target and enhance TCR signaling.CD28 has been established as an archetype provider of costimulation during T-cell priming.It has become apparent,however,that signals from other costimulatory receptors,such as NKG2D,are required for optimal T-cell function outside the priming phase.This review will focus on the similarities and differences between NKG2D and CD28;less well-described characteristics of NKG2D,such as the potential role of NKG2D in CD8+T-cell memory formation,cancer immunity and autoimmunity;and the opportunities for targeting NKG2D in immunotherapy. | Kushal Prajapati Cynthia Perez Lourdes Beatriz Plaza Rojas Brianna Burke Jose A Guevara-Patino | 2018 | Cellular & Molecular Immunology2018，15，5： | 7 |
| 2 | Brucellosis and tuberculosis:Clinical overlap and pitfalls显示文摘Objective:To identify characteristic features of tuberculosis in patients with culture proven brucellosis.Methods:A retrospective analysis was performed on patients diagnosed with culture proven brucellosis between January and December 2011,based on review of their medical records.Patients with demonstrable co-infection with tuberculosis were excluded.Clinical features,laboratory parameters and tissue histopathology reports where available were noted.Results:Thirty-two patients with brucellosis were included in the study.Twenty-one(65.63%)patients had chronic fever,thirteen(40.63%)had a productive cough,while significant weight loss,evening rise of temperature and night sweats were reported by eight(25.00%),eleven(34.38%)and five(15.63%)patients respectively.Nine(28.13%)patients had at least three of these symptoms.Lymphadenopathy,hepatomegaly and splenomegaly were noted on examination in seven(21.88%),fifteen(46.88%)and twelve(37.50%)patients respectively.Eight(25.00%)patients had hepatosplenomegaly,of these only two had associated significant lymphadenopathy.Respiratory examination was normal in all patients.Elevated ESR greater than 50 mm/hr was seen in eight(25.00%),it was greater than 100 mm/hr in five(15.63%)patients.Hypergammaglobulinemia was seen in eight(25.00%)cases.Bone marrow biopsy showed non-caseating granulomas in three(9.38%)cases,lymph node biopsy showed granulomas in one case.Overall,three(9.38%)patients had known risk factors for tuberculosis,while six(18.75%)had risk factors for brucellosis.Conclusions:There is a clear overlap between brucellosis and tuberculosis both in terms of clinical presentation and laboratory parameters.It is essential to c-arefully rule out tuberculosis in all cases of suspected or proven brucellosis before initiating antimicrobial therapy,in order to forestall development of drug-resistant tuberculosis. | Sowjanya Dasari Kushal Naha Mukhyaprana Prabhu | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，10： | 2 |
| 3 | Effect of reaction medium on radical copolymerization of acrylonitrile with vinyl acids显示文摘 | Pushpa Bajaj T V Sreekumar Kushal SEN | 2001 | J Appl Polym Sci2001，79，： | 1 |
| 4 | Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling 显示文摘 | Kushal S Brooke BL Hencbey LK | 2013 | Proc Natl Aead Sci USA2013，110，15： | 1 |
| 5 | Effect of reaction medium on radical copolymerization of acrylonitrile with vinyl acids显示文摘 | Pushpa Bajaj T V Sreekumar Kushal Sen | 2001 | Journal of Applied Polymer Science2001，79，： | 1 |
| 6 | Spectrum of complications associated with Plasmodium vivax infection in a tertiary hospital in South-Western India显示文摘Objective:To determine the range and incidence of complications associated with Plasmodium vivax[P.vivax) malaria.Methods:A retrospective analysis was performed of all patients of P.vivax malaria admitted in kasturba Medical College.Manipal between January and December,2010.Patients with mixed malarial infection were excluded by appropriate tests. Clinical presentation and laboratory parameters were studied.Results:Medical records of 213 individuals who satisfied the inclusion criteria were reviewed.Anaemia was seen in 65 (30.5%),leucopenia in 38(17.8%]and thrombocytopenia in 184(86.4%l patients.Aspartate and alanine aminotransferases were elevated in 86(40.4%).and 89(41.9%) patients respectively. Hypoalbuminemia was observed in 157(73.6%) cases.Elevated serum creatinine was noted in in 59(27.5%) patients.Creatine kinase was elevated in 30 nut of 59 patients(50.8%).Overall.107 (50.2%) patients fulfilled WHO criteria for sever=e malaria.None of the patients succumbed to the disease.Conclusion:P.vivax malaria is a potentially severe disease,and the term ’ benign' tertian malaria is a misnomer.Despite significant morbidity,with timely and appropriate treatment P.rirax malaria has an excellent outcome. | Kushal Naha Sowjanya Dasari Mukhyaprana Prabhu | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，1： | 1 |
| 7 | Smaller coresets for k-median and k-means clustering显示文摘 | Har-Peled S Kushal A | 2007 | Discrete Comput Geom2007，37，： | 1 |
| 8 | Keratomycosis:clinical and Microbiologic Experiencewith dematiaceous Fungi 显示文摘 | Garg Prashant Gopinathan Usha Choudhary Kushal | 2000 | Ophthalmology2000，107，： | 1 |
| 9 | Fauh diagnosis and isolation in aircraft gas turbine engines显示文摘 | SOUMIK SARKAR KUSHAL MUKHERJEE ASOK RAY | 2008 | Ameri- can Control Conference2008，11，6： | 1 |
| 10 | Effect of chemical treatments on keeping quality and sugar contents in rose and gladiolus显示文摘 | KUSHAL SINGH PARMINDER SINGH MANDHIR SINGH | 2004 | Scientific Horticulture2004，，9： | 1 |
| 11 | 显示文摘 | Dhake Kishor P’Bhatte Kushal D Wagh Yogesh S | 2012 | Biotechnology and Bioprocess Engineering2012，17，5： | 1 |
| 12 | Seed mycoflora of sunflower and its effect on seed and plant health显示文摘 | Kushal R Saharan G S | 1994 | Indian Journal of Mycology and Plant Pathology1994，24，1： | 1 |
| 13 | Effect of reaction medium on radical copolymerization of acrylonitrile with vinyl acids显示文摘 | Pushpa Bajaj Sreekumar T V Kushal S E N | 2001 | J Appl Po lym Sci2001，79，： | 1 |
| 14 | Nanosize Co 3 O 4 as a novel, robust, efficient and recyclable catalyst for A 3 -coupling reaction of propargylamines显示文摘 | Kushal D. Bhatte Dinesh N. Sawant Krishna M. Deshmukh Bhalchandra M. Bhanage | 2011 | Catalysis Communications2011，，1： | 1 |
| 15 | Smaller corsets for k-median and k-means clustering显示文摘 | Har-Peled s Kushal A | 2007 | Discrete and Computational Geometry2007，37，1： | 1 |
| 16 | Effect of reaction medium on radical copolymerization of acrylonitrile with vinyl acids 显示文摘 | PUSHPA BAJAJ SREEKUMAR T V KUSHAL SEN | 2001 | Journal of Applied Polymer Science2001，79，： | 1 |
| 17 | Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models显示文摘 | Taylor James G Cheuk Adam T Tsang Patricia S Chung Joon-Yong Song Young K Desai Krupa Yu Yanlin Chen Qing-Rong Shah Kushal Youngblood Victoria Fang Jun Kim Su Young Yeung Choh Helman Lee J Mendoza Arnulfo Ngo Vu Staudt Louis M Wei Jun S | 2009 | Journal of Clinical Investigation2009，，11： | 1 |
| 18 | Relating Maxwell's demon and quantitative analysis of information leakage for practical imperative programs显示文摘Shannon observed the relation between information entropy and Maxwell demon experiment to come up with information entropy formula. After that, Shannon's entropy formula is widely used to measure information leakage in imperative programs. But in the present work, our aim is to go in a reverse direction and try to find possible Maxwell's demon experimental setup for contemporary practical imperative programs in which variations of Shannon's entropy formula has been applied to measure the information leakage. To establish the relation between the second principle of thermodynamics and quantitative analysis of information leakage, present work models contemporary variations of imperative programs in terms of Maxwell's demon experimental setup. In the present work five contemporary variations of imperative program related to information quantification are identified. They are:(i) information leakage in imperative program,(ii) imperative multithreaded program,(iii) point to point leakage in the imperative program,(iv) imperative program with infinite observation,and(v) imperative program in the SOA-based environment. For these variations, minimal work required by an attacker to gain the secret is also calculated using historical Maxwell's demon experiment. To model the experimental setup of Maxwell's demon, non-interference security policy is used. In the present work, imperative programs with one-bit secret information have been considered to avoid the complexity. The findings of the present work from the history of physics can be utilized in many areas related to information flow of physical computing, nano-computing, quantum computing,biological computing, energy dissipation in computing, and computing power analysis. | Kushal Anjaria Arun Mishra | 2017 | Chinese Physics B2017，26，10： | 1 |
| 19 | Wavelet - based feature extraction using probabilistic finite state automata for pattern classification 显示文摘 | Xin Jin Shalabh Gupta Kushal Mukherjee | 2011 | Pattern Recognition2011，44，： | 1 |
| 20 | Myopericytoma of the thoracic spine: a case report and review of literature 显示文摘 | Nikunj A Kushal N | 2013 | The spine journal: of- ficial journal of the North American Spine Society2013，13，11： | 1 |
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