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| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Removal of ammonia nitrogen by the precipitation method,an the example of some selected wastewaters显示文摘 | Zdybiewska M W and Kula B | 1991 | Water Science and Technology1991，24，7： | 1 |
| 3 | Investigating expression systems for the stable large-scale production of recombinant L-leucine-dehydro- genase from Bacillus cereus in Escherichia eoli显示文摘 | Ansorge M B Kula M R | 2000 | Appl Microbi- ol Biotechnol2000，53，6： | 1 |
| 4 | Association of polymorphism of LT alpha and TNF genes with Graves' disease 显示文摘 | Kula D Jurecka-Tuleji B Gubala E | 2001 | Folia Histochem Cytobiol2001，392，： | 1 |
| 5 | Association between polymorphisms in the TSHR gene and Graves' orbitopathy显示文摘 | Jurecka-Lubieniecka B Ploski R Kula D | 2014 | PLoS One2014，9，10： | 1 |
| 6 | Removal of ammonia Nitrogen by the precipitation method,on the example of some selected waste waters显示文摘 | Zdybiewska M W Kula B | 1991 | Water Science and Technology1991，24，7： | 1 |
| 7 | Association between polymorphisms in the TSHR gene and Graves' orbi- topathy显示文摘 | Jurecka-Lubieniecka B Ploski R Kula D | 2014 | PLoSOne2014，9，10： | 1 |
| 8 | Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves' disease: the impact of DRB1 ^* 07 显示文摘 | Kula D Bednarczuk T Jurecka-Lubieniecka B | 2006 | Thyroid2006，16，5： | 1 |
| 9 | Effects of power freqency electrical field upon some low-molecular constituents in the guinea pigblood显示文摘 | KULA B WARDAS M | 1992 | Revue Roumaine de Biochimie1992，29，： | 1 |
| 10 | Effect of magnet- ic field on the activity of hyaluronidase and 13 -D - glukuronidase and the level hyaluronic acid and chondroitin sulfates in rat liver显示文摘 | KULA B GRZESIK J WARDAS M | 1991 | ANNALS Academy of Medicine Singa- pore1991，24，： | 1 |
| 11 | Electroanalytical characteristics of antipsychotic pharmaceuticals and serum samples on solid electrodes显示文摘 | Kula D Gumustas M Uslu B | 2010 | Talanta2010，82，1： | 1 |
| 12 | Association of NFKB1 -94ins/del ATTG promoter polymorphism with susceptibility to and phenotype of Graves' disease 显示文摘 | Kurylowicz A Hiromatsu Y Jurecka-Lubieniecka B Kula D Kowalska M Ichimura M | 2007 | Genes Immun2007，8，7： | 1 |
| 13 | Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves disease: the impact of DRB1*07显示文摘 | KULA D BEDNARCZUK T JURECKA-LUBIENIECKA B | 2006 | Thyroid2006，16，5： | 1 |
| 14 | Associa- tion between age at diagnosis of Gravesr disease and vari ants in genes involved in immune response显示文摘 | Jurecka-Lubieniecka B Ploski R Kula D | 2013 | PLoS One2013，8，59： | 1 |
| 15 | Sequential membrane-based purification of proteins, applying the concept ofmunidimentional liquid chromatography显示文摘 | Champluvier B Kula M R | 1992 | Bioseparation1992，，2： | 1 |
| 16 | Investigating expression systems for the stable large-scale production of recombinant L-leucinedehydrogenase from Bacillus cereus in Escherichia coli显示文摘 | Ansorge M B Kula M R | 2000 | Applied microbiology and biotechnology2000，53，6： | 1 |
| 17 | Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves' disease:the impact of DRB1 *07显示文摘 | Kula D Bednarczuk T Jurecka-Lubieniecka B | 2006 | Thyroid2006，16，5： | 1 |
| 18 | Association between age at diagnosis of Graves' disease and variants in genes involved in immune response 显示文摘 | JURECKA-LUBIENIECKA B PLOSKI R KULA D | 2013 | PLoS One2013，8，59： | 1 |
| 19 | Association of polymorphism of LT alpha and TNF genes with Graves'disease显示文摘 | Kula D Jurecka B Gubala E | 2001 | Folia Histochem Cytobiol2001，39，2： | 1 |
| 20 | Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors 显示文摘 | Porst H Brock G B Kula K | 2012 | J Androl2012，33，6： | 1 |
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