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| 1 | Bile acid increases expression of the histamine-producing enzyme,histidine decarboxylase,in gastric cells显示文摘AIM:To investigate the effect of bile acid on the expression of histidine decarboxylase(HDC),which is a major enzyme involved in histamine production,and gene expression of gastric transcription factors upon cooperative activation.METHODS:HDC expression was examined by immunohistochemistry,reverse transcriptase polymerase chain reaction,and promoter assay in human gastric precancerous tissues,normal stomach tissue,and gastric cancer cell lines.The relationship between gastric precancerous state and HDC expression induced by bile acid was determined.The association between the expression of HDC and various specific transcription factors in gastric cells was also evaluated.MKN45 and AGS human gastric carcinoma cell lines were transfected with farnesoid X receptor(FXR),small heterodimer partner(SHP),and caudal-type homeodomain transcription factor(CDX)1 expression plasmids.The effects of various transcription factors on HDC expression were monitored by luciferase-reporter promoter assay.RESULTS:Histamine production and secretion in the stomach play critical roles in gastric acid secretion and in the pathogenesis of gastric diseases.Here,we show that bile acid increased the expression of HDC,which is a rate-limiting enzyme of the histamine production pathway.FXR was found to be a primary regulatory transcription factor for bile acid-induced HDC expression.In addition,the transcription factors CDX1 and SHP synergistically enhanced bile acid-induced elevation of HDC gene expression.We confirmed similar expression patterns for HDC,CDX1,and SHP in patient tissues.CONCLUSION:HDC production in the stomach is associated with bile acid exposure and its related transcriptional regulation network of FXR,SHP,and CDX1. | Hye Jin Ku Hye Young Kim Hyeong Hoe Kim Hee Ju Park Jae Hun Cheong | 2014 | World Journal of Gastroenterology2014，20，1： | 3 |
| 2 | MBE growth of high - quality ZnO films on epi - GaN 显示文摘 | Hang Ju Ko Yefan Chen Soon Ku Hong | 2000 | Journal of Crystal Growth2000，209，： | 1 |
| 3 | Time-Space Efficient Exponentiation over GF ( 2m ) 显示文摘 | Ku Kyo-Min Ha Kyeoung Ju Yoo Kee-Young | 2003 | ICCSA2003，，1： | 1 |
| 4 | Obstetric outcomes after uterine myomec- tomy : Laparoscopic versus laparotomic approach 显示文摘 | Myo SK You KU Ju YK | 2013 | Obstet Gynecol Sci2013，56，6： | 1 |
| 5 | Isoliquiritige- nin isolated from Glycyrrhiza uralensis protects neuronal ceils against glutamate-induced mitochondrial dysfunction 显示文摘 | Eun-Ju Yang Ju Sik Min Hyun-Yeong Ku | 2012 | Bio- chem Bioph Res Co2012，421，： | 1 |
| 6 | Bioelectrocatalytic detection of glycated hemoglobin (HbA 1c ) based on the competitive binding of target and signaling glycoproteins to a boronate-modified surface显示文摘 | Seung Yeon Song Yong Duk Han Yoo Min Park Chi Yong Jeong Yong Ju Yang Moo Sub Kim Yunhee Ku Hyun C. Yoon | 2012 | Biosensors and Bioelectronics2012，，1： | 1 |
| 7 | Study on MgO Buffer in ZnO Layers Grown by Plasma-assisted Molecular Beam Epitaxy on Al2O3(0001)显示文摘 | Agus Setiawan Hang Ju Ko Soon Ku Hong | 2003 | Thin Solid Films2003，445，2： | 1 |
| 8 | MBE growth of high-quality ZnO films on epi-GaN 显示文摘 | Hang Ju Ko Yefan Chen Soon Ku Hong | 2000 | Journal of Crystal Growth2000，209，4： | 1 |
| 9 | Nano-Geology and Unconventional Oil and Gas显示文摘Numerous Striking achievements have been made in micro and macro geology after the development for hundreds of years.Two trends branches of geology are divided into microcosmic nano-geology and macroeconomic astrono-geology with the enormous technology progress.The unique characteristics related to the nano-particles and nano-pores may be significant | JU Yiwen LU Shuangfang SUN Yan TAN Fengqi WANG Guochang HAN Ku BAO Yuan LI Qingguang | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 1 |
| 10 | Formation of interfacial brittle phases sigma phase and IMC in hybrid titanium-to-stainless steel joint显示文摘The microstructures of the brazed joints for commercially pure Ti and stainless steel were investigated by the applications of various filler alloys including Ag-, Ti-, Zr- and Ni-based alloys. Generally, the dissimilar joints between Ti and stainless steel were dominated by the Ti-based intermetallic compounds (IMCs), e.g. (Ti, Zr)2(Fe, Ni), TiFe, TiCu, and Ti2(Fe, Ni), due to a significant dissolution of Ti from the base metal. The (Fe-Cr) σ phase was also observed near the stainless steel due to a segregation of Cr into the interface region. This research demonstrates empirically that the brittleness of the Ti and stainless steel joint can not be avoided only by applying single braze alloy or single insert metal, and thus an introduction of additional suitable interlayer between the filler alloy and the base metal is necessary to prevent the brittleness of the joint. | Min Ku LEE Jung Gu LEE Jong Keuk LEE Sung Mo HONG Sang Hoon LEE Jin Ju PARK Jae Woo KIM Chang Kyu RHEE | 2011 | Transactions of Nonferrous Metals Society of China2011，21，A01： | 1 |
| 11 | Preparation and prop- erties of polyimide/aluminum nitride显示文摘 | Shu - hui Xie Bao - ku Zhu Ju - biao Li | | 0，，23： | 1 |
| 12 | Defect characterization in epitaxial ZnO/epi GaN/Al2O3 heterostructures: Transmission electron microscopy and triple-axis X-ray diractometry显示文摘 | Soon Ku Hong Hang Ju Ko Chen Yefan | 2000 | J Crystal Growth2000，209，23： | 1 |
| 13 | MBE growth of high-quality Zn0 films on epi-GaN显示文摘 | Hang Ju Ko Yefan Chen Soon Ku Hong | 2000 | Journal of Crystal Growth2000，209，： | 1 |
| 14 | MBE Growth of High-quality ZnO Films on Epi-GaN 显示文摘 | Yefan Chen Hong Soon Ku Takafumi Yao | 2000 | Journal of Crystal Growth2000，209，： | 1 |
| 15 | A Challenge in Molecular Beam Epitaxy of ZnO: Control of Material Properties by Interface Engineering 显示文摘 | Hong Soon Ku Chen Yefen Yao Takafumi | 2002 | Thin Solid Films2002，409，： | 1 |
| 16 | MBE growth of high-quality ZnO films on epi-GaN显示文摘 | ChenYefan Ku Hong Soon | 2000 | J Cryst Growth2000，209，4： | 1 |
| 17 | Control and characterization of ZnO/GaN heterointerfaces in plasma- assisted MBE- grown ZnO films on GaN/Al2O3 显示文摘 | Hong Soon- ku Ko Hang- ju Chen Ye- fan | 2000 | Applied Surface Science2000，，： | 1 |
| 18 | The preventive effect of systemic treatment with interferonalpha 2B for intertility form mumps orchitis 显示文摘 | Ku Ju Kim YH Jeon YS | 1999 | BJV Int1999，84，7： | 1 |
| 19 | Radial Pulse and Electrocardiography Modulation by Mild Thermal Stresses Applied to Feet: An Exploratory Study with Randomized, Crossover Design显示文摘Objective:To investigate the changes in radial pulse induced by thermal stresses(TSs).Methods:Sixty subjects were enrolled.Using an open-label,2x2 crossover randomization design,both feet of each subject were immersed in 15%:water for cold stress(CS)and in 40 X:water for heat stress(HS)for 5 min each.Radial pulse,respiration and electrocardiogram(ECG)signals were recorded before,during and immediately after the TSs.Results:The an alysis of heart rate variability revealed that CS in creased the low-freque ncy(LF)and high-frequency(HF)components(P<0.05)and that HS reduced the LF and HF components(P<0.01).Both TSs reduced the normalized LF,increased the normalized HF,and reduced the LF/HF ratio.The differences in the ECG signals were more dominant during the TS sessions,but those in the radial pulse signals became more domi nant immediately after the TS sessi ons.CS decreased the pulse depth(P<0.01)and in creased the radial augme ntation in dex(P<0.1),and HS in creased the pulse pressure(P<0.1)and sube ndocardial viability ratio(P<0.01).There were no significant differences in pulse rate during the three time sequences of each TS.The respiration rate was increased(P<0.1),and the pulse rate per respiration(P/R ratio)was significantly decreased(P<0.05)with CS.The HF region(10-30 Hz)of the pulse spectral density was suppressed during both TSs.Conclusions:CS induced vasoconstriction and sympathetic reactions,and HS induced vasodilation and parasympathetic reacti ons.Based on defi nitions used in pulse diag no sis,we made the novel discoveries that the pulse became slower(decreased P/R ratio),more floating and tenser under CS and that the HF region of the spectral power decreased significantly under both TSs. | Jang-Han Bae Boncho Ku Young Ju Jeon Hyunho Kim Jihye Kim Haebeom Lee Jong Yeol Kim Jaeuk U.Kim | 2020 | Chinese Journal of Integrative Medicine2020，26，4： | 0 |
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