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| 1 | Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications显示文摘Rheumatoid arthritis(RA) is an autoimmune disease, resulting in a chronic, systemic inflammatory disorder. It may affect many tissues and organs, but it primarily affects the flexible joints. In clinical practice patient care generates many questions about diagnosis, prognosis, and treatment. It is challenging for health care specialists to keep up to date with the medical literature. This review summarizes the pathogenesis, the polymorphisms of interleukin and interleukin genes and the standard available and possible future immunologictargets for RA treatment. The identification of diseaseassociated interleukin and interleukin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for RA pathogenesis. The knowledge of the complex genetic background may prove useful for developing novel therapies and making personalized medicine based on the individual's genetics. | Lili Magyari Dalma Varszegi Erzsebet Kovesdi Patricia Sarlos Bernadett Farago Andras Javorhazy Katalin Sumegi Zsolt Banfai Bela Melegh | 2014 | World Journal of Orthopedics2014，5，4： | 17 |
| 2 | Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature显示文摘Ulcerative colitis(UC) is one of the main types of inflammatory bowel disease, which is caused by dysregulated immune responses in genetically predisposed individuals. Several genetic factors, including interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes play central role in mediating and modulating the inflammation in the human body, thereby these can be the main cause of development of the disease. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but summarized literature is exiguous for challenge health specialist that can used in the clinical practice nowadays. This review summarizes the current literature on inflammationrelated genetic polymorphisms which are associated with UC. We performed an electronic search of Pubmed Database among publications of the last 10 years, using the following medical subject heading terms: UC, ulcerative colitis, inflammation, genes, polymorphisms, and susceptibility. | Patricia Sarlos Erzsebet Kovesdi Lili Magyari Zsolt Banfai Andras Szabo Andras Javorhazy Bela Melegh | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 15 |
| 3 | Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility显示文摘Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),represents a group of chronic inflammatory disorders caused by dysregulated immune responses in genetically predisposed individuals.Genetic markers are associated with disease phenotype and long-term evolution,but their value in everyday clinical practice is limited at the moment.IBD has a clear immunological background and interleukins play key role in the process.Almost130 original papers were revised including meta-analysis.It is clear these data are very important for understanding the base of the disease,especially in terms of clinical utility and validity,but text often do not available for the doctors use these in the clinical practice nowadays.We conducted a systematic review of the current literature on interleukin and interleukin receptor gene polymorphisms associated with IBD,performing an electronic search of PubMed Database from publications of the last 10 years,and used the following medical subject heading terms and/or text words:IBD,CD,UC,interleukins and polymorphisms. | Lili Magyari Erzsebet Kovesdi Patricia Sarlos Andras Javorhazy Katalin Sumegi Bela Melegh | 2014 | World Journal of Gastroenterology2014，20，12： | 8 |
| 4 | 急性心肌梗死后出院钾与血钾异常和不良事件的关系显示文摘急性心肌梗死(acute myocardial infarction,AMI)患者中的血钾异常和相关临床结局的发生率在现实世界尚未知,可能与随机对照试验的受控环境有关。Xu等连续纳入SWEDEHEART登记研究在2006—2011年间的AMI幸存者,并在出院时测定血钾浓度。 | 刘莉 叶鹏 Xu H Faxén J Szummer K Trevisan M Kovesdy CP Jernberg T Carrero JJ | 2018 | 中华高血压杂志2018，26，10： | 5 |
| 5 | IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis显示文摘AIM To investigate the association of seven single nucleotide polymorphisms(SNPs) of the IL23 R gene with the clinical picture of ulcerative colitis(UC). METHODS Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the alleles of seven SNPs of IL23 R gene(rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511).RESULTS Four out of seven analyzed SNPs had statistically significant influence on the clinical picture of UC. Two SNPs were associated with greater colonic extension(rs2201841 P = 0.0084; rs10489629 P = 0.0405). For two of the SNPs, there was more frequently need for operations (rs2201841 P = 0.0348, OR = 8.0; rs10889677 P = 0.0347, OR = 8.0). The rs2201841 showed to be a risk factor for the development of iron deficiency (P = 0.0388, OR = 6.1837). For patients with the rs10889677, a therapy with azathioprine was more frequently necessary(P = 0.0116, OR = 6.1707). Patients with rs10489629 SNP had a lower risk for weight loss(P = 0.0169, OR = 0.3394). Carriers of the heterozygous variant had a higher risk for an extended disease (P = 0.0284). The rs7517847 showed a protective character leading to mild bowel movements. Three SNPs demonstrated no statistically significant influence on any examined clinical features of UC.CONCLUSION We demonstrated susceptible or protective character of the investigated IL23 R SNPs on the phenotype of UC, confirming the genetic association. | Sarah Fischer Erzsébet Kovesdi Lili Magyari Veronika Csongei Kinga Hadzsiev Béla Melegh Péter Hegyi Patrícia Sarlós | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 6 | Hyponatremia, Hypernatremia, and Mortality in Patients With Chronic Kidney Disease With and Without Congestive Heart Failure显示文摘 | Csaba P. Kovesdy Evan H. Lott Jun Ling Lu Sandra M. Malakauskas Jennie Z. Ma Miklos Z. Molnar Kamyar Kalantar-Zadeh | 2012 | Circulation2012，，5： | 2 |
| 7 | Novel targets and new potential:developments in the treatment of inflammation in chronic kidney disease显示文摘 | Csaba P Kovesdy Kamyar Kalantar-Zadeh | | 0，，04： | 1 |
| 8 | The effect of enriched environment on the outcome of traumatic brain injury; a behavioral, proteomics, and histological study 显示文摘 | Kovesdi E Gyorgy A B Kwon S K | 2011 | Front Neurosci2011，5，： | 1 |
| 9 | Fibroblast growth factor-23:what we know,what we don't know,and what we need to know显示文摘 | Kovesdy CP Quarles LD | 2013 | Nephrol Dial Transplant2013，28，9： | 1 |
| 10 | Fluid retention is associated with cardiovascular mortality in patients undergoing longterm hemodialysis显示文摘 | Kalantar Zadeh K Regidor DL Kovesdy CP | 2009 | Circu- lation2009，119，5： | 1 |
| 11 | Serum and dialysate potassium concentrations and survival in hemodialysis patients显示文摘 | Kovesdy CP Regidor DL Mehrotra R et at | 2007 | Clin J Am Soc Nephrol2007，2，5： | 1 |
| 12 | Combined high serum ferritin and low iron saturation in hemodialysis patients:the role of inflammation显示文摘 | RAMBOD M KOVESDY C P KALANTAR-ZADEH K | 2008 | Clin J Am Soc Nephrol2008，3，6： | 1 |
| 13 | Gene therapy for collateral vessel development 显示文摘 | MELILLO G SCOCCIANTI M KOVESDI I | 1997 | Cardiovas- cular Research1997，35，3： | 1 |
| 14 | Glycemic control and cardiovascular mortality in hemodialysis patients with diabetes: a 6 - year cohort study显示文摘 | Ricks J Molnar MZ Kovesdy CP | 2012 | Diabetes2012，61，3： | 1 |
| 15 | Malnutrition-inflammation score for risk stratification of patients with CKD:is it the promised gold standard?显示文摘 | RAMBOD M KOVESDY C P KALANTAR ZADEH K | 2008 | Nat Clin Pract Nephrol2008，4，7： | 1 |
| 16 | Gene therapy for collateral vessel development显示文摘 | Melillo G Scoccianti M Kovesdi I Safi J Jr Riccioni T Capogrossi MC | 1997 | Cardiovasc Res1997，35，3： | 1 |
| 17 | Association of a- nemia with outcomes in men with moderate and severe chronic kidney disease 显示文摘 | Kovesdy CP Trivedi BK Kalantar-Zadeh K | 2006 | Kidney Int2006，69，3： | 1 |
| 18 | Fluid retention is associated with cardiovascular mortality in patients undergoing long term hemodialysis 显示文摘 | Kalantar-Zadeh K Regidor DL Kovesdy CP | 2009 | Circulation2009，119，5： | 1 |
| 19 | Combined High Serum Ferritin and Low Iron Saturation in Hemodialysis Patients:The Role of Inflammation显示文摘 | Rambod M Kovesdy P Kalantar-Zadeh K | | 0，，06： | 1 |
| 20 | Glycemic control in diabetic CKD patients: where do we stand? 显示文摘 | KOVESDY C P SHARMA K KALANTAR--ZADEH K | 2008 | AmJ Kidney Dis2008，52，4： | 1 |
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