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| 1 | Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis显示文摘AIM: To determine the efficacy of Mac-2 binding protein(Mac-2bp) for diagnosis of chronic pancreatitis.METHODS: Fifty-nine healthy volunteers(HV), 162 patients with chronic pancreatitis(CP), and 94 patients with pancreatic ductal adenocarcinoma(PDAC) were enrolled in this study. We measured serum Mac-2bp using our developed enzyme-linked immunosorbent assay kit. Additional biochemical variables were measured using an automated analyzer(including aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, triglyceride, C-reactive protein, and amylase levels) or chemiluminescent enzyme immunoassay(carbohydrate antigen 19-9 and carcinoembryonic antigen). The ability of Mac-2bp to predict CP diagnosis accurately was assessed using receiver operating characteristic(ROC) analyses.RESULTS: Serum Mac-2bp levels were significantly increased in CP patients compared to HV(P < 0.0001) and PDAC patients(P < 0.0001). Area under the ROC curve values of Mac-2bp for the discrimination of CP from HV and PDAC were 0.727 and 0.784, respectively. Multivariate analyses demonstrated that serum Mac-2bp levels were independent determinants for CP diagnosis from HV and PDAC patients. Immunohistological staining showed that Mac-2bp was expressed faintly in the pancreas tissues of both CP and PDAC patients. Serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, and triglyceride levels were significantly higher in patients with CP or PDAC. Serum Mac-2bp levels were highly correlated with protein levels of alanine aminotransferase, γ-glutamyltransferase, and C-reactive protein, but not amylase, suggesting that the damaged liver produces Mac-2bp. CONCLUSION: Measurement of serum Mac-2bp may be a novel and useful biomarker for CP diagnosis as well as liver fibrosis in the general population. | Tomohiro Maekawa Yoshihiro Kamada Yusuke Ebisutani Makiko Ueda Tomoki Hata Koichi Kawamoto Shinji Takamatsu Kayo Mizutani Mayuka Shimomura Tomoaki Sobajima Hironobu Fujii Kotarosumitomo Nakayama Kimihiro Nishino Makoto Yamada Takashi Kumada Toshifumi Ito Hidetoshi Eguchi Hiroaki Nagano Eiji Miyoshi | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 2 | Requirement of Protocol Biopsy Before and After Complete Cessation of Immunosuppression After Liver Transplantation显示文摘 | Mami Yoshitomi Takaaki Koshiba Hironori Haga Ying Li Xiangdong Zhao Donghua Cheng Aya Miyagawa Hiromi Sakashita Tatsuaki Tsuruyama Hidenori Ohe Mikiko Ueda Shinya Okamoto Hiroto Egawa Kathryn Wood Shimon Sakaguchi Toshiaki Manabe Koichi Tanaka Shinji Uemo | 2009 | Transplantation2009，，4： | 2 |
| 3 | Anatomical variations and surgical strategies in right lobe living donor liver transplantation: lessons from 120 cases1显示文摘 | Taro Nakamura Koichi Tanaka Tetsuya Kiuchi Mureo Kasahara Fumitaka Oike Mikiko Ueda Satoshi Kaihara Hiroto Egawa Ilgin Ozden Nobuaki Kobayashi Shinji Uemoto | 2002 | Transplantation2002，，12： | 1 |
| 4 | Occupational allergic hazards of agricultural chemicals and its prevention显示文摘 | ATSUSHI UEDA KOICHI HARADA SHOKO OHMORIETAL | 2005 | Journal of Environmental & Dccupational Medicine2005，22，4： | 1 |
| 5 | Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation显示文摘 | Takashi Ito Yasutsugu Takada Mikiko Ueda Hironori Haga Yoji Maetani Fumitaka Oike Kohei Ogawa Seisuke Sakamoto Yasuhiro Ogura Hiroto Egawa Koichi Tanaka Shinji Uemoto | 2007 | Liver Transpl2007，，12： | 1 |
| 6 | Effects of carbon content on wear property in pearlitic steels 显示文摘 | Masaharu Ueda Koichi Uchino Akira Kobayashi | 2002 | Wear2002，253，12： | 1 |
| 7 | Gallbladder carcinoma with osteoclast-like giant cells显示文摘 | Tomotaka Akatsu Kaori Kameyama Shigeyuki Kawachi Minoru Tanabe Koichi Aiura Go Wakabayashi Masakazu Ueda Motohide Shimazu Masaki Kitajima | 2006 | Journal of Gastroenterology2006，，1： | 1 |
| 8 | Anti-High-Mobility Group Box Chromosomal Protein 1 Antibodies Improve Survival of Rats with Sepsis显示文摘 | Koichi Suda Yuko Kitagawa Soji Ozawa Yoshiro Saikawa Masakazu Ueda Masahito Ebina Shingo Yamada Satoru Hashimoto Shinji Fukata Edward Abraham Ikuro Maruyama Masaki Kitajima Akitoshi Ishizaka | 2006 | World Journal of Surgery2006，，9： | 1 |
| 9 | Deterioration of Water Ballast Tank Coating Systems by Active Substances in Ballast Water Management Systems显示文摘 | Ryuji Kojima Michiaki Ikai Toshiaki Shibata Koichi Ueda | 2014 | Journal of Shipping and Ocean Engineering2014，4，9： | 1 |
| 10 | Catalytic Combustion of Volatile Organic Compounds on Supported Precious Metal Catalysts显示文摘 | Tatsuya Takeguchi Satoshi Aoyama Junya Ueda Ryuji Kikuchi Koichi Eguchi | 2003 | Topics in Catalysis (-)2003，，1： | 1 |
| 11 | Immunological Impact of Neoadjuvant Chemoradiotherapy in Patients with Borderline Resectable Pancreatic Ductal Adenocarcinoma显示文摘 | Yuki Homma Koichi Taniguchi Takashi Murakami Kazuya Nakagawa Masatoshi Nakazawa Ryusei Matsuyama Ryutaro Mori Kazuhisa Takeda Michio Ueda Yasushi Ichikawa Kuniya Tanaka Itaru Endo | 2014 | Annals of Surgical Oncology2014，，2： | 1 |
| 12 | Identification of a Hashimoto Thyroiditis Susceptibility Locus Via a Genome-wide Comparison With Graves? Disease显示文摘 | Daisuke Oryoji Sho Ueda Ken Yamamoto Jaeduk Yoshimura Noh Ken Okamura Mitsuhiko Noda Natsuko Watanabe Ai Yoshihara Koichi Ito Takehiko Sasazuki | 2015 | The Journal of Clinical Endocrinology & Metabolism2015，，2： | 1 |
| 13 | P2X4 receptor expression in a rat model of trigeminal neuropathic pain显示文摘 | Kunihiro Nakai Aya Nakae Sosuke Oba Takashi Mashimo Koichi Ueda | 2010 | NeuroReport2010，，8： | 1 |
| 14 | Sulfatide Protects Rat Skin Flaps Against Lschemia-Reperfusion Injury显示文摘 | KOICHI UEDA MASUMI NOZAWA MASAYUKI | 1998 | Plast Reconstr Surg1998，80，5： | 1 |
| 15 | A Warning Index Used in Prescreening for Alzheimer’s Disease, Based on Self-Reported Cognitive Deficits and Vascular Risk Factors for Dementia in Elderly Patients with Type 2 Diabetes显示文摘 | Toshioki Matsuzawa Toshihiro Takata Koichi Yokono Hiroo Ueda Kensuke Moriwaki Isao Kamae Katsuya Urakami Takashi Sakurai Hiroyuki Umegaki | 2012 | International Journal of Alzheimer’s Disease2012，，： | 1 |
| 16 | Living-donor liver transplantation with monosegments显示文摘 | Mureo Kasahara Satoshi Kaihara Fumitaka Oike Takashi Ito Yasuhiro Fujimoto Yasuhiro Ogura Kohei Ogawa Mikiko Ueda Mohamed Rela Nigel D Heaton Koichi Tanaka | 2003 | Transplantation2003，，4： | 1 |
| 17 | Platelet-derived endothelial cell growth factor predicts of progression and recurrence in primary epithelial ovarian cancer显示文摘 | Yoh Watanabe Hidekatsu Nakai Haruhiko Ueda Koichi Nozaki Hiroshi Hoshiai Kiichiro Noda | 2003 | Cancer Letters2003，，2： | 1 |
| 18 | Effects of atorvastatin on inflammation and oxidative stress显示文摘 | Masaya Sugiyama Masuo Ohashi Hiroyuki Takase Koichi Sato Ryuzo Ueda Yasuaki Dohi | 2005 | Heart and Vessels2005，，4： | 1 |
| 19 | Assessment of health-promoting lifestyle profile in Japanese university students显示文摘 | Chang-Nian Wei Koichi Harada Kimiyo Ueda Kumiko Fukumoto Keiko Minamoto Atsushi Ueda | 2012 | Environmental Health and Preventive Medicine2012，，3： | 1 |
| 20 | Pseudoaneurysm of the Cystic Artery Secondary to Cholecystitis as a Cause of Hemobilia: Report of a Case显示文摘 | Tomotaka Akatsu Minoru Tanabe Tomohiro Shimizu Kan Handa Shigeyuki Kawachi Koichi Aiura Masakazu Ueda Motohide Shimazu Masaki Kitajima | 2007 | Surgery Today2007，，5： | 1 |
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