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38篇 您的检索式：作者名="Knab M"

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	题名	作者	年代	出处	被引量
1	Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase显示文摘The interplay between inflammation and cancer progression is a growing area of research. A combination of clinical, epidemiological, and basic science investigations indicate that there is a relationship between inflammatory changes in the pancreas and neoplastic progression. Diets high in ω-6 polyunsaturated fatty acids provide increased substrate for arachidonic acid metabolism by cyclooxygenase-2(COX-2) and 5-lipoxygenase(5-LOX) to form eicosanoids. These eicosanoids directly contribute to pancreatic cancer cell proliferation. Both COX-2 and 5-LOX are upregulated in multiple cancer types, including pancreatic cancer. In vitro studies using pancreatic cancer cell lines have demonstrated upregulation of COX-2 and 5-LOX at both the mRNA and protein levels. When COX-2 and 5-LOX are blocked via a variety of mechanisms, cancer cell proliferation is abrogated both in vitro and in vivo.The mechanism of COX-2 has been shown to include effects on apoptosis as well as angiogenesis. 5-LOX has been implicated in apoptosis. The use of COX-2 and 5-LOX inhibitors in clinical studies in patients with pancreatic cancer has been limited. Patient enrollment has been restricted to those with advanced disease which makes evaluation of these drugs as chemopreventive agents difficult. COX-2 and 5-LOX expression have been shown to be present during the early neoplastic changes of pancreatic cancer, well before progression to invasive disease. This indicates that the ideal role for these interventions is early in the disease process as preventive agents, perhaps in patients with chronic pancreatitis or hereditary pancreatitis.	Lawrence M Knab Paul J Grippo David J Bentrem	2014	World Journal of Gastroenterology2014，20，31：	9
2	Subcortical structures involved in pain processing: evidence from single-trial fMRI 显示文摘	Bingel U Quante M Knab R	2002	Pain2002，99，：	1
3	Magnetic susceptibility napping of roadside pollution 显示文摘	Hoffmann V Knab M Apple E	1999	Journal of Geochemical Exploration1999，66，：	1
4	Single trial fMRI reveals significant contralateral bias in responses to laser pain within thalamus and somatosensory cortices显示文摘	Bingel U Quante M Knab R	2003	Neuroimage2003，18，3：	1
5	Subcortical structures involved in pain processing: evidence from single-trial fMRI 显示文摘	Bingel U Quante M Knab R	2002	Pain2002，99，12：	1
6	Magnetic susceptibility mapping of roadside pollution 显示文摘	HOFFMAN V KNAB M APPEL E	1999	Journal of Geochemical Exploration1999，66，：	1
7	Magnetic susceptibility mapping of roadside pollution显示文摘	HOFFMANN V KNAB M A	1999	Journal of Geochemical Exploration1999，66，：	1
8	Magnetic suscepbility mapping of roadside pollution显示文摘	HOFFMANN V KNAB M APPEL E	1999	Journal of Geochemical Exploration1999，66，：	1
9	Magnetic susceptibility mapping of roadside pollution显示文摘	HOFFMANN V KNAB M APPEL E	1999	Journal of geochemical Exploration1999，66，12：	1
10	Single trial fMRI reveals significant contralateral bias in responses to laser pain within thalamus and somatosensory cortices 显示文摘	Bingel U Quante M Knab R	2003	Neuroimage2003，18，3：	1
11	Magnetic susceptibility mapping of roadside pollution显示文摘	HOFFMANN V KNAB M APPEL E	1999	Journal of Geochemistry1999，66，12：	1
12	Close relation of endothelial function in the human coronary and peripheral circulations 显示文摘	Anderson T J Uehata A Gerhard M D Meredith I T Knab S Delagrange D	1995	J Am Coll Car- diol1995，26，：	1
13	Subcortical structures involved in pain processing:evidence from single 2 trial f MRI显示文摘	Bingel U Quante M Knab R	2002	Pain2002，99，12：	1
14	Magnetic susceptibility mapping of roadside pollution显示文摘	Hoffmann V Knab M Appel E	1999	Journal of Geochemical Exploration1999，66，：	1
15	Magnetic susceptibility mapping of roadside pollution显示文摘	Hoffmann V Knab M Appel E	1999	Journal of Geochemical Exploration1999，66，：	1
16	Magnetic susceptiility mapping of roadside pollution显示文摘	HOFFMANN V KNAB M APPEL E	1999	Journal of Geochemical Exploration1999，66，：	1
17	Magnetic susceptibility mapping of roadside pollution显示文摘	Hoffmann V Knab M Appel E	1999	journal of Geochemical Exploration1999，66，：	1
18	Magnetic susceptibility map-ping of roadside pollution显示文摘	HOFFMANN V KNAB M APPEL E	1999	Journal of Geochemical Exploration1999，66，：	1
19	Increased activity of factor VIII coagulant associated with venous ulcer in a patient with Klinefelter's syndrome 显示文摘	Dissemond J Knab J Lehnen M	2005	J Eur Acad Dermatol Venereol2005，19，2：	1
20	Magnetic susceptibility map-ping of roadside pollution 显示文摘	Hoffmann V Knab M Appel E	1999	Journal of Geochemical Explo-ration1999，66，1：	1

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