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| 1 | 微小RNA-1和微小RNA-29b对急性心肌梗死后不良心室重塑的诊断和预后价值显示文摘已知微小RNA(microRNAs,miRs)在急性心肌梗死(acute myocardial infarction,AMI)临床前期模型中可发挥纤维化和抗纤维化作用。为了评估miR-1,miR-21,miR-29b和miR-92a能否作为患者发生AMI后不良心室重塑(adverse ventricular remodeling,AVR)的循环生物标志物, | 刘莉 叶鹏 Grabmaier U Clauss S Gross L Klier I Franz WM Steinbeck G Wakili R Theiss HD Brenner C | 2017 | 中华高血压杂志2017，25，7： | 17 |
| 2 | Bacteriolytic therapy of experimental pancreatic carcinoma显示文摘AIM:To investigate the effectiveness of Clostridium novyi(C.novyi)-NT spores for the treatment of established subcutaneous pancreatic tumor in the syngeneic,immunocompetent Panc02/C57Bl/6 model. METHODS:C.novyi-NT spores were applied intravenously to animals carrying established pancreatic tumors of three different sizes.Systemic immune responses in peripheral blood and spleen were examined by flow cytometry.Supplementary,cytotoxic activity of lymphocytes against syngeneic tumor targets was analyzed. RESULTS:Application of spores identified,that(1) small tumors(<150 mm 3 )were completely unaffected (n=10);(2)very large tumors(>450 mm3)responded with substantial necrosis followed by shrinkage and significant lethality most likely due to tumor lysis syndrome (n=6);and(3)an optimal treatment window exists for tumors of approximately 250 mm 3 (n=21).In this latter group,all tumor-bearing animals had complete tu-mor regression and remained free of tumor recurrence. In subsequent tumor rechallenge experiments a significant delay in tumor growth compared to the initial tumor cell inoculation was observed(tumor volume at day 28:197.8±87.3 mm 3 vs 500.1±50.9 mm3,P<0.05). These effects were accompanied by systemic activation of immune response mechanisms predominantly mediated by the innate arm of the immune system. CONCLUSION:The observed complete tumor regression is encouraging and shows that immunotherapy with C.novyi-NT is an interesting strategy for the treatment of pancreatic carcinomas of defined sizes. | Claudia Maletzki Michael Gock Ulrike Klier Ernst Klar Michael Linnebacher | 2010 | World Journal of Gastroenterology2010，16，28： | 3 |
| 3 | Minor depressive di sorder in the context of miscarriage显示文摘 | Klier C Geiler P Neugebauer R | 2000 | J Affect Disord2000，59，10： | 1 |
| 4 | Adiponectin gene expression and secretion is inhibited by interleuidn-6 in 3T3-L1 adipocytes显示文摘 | Fasshauer M Kraliach S Klier M | 2003 | Biochem Biophys Res Commun2003，301，4： | 1 |
| 5 | Equilibrium swelling of poly ( methacrylie acid-g-ethylene glycol ) hydrogels : Effect of swelling medium and synthesis conditions 显示文摘 | Mathur A M Hammonds K F Klier J | 1998 | Journal of Controlled Release1998，54，2： | 1 |
| 6 | Self-associating networks of poly(methacry1ic acid-g-ethylene glycol)显示文摘 | Klier J Scranton A B Peppas N A | 1990 | Macromolecules1990，23，： | 1 |
| 7 | Chemokine-in duced secretion of gelatinase B in primary human mono- cytes显示文摘 | Klier CM Nelson EL Cohen CD | 2001 | Biol Chem2001，382，9： | 1 |
| 8 | The role of estrogen and proges-terone in depression after birth显示文摘 | KLIER C M MUZIK M | 2007 | J Psychiatr Res2007，41，34： | 1 |
| 9 | Location Trends of Large Company Headquarters during the 1990s显示文摘 | Klier T Testa W | 2002 | Economic Perspectives2002，，2： | 1 |
| 10 | Amyloid beta peptide induced necrosis rather than apoptosis显示文摘 | Behl C Davis J B Klier F G Schubert D | 1994 | Brain Res1994，645，12： | 1 |
| 11 | Sulfonic acid-functionalized meso- porous silica: synthesis, characterization, and catalytic reaction of alcohol coupling to ethers 显示文摘 | Shen J Herman R G Klier K | 2002 | Journal of Physical Chemistry B2002，106，39： | 1 |
| 12 | Equilibrium swelling of poly(methacrylic acid-g-ethylene glycol) hydrogels显示文摘 | Mathur A M Hammonds K F Klier J | 1998 | J Controlled Release1998，54，： | 1 |
| 13 | Higher alcohol and oxygenate synthesis over Cs/Cu/ZnO/M2 03 (M: A1, Cr) catalysts显示文摘 | NUNAN J G HERMAN R G KLIER K | 1989 | Journal of Catalysis1989，116，1： | 1 |
| 14 | Amyloid β peptide induces necrosis rather than apoptosis 显示文摘 | Davis JB Klier FG | 1994 | Brain Res1994，645，12： | 1 |
| 15 | Adiponectin gene expression and secretion is inhibited by interleukin - 6 in 3T3 - L1 adipocytes 显示文摘 | Fasshauer M Kralisch S Klier M | 2003 | Biochem Biophys Res Commun2003，301，4： | 1 |
| 16 | Methonal synthesis显示文摘 | Klier K | 1982 | Advances in Catalysis1982，31，： | 1 |
| 17 | Higher alcohol and oxygenate synthesis over cesium-doped Cu/ZnO catalysts显示文摘 | NUNAN J G BOGDAN C E KLIER K | 1989 | Journal of Catalysis1989，116，1： | 1 |
| 18 | Location trends of large company headquarters during the 1990s显示文摘 | Testa | 2002 | Economic Perspectives2002，，2： | 1 |
| 19 | Chemokine and chemokine receptor expression in novel human mesangial cell line显示文摘 | Banas B Luckow B Moller M Klier C Nelson PJ Schadde E | 1999 | J Am Soc Nephrol1999，10，11： | 1 |
| 20 | The changing relationship between headquarters and cities显示文摘 | Klier Ono | 2005 | Chicago Fed Letter2005，，3： | 1 |
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