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| 1 | Chromium does not belong in the diabetes treatment arsenal: Current evidence and future perspectives显示文摘Chromium is considered to have positive effects on insulin sensitivity and is marketed as an adjunctive therapy for inducing glucose tolerance in cases of insulin resistance('the glucose tolerance factor'). Case reports on patients who received prolonged parenteral nutrition indeed showed that the absence of trivalent chromium caused insulin resistance and diabetes. However, whether patients with type 2 diabetes can develop a clinically relevant chromium deficiency is unclear. This review summarizes the available evidence regarding the potential effectiveness of chromium supplementation on glycemic control(Hemoglobin A1c levels) in patients with type 2 diabetes. No studies investigating the longterm safety of chromium in humans were found. All clinical trials that have been performed had a relative short follow-up period. None of the trials investigated whether the patients had risk factors for chromium deficiency.The evidence from randomized trials in patients with type 2 diabetes demonstrated that chromium supplementation does not effectively improve glycemic control. The meta-analyses showed that chromium supplementation did not improve fasting plasma glucose levels. Moreover, there were no clinically relevant chromium effects on body weight in individuals with or without diabetes. Future studies should focus on reliable methods to estimate chromium status to identify patients at risk for pathological alterations in their metabolism associated with chromium deficiency. Given the present data, there is no evidence that supports advising patients with type 2 diabetes to take chromium supplements. | Gijs WD Landman Henk JG Bilo Sebastiaan T Houweling Nanne Kleefstra | 2014 | World Journal of Diabetes2014，5，2： | 3 |
| 2 | Device-guided breathing exercises for the treatment of hypertension: An overview显示文摘The American Heart Association considers device-guided breathing as a reasonable treatment modality in their statement on non-pharmacological options for lowering blood pressure. This review discusses all randomized controlled trials that have investigated the effects of device-guided breathing on blood pressure in patients with hypertension. Thirteen studies were included in this review. In total, 627 patients were in-cluded, of which 365 patients were allocated to device-guided breathing. Only 6 studies used acceptable control groups: listening to music, meditative relaxa-tion exercises, or a sham-device. Two sponsored trials showed beneficial effects of device-guided breathing, both used listening to music as a control group. The remaining 4 studies, which had no employees of the manufacturer listed as co-author, observed no benefi-cial effects on blood pressure. There is only 1 study that used a sham device as a control group. All other studies were to some extend methodologically flawed. Based on the studies with an acceptable methodologi-cal quality, there is no clear evidence supporting a short-term beneficial effect on blood pressure by using device-guided breathing. | Kornelis JJ van Hateren Gijs WD Landman Susan JJ Logtenberg Henk JG Bilo Nanne Kleefstra | 2014 | World Journal of Cardiology2014，6，5： | 2 |
| 3 | Metformin associated with lower cancer mortality in type 2 diabetes:ZODIAC-16显示文摘 | Landman GW Kleefstra N van Hateren KJ | 2010 | Diabetes Care2010，33，2： | 1 |
| 4 | Chromium treatment has no effect in patients with poorly controlled,insulin-treated type 2 diabetes in an obese Western population:a randomized,double-blind,placebo-controlled trial显示文摘 | Kleefstra N Houweling ST Jansman FG | 2006 | Diabetes Care2006，29，： | 1 |
| 5 | Chromium treatment has no effect in patients with type 2 diabetes in a Western population:a randomized,double-blind,placebo-controlled trial显示文摘 | Kleefstra N Houweling ST Bakker SJ | 2007 | Diabetes Care2007，30，： | 1 |
| 6 | Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16 显示文摘 | Landman GW Kleefstra N van Hateren KJ | | Diabetes Care0，33，2： | 1 |
| 7 | Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus显示文摘 | Kleefstra N Houweling ST Groenier KH | 2010 | Metabolism2010，59，11： | 1 |
| 8 | Diagnosis of diabetes mellitus:limited use for portable blood-glucose measuring devices显示文摘 | Houweling ST Kleefstra N van Ballegooie E | 2005 | Ned Tijdschr Geneeskd2005，149，13： | 1 |
| 9 | Lower blood pres- sure associated with higher mortality in elderly diabetic patients (ZO- DIAC-12)显示文摘 | van Hateren K J Landman GW Kleefstra N | 2010 | Age2010，39，5： | 1 |
| 10 | Effect of device-guided breathing exercises on blood pressure in patients with hypertension: a randomized controlled trial显示文摘 | Altena MR Kleefstra N Logtenberg SJ | 2009 | Blood Press2009，18，5： | 1 |
| 11 | Metformin associated with lower cancer mortality in type 2 diabetes:ZODIAC - 16显示文摘 | Landman GWD Kleefstra N Van Hateren KJJ | 2010 | Diabetes Care2010，33，： | 1 |
| 12 | A core questionnaire for the assess-ment of patient satisfaction in academic hospitalsin The Netherlands : development and first re-sults in a nationwide study 显示文摘 | Kleefstra SM Kool RB VeldkampCM | 2010 | Quality & Safetyin Health Care2010，19，5： | 1 |
| 13 | Metformin associated with lower cancer mortality in type 2 diabetesZODIAC-16显示文摘 | Landman GW Kleefstra N van Hateren KJ | | 0，，： | 1 |
| 14 | Met-formin associated with lower cancer mortality in type 2 diabetes:ZODIAC-16显示文摘 | Landman GW Kleefstra N van Hateren KJ | | 0，，02： | 1 |
| 15 | Glycaemic control and the risk of mortality in elderly type 2 diabetic patients ( ZODIAC -20) 显示文摘 | van Hateren K J Landman GW Kleefstra N | 2011 | Int J Clin Pract2011，65，4： | 1 |
| 16 | Diabetes specialist nurse as main care provider for patients with type 2 diabetes显示文摘 | Houweling ST Kleefstra N Hateren KJJ | 2009 | The Netherlands Journal of Medicine2009，67，7： | 1 |
| 17 | Diabetes specialist nurse as main care provider for patients with type 2 diabetes显示文摘 | Houweling ST Kleefstra N van Hateren KJ | 2009 | Neth J Med2009，67，7： | 1 |
| 18 | Alpha lipoic acid: a new treatment for neuropathic pain in pa?tients with diabetes显示文摘 | MUNHOUT G S ALKHALAF A KLEEFSTRA N | 2010 | NethJ Med2010，68，4： | 1 |
| 19 | Health-related quality of life and mortality in a general and elderly population of patients with type 2 diabetes(ZODIAC18)显示文摘 | Landman GW van Hateren KJ Kleefstra N | 2010 | Diabetes Care2010，，33： | 1 |
| 20 | Prediction of mortality in type 2 diabetes from health-related quality of life (ZODIAC-4) 显示文摘 | Kleefstra N Landman GW Houweling ST | 2008 | Diabetes Care2008，31，5： | 1 |
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