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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 3 | Effect of monomeric and polymeric co-solutes on cetyltrimethylammonium bromide wormlike micelles:Rheology,Cryo-TEM and Small-angle neutron scattering显示文摘 | Kelly R.Francisco Marcelo A.da Silva Edvaldo Sabadini G(a)ran Karlsson Cécile A.Dreiss | | 0，，： | 1 |
| 4 | Perception of environmental obstacles to commuting physical activity in Brazilian elderly显示文摘 | Maruí W. Corseuil Ione Jayce C. Schneider Diego A. Santos Silva Filipe F. Costa Kelly S. Silva Lucélia J. Borges Eleonora d’Orsi | 2011 | Preventive Medicine2011，，4： | 1 |
| 5 | Carbon and nitrogen i- otopic compositions of particulate organic matter in four arge river systems across the United States 显示文摘 | ~endall C Silva S R Kelly V J | 2001 | Hydro- ogical Processes2001，15，7： | 1 |
| 6 | Neurobehavioral and genotoxic parameters of antipsychotic agent aripiprazole in mice显示文摘目的: Aripiprazole 是一个抑制精神的代理人对待精神分裂症,它通过多巴胺 D 2 扮演部分 agonism,血清素 5-HT 1A 部分 agonism 和 5-HT 2A 对抗。这研究被设计在 lipoperoxidation 上评估 neurobehavioral 效果和代理人,以及它的效果的 genotoxic/mutagenic 活动。 | Jaqueline Nascimento PICADA Bruna de Jesus Neto DOS SANTOS Franciele CELSO Jessica Dias MONTEIRO Kelly Morais DA ROSA Leandro Rosa CAMACHO Luciana Rodrigues VIEIRA Tars Madelon FREITAS Tatiana Grasiela DA SILVA Viviane Minuzzo PONTES Patricia PEREIRA | 2011 | Acta Pharmacologica Sinica2011，32，10： | 1 |
| 7 | Carbon and nitrogen isotopic compositions of Particulate organic matter in four large river systems across the United States 显示文摘 | Kendall C Silva S R Kelly V J | 2001 | Hydrological Processes2001，15，： | 1 |
| 8 | Novel insights on interactions between folate and lipid metabolism显示文摘 | Robin P. Silva Karen B. Kelly Ala Al Rajabi René L. Jacobs | 2014 | BioFactors2014，，3： | 1 |
| 9 | Carbon and nitrogen isotopic compositions of particulate organic matter in four large river systems across the United States显示文摘 | ENDALL C SILVA S R KELLY V J | 2001 | Hydrol Proc2001，15，： | 1 |
| 10 | Effect of monomeric and polymeric cosolutes on cetvltrimethyammonium bromide wormlike micelles:Rheology,Cryo-TEM and Small-angle neutron scattering显示文摘 | Kelly R Francisco Marcelo A da Silva Edvaldo Sabadini | 2010 | Journal of Colloid and Interface Science2010，345，： | 1 |
| 11 | Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice显示文摘Alzheimer’s disease is a progressive brain disorder and complex mechanisms are involved in the physiopathology of Alzheimer’s disease.However,there is data suggesting that inflammation plays a role in its development and progression.Indeed,some non-steroidal antiinflammatory drugs,such as meloxicam,which act by inhibiting cyclooxygenase-2 have been used as neuroprotective agents in different neurodegenerative disease models.The purpose of this study was to investigate the effects of co-nanoencapsulated curcumin and meloxicam in lipid core nanocapsules(LCN)on cognitive impairment induced by amyloid-beta peptide injection in mice.LCN were prepared by the nanoprecipitation method.Male Swiss mice received a single intracerebroventricular injection of amyloid-beta peptide aggregates(fragment 25–35,3 nmol/3μL)or vehicle and were subsequently treated with curcumin-loaded LCN(10 mg/kg)or meloxicam-loaded LCN(5 mg/kg)or meloxicam+curcumin-co-loaded LCN(5 and 10 mg/kg,respectively).Treatments were given on alternate days for 12 days(i.e.,six doses,once every 48 hours,by intragastric gavage).Our data showed that amyloid-beta peptide infusion caused long-term memory deficits in the inhibitory avoidance and object recognition tests in mice.In the inhibitory avoidance test,both meloxicam and curcumin formulations(oil or co-loaded LCN)improved amyloid-beta-induced memory impairment in mice.However,only meloxicam and curcumin-co-loaded LCN attenuated non-aversive memory impairment in the object recognition test.Moreover,the beneficial effects of meloxicam and curcuminco-loaded LCN could be explained by the anti-inflammatory properties of these drugs through cortical cyclooxygenase-2 downregulation.Our study suggests that the neuroprotective potential of meloxicam and curcumin co-nanoencapsulation is associated with cortical cyclooxygenase-2 modulation.This study was approved by the Committee on Care and Use of Experimental Animal Resources,the Federal University of Pampa,Brazil(approval No.02-2015)on April 16,2015. | Maria Eduarda Ziani Gutierrez Anne Suély Pinto Savall Edina da Luz Abreu Kelly Ayumi Nakama Renata Bem Dos Santos Marina Costa Monteiro Guedes Daiana SilvaÁvila Cristiane Luchese Sandra Elisa Haas Caroline Brandão Quines Simone Pinton | 2021 | Neural Regeneration Research2021，16，4： | 1 |
| 12 | Movement behaviors and their association with depressive symptoms in Brazilian adolescents:A cross-sectional study显示文摘Background:Physical activity,sleep,and sedentary behaviors compose 24-h movement behaviors and have been independently associated with depressive symptoms.However,it is not clear whether it is the movement behavior itself or other contextual factors that are related to depressive symptoms.The objective of the present study was to examine the associations between self-reported and accelerometer-measured movement behaviors and depressive symptoms in adolescents.Methods:Cross-sectional data from 610 adolescents(14-18 years old)were used.Adolescents answered questions from the Center for Epidemiological Studies Depression scale and reported time spent watching videos,playing videogames,using social media,time spent in various physical activities,and daytime sleepiness.Wrist-worn accelerometers were used to measure sleep duration,sleep efficiency,sedentary time,and physical activity.Mixed-effects logistic regressions were used.Results:Almost half of the adolescents(48%)were classified as being at high risk for depression(score≥20).No significant associations were found between depressive symptoms and accelerometer-measured movement behaviors,self-reported non-sport physical activity,watching videos,and playing videogames.However,higher levels of self-reported total physical activity(odd ratio(OR)=0.92,95%confidence interval(95%CI):0.86-0.98)and volume of sports(OR=0.88,95%CI:0.79-0.97),in minutes,were associated with a lower risk of depression,while using social media for either 2.0-3.9 h/day(OR=1.77,95%CI:1.58-2.70)or>3.9 h/day(OR=1.67,95%CI:1.10-2.54),as well as higher levels of daytime sleepiness(OR=1.17,95%CI:1.12-1.22),were associated with a higher risk of depression.Conclusion:What adolescents do when they are active or sedentary may be more important than the time spent in the movement behaviors because it relates to depressive symptoms.Targeting daytime sleepiness,promoting sports,and limiting social media use may benefit adolescents. | Bruno Goncalves Galdino da Costa Jean-Philippe Chaput Marcus Vinicius Veber Lopes Luis Eduardo Argenta Malheiros Kelly Samara Silva | 2022 | Journal of Sport and Health Science2022，11，2： | 1 |
| 13 | Islet Neogenesis Associated Protein (INGAP) modulates gene expression in cultured neonatal rat islets显示文摘 | Helena Barbosa Silvana Bordin Luiz Stoppiglia Kelly Silva Maria Borelli Héctor Del Zotto Juan Gagliardino Antonio Boschero | 2006 | ScienceDirect2006，136，： | 1 |
| 14 | Unidirectional Rotary Motion in a Molecular System显示文摘 | KELLY T R DE SILVA H SILVA R A | 1999 | Nature1999，401，： | 1 |
| 15 | Carbon and nitrogen isotopic compositions of particulate organic matter in four large river systems across the United States显示文摘 | Kendall C Silva S R Kelly V J | 2001 | Hydrological Processes2001，15，7： | 1 |
| 16 | Carbon and nitrogen isotopic compositions of particulate organic matter in four large river systems across the United States 显示文摘 | Kendall C Silva S R Kelly V J | 2001 | Hydrological Processes2001，15，7： | 1 |
| 17 | Olive oil and lemon salad dressing microencapsulated by freeze-drying显示文摘 | KELLY A SILVA MARIA ALICE Z COELHO VERONICA M A CALADO | 2013 | Food Science and Technology2013，50，2： | 1 |
| 18 | Creatine reduces hepatic TG accumulation in hepatocytes by stimulating fatty acid oxidation显示文摘 | Robin P. da Silva Karen B. Kelly Kelly-Ann Leonard René L. Jacobs | 2014 | BBA - Molecular and Cell Biology of Lipids2014，，11： | 1 |
| 19 | Unidirectional ro- tary motion in a molecular system 显示文摘 | Kelly T R Silva H De Silva R A | 1999 | Nature1999，401，150： | 1 |
| 20 | Inclusion complexes of pyrimethamine in 2-hydroxypropyl-β-cyclodextrin: characterization, phase solubility and molecular modelling 显示文摘 | MARCIA VALERIA GASPAR DE ARAuJO ELZE KELLY BARBOSA VIEIRA GILDERMAN SILVA LAZARO | 2007 | Bioorganic & Medicinal Chemistry2007，15，17： | 1 |
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