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| 1 | 在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。 | McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 15 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 4 | Characterization Study of Diamond and Diamond-like Carbon显示文摘 | Dowling D P Ahern M J Kelly T C | 1992 | Surface and Coating Technology1992，53，： | 2 |
| 5 | Therapeutic Efficacy by Recombinant Human Granulocyte/Monocyte-Colony Stimulating Factor on Mucositis Occurring in Patients with Oral and Oropharynx Tumors Treated with Curative Radiotherapy显示文摘 | Masucci G Broman P Kelly C | | 0，，03： | 1 |
| 6 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 7 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 8 | The roles of gender,the menopause and hormone replacement on cardiovascular function显示文摘 | HAYWARD C S KELLY R P COLLONS P | 2000 | Cardiovasc Res2000，46，1： | 1 |
| 9 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 10 | Early experience with endoscopic carpal tunnel release 显示文摘 | Kelly C P Pulistetti D Jamieson A M | 1994 | J Hand surg Br1994，19，1： | 1 |
| 11 | Prolactin (PRL)and its receptor:actions,signal transduetion pathways and henotypes observed in PRL receptor knockout mice显示文摘 | Gomn V EderyM Binaa N Kelly P A | 1998 | Endocrine Reviews1998，19，3： | 1 |
| 12 | Selective reverse-reactivation of normal faults, and deformation around reverse-reactivated faults in the Mesozoic of the Somerset coast 显示文摘 | Kelly P G Peacock D C P Sanderson D J | 1999 | Journal of Structural Geology1999，21，： | 1 |
| 13 | Vitamin D status and cytokine levels in patients with Crohn′s disease显示文摘 | Kelly P Suibhne TN O′Morain C | 2011 | Int J Vitam Nutr Res2011，81，4： | 1 |
| 14 | Mammary gland development and the prolactin receptor显示文摘 | BINART N ORMANDY C J KELLY P A | 2000 | Adv Exp Med Biol2000，480，： | 1 |
| 15 | Long-term outcome related to epidermal growth factor receptor status in bladder cancer 显示文摘 | Mellon K Wright C Kelly P | 1995 | J Urol1995，153，3： | 1 |
| 16 | Characterization study of diamond and diamond-like carbon显示文摘 | Dowling D P Ahern M J Kelly T C | 1992 | Surface and Coatings Technology1992，53，： | 1 |
| 17 | The coupling of the finite element method and boundary solution procedures显示文摘 | KELLY D W BETTESS P | 1977 | International Journal of Numerical Methods in Engineering1977，11，6： | 1 |
| 18 | Effect of Elevated Temperature Exposure on Cast Gamma Titanium Aluminide (Ti-48Al-2Cr-2Nb) 显示文摘 | Kelly T J Austin C M Fink P J | 1994 | Scripta Metallurgica et Materialia1994，30，9： | 1 |
| 19 | Transformation toughening in zirconia-containing ceramics显示文摘 | HANNINK H J KELLY P M MUDDLE B C | 2000 | Journal of the American Ceramic Society2000，83，3： | 1 |
| 20 | Type interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (Pristane)显示文摘 | Nacionales D C Kelly K M Lee P Y | 2006 | AM J Pathol2006，168，4： | 1 |
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