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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 3 | Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?显示文摘AIM To investigate the correlation of iodine concentration(IC) generated by spectral computed tomography(CT) with micro-vessel density(MVD) and vascular endothelial growth factor(VEGF) expression in patients with advanced gastric carcinoma(GC).METHODS Thirty-four advanced GC patients underwent abdominal enhanced CT in the gemstone spectral imaging mode. The IC of the primary lesion in the arterial phase(AP) and venous phase(VP) were measured, and were then normalized against that in the aorta to provide the normalized IC(nI C). MVD and VEGF were detected by immunohistochemical assays, using CD34 and VEGF-A antibodies, respectively. Correlations of nI C with MVD, VEGF, and clinical-pathological features were analyzed.RESULTS Both nI Cs correlated linearly with MVD and were higher in the primary lesion site than in the normal control site, but were not correlated with VEGF expression. After stratification by clinical-pathological subtypes, nI C-AP showed a statistically significant correlation with MVD, particularly in the group with tumors at stage T4, without nodular involvement, of a mixed Lauren type, where the tumor was located at the antrum site, and occurred in female individuals. nI C-VP showed a positive correlation with MVD in the group with the tumor at stage T4 and above, had nodular involvement, was poorly differentiated, was located at the pylorus site, of a mixed and diffused Lauren subtype, and occurred in male individuals. nI C-AP and nI C-VP showed significant differences in terms of histological differentiation and Lauren subtype.CONCLUSION The IC detected by spectral CT correlated with the MVD. n IC-AP and n IC-VP can reflect angiogenesis in different pathological subgroups of advanced GC. | Xiao-Hua Chen Ke Ren Pan Liang Yaru Chai Kui-Sheng Chen Jian-Bo Gao | 2017 | World Journal of Gastroenterology2017，23，9： | 47 |
| 4 | Systematic review and meta-analysis of laparoscopy-assisted and open total gastrectomy for gastric cancer显示文摘AIM:To evaluate the safety and efficacy of laparoscopy-assisted total gastrectomy(LATG)and open total gastrectomy(OTG)for gastric cancer.METHODS:A comprehensive search of PubMed,Cochrane Library,Web of Science and BIOSIS Previews was performed to identify studies that compared LATG and OTG.The following factors were checked:operating time,blood loss,harvested lymph nodes,flatus time,hospital stay,mortality and morbidity.Data synthesis and statistical analysis were carried out using RevMan 5.1 software.RESULTS:Nine studies with 1221 participants were included(436 LATG and 785 OTG).Compared to OTG,LATG involved a longer operating time[weighted mean difference(WMD)=57.68 min,95%CI:30.48-84.88;P<0.001];less blood loss[standard mean difference(SMD)=-1.71;95%CI:-2.48--0.49;P<0.001];earlier time to flatus(WMD=-0.76 d;95%CI:-1.22--0.30;P<0.001);shorter hospital stay(WMD=-2.67d;95%CI:-3.96--1.38,P<0.001);and a decrease in medical complications(RR=0.41,95%CI:0.19-0.90,P=0.03).The number of harvested lymph nodes,mortality,surgical complications,cancer recurrence rate and long-term survival rate of patients undergoing LATG were similar to those in patients undergoing OTG.CONCLUSION:Despite a longer operation,LATG can be performed safely in experienced surgical centers with a shorter hospital stay and fewer complications than open surgery. | Ke Chen Xiao-Wu Xu Ren-Chao Zhang Yu Pan Di Wu Yi-Ping Mou | 2013 | World Journal of Gastroenterology2013，19，32： | 23 |
| 5 | New technological partition for “three zones” spontaneous coal combustion in goaf显示文摘On detailed analysis basis of spontaneous coal combustion for the three zones in mine goaf,we use O2 and CO concentrations to divide the three zones of the coal combustion.Through our experiment,we selected a typical working face and focused on the changes in gas concentrations.In order to overcome establishment limitations of actual layout location and underground conditions in a mine goaf,we based our observations on the three zones,combined them with numerical simulation,described the distribution and the changes in O2 and CO concentrations during the coal spontaneous combustion in the goaf,which provided us with an understanding of the distribution of coal spontaneous combustion in the three zones in the form of maps.Essentially,our study summarizes the changes of O2and CO concentrations in the entire goaf and shows them to be in agreement with our observations at the scene.The study shows that it is feasible to divide the three zones,given our comprehensive targets of O2,CO and our numerical simulation.This method avoids the limitation of dividing the three zones with a single target and the likely errors of observations at the scene.In addition,the method offers a basis for optimizing measures of fre-fghting with important and practical effects. | Pan Rongkun Cheng Yuanping Yu Minggao Lu Chang Yang Ke | 2013 | International Journal of Mining Science and Technology2013，23，4： | 20 |
| 6 | Totally laparoscopic gastrectomy for gastric cancer: A systematic review and meta-analysis of outcomes compared with open surgery显示文摘AIM:To systematically review the surgical outcomes of totally laparoscopic gastrectomy(TLG)vs open gastrectomy(OG)for gastric cancer.METHODS:A systematic search of PubMed,Embase,Cochrane Library,and Web of Science was conducted.All original studies comparing TLG with OG were included for critical appraisal.Data synthesis and statistical analysis were carried out using RevMan 5.1 software.RESULTS:One RCT and 13 observational studies involving 1532 patients were included(721 TLG and811 OG).TLG was associated with longer operation time[weighted mean difference(WMD)=58.04min,95%CI:37.77-78.32,P<0.001],less blood loss[WMD=-167.57 min,95%CI:-208.79-(-126.34),P<0.001],shorter hospital stay[WMD=-3.75 d,95%CI:-4.88-(-2.63),P<0.001]and fewer postoperative complications(RR=0.71,95%CI:0.58-0.86,P<0.001).The number of harvested lymph nodes,surgical margin,mortality and cancer recurrence rate were similar between the two groups.CONCLUSION:TLG may be a technically safe,feasible and favorable approach in terms of better cosmesis,less blood loss and faster recovery compared with OG. | Ke Chen Yu Pan Jia-Qin Cai Xiao-Wu Xu Di Wu Yi-Ping Mou | 2014 | World Journal of Gastroenterology2014，20，42： | 19 |
| 7 | Curcumin inhibits hepatitis B virus infection by downregulating ccc DNA-bound histone acetylation显示文摘AIM To investigate the potential effect of curcumin on hepatitis B virus(HBV) covalently closed circular DNA(ccc DNA) and the underlying mechanism.METHODS A Hep G2.2.15 cell line stably transfected with HBV was treated with curcumin, and HBV surface antigen(HBs Ag) and e antigen(HBe Ag) expression levels were assessed by ELISA. Intracellular HBV DNA replication intermediates and ccc DNA were detected by Southern blot and real-time PCR, respectively. The acetylation levels of histones H3 and H4 were measured by Western blot. H3/H4-bound ccc DNA was detected by chromatin immunoprecipitation(Ch IP) assays. The deacetylase inhibitors trichostatin A and sodium butyrate were used to study the mechanism of action for curcumin. Additionally, short interfering RNAs(si RNAs) targeting HBV were tested along with curcumin.RESULTS Curcumin treatment led to time-and dose-dependent reductions in HBs Ag and HBe Ag expression and significant reductions in intracellular HBV DNA replication intermediates and HBV ccc DNA. After treatment with 20 μmol/L curcumin for 2 d, HBs Ag and ccc DNA levels in Hep G2.2.15 cells were reduced by up to 57.7%(P < 0.01) and 75.5%(P < 0.01), respectively, compared with levels in non-treated cells. Meanwhile, time-and dose-dependent reductions in the histone H3 acetylation levels were also detected upon treatment with curcumin, accompanied by reductions in H3-and H4-bound ccc DNA. Furthermore, the deacetylase inhibitors trichostatin A and sodium butyrate could block the effects of curcumin. Additionally, transfection of si RNAs targeting HBV enhanced the inhibitory effects of curcumin.CONCLUSION Curcumin inhibits HBV gene replication via downregulation of ccc DNA-bound histone acetylation and has the potential to be developed as a ccc DNA-targeting antiviral agent for hepatitis B. | Zhi-Qiang Wei Yong-Hong Zhang Chang-Zheng Ke Hong-Xia Chen Pan Ren Yu-Lin He Pei Hu De-Qiang Ma Jie Luo Zhong-Ji Meng | 2017 | World Journal of Gastroenterology2017，23，34： | 18 |
| 8 | Analysis of CD8+ Treg cells in patients with ovarian cancer: a possible mechanism for immune impairment显示文摘 | Shuping Zhang | 2015 | Cellular & Molecular Immunology2015，12，5： | 17 |
| 9 | Case-matched comparison of laparoscopy-assisted and open distal gastrectomy for gastric cancer显示文摘AIM: To compare shortand long-term outcomes of laparoscopy-assisted and open distal gastrectomy for gastric cancer. METHODS: A retrospective study was performed by comparing the outcomes of 54 patients who underwent laparoscopy-assisted distal gastrectomy (LADG) with those of 54 patients who underwent open distal gastrectomy (ODG) between October 2004 and October 2007. The patients' demographic data (age and gender), date of surgery, extent of lymphadenectomy, and differentiation and tumor-node-metastasis stage of the tumor were examined. The operative time, intraoperative blood loss, postoperative recovery, complications, pathological findings, and follow-up data were compared between the two groups.RESULTS: The mean operative time was significantly longer in the LADG group than in the ODG group (259.3 ± 46.2 min vs 199.8 ± 40.85 min; P < 0.05), whereas intraoperative blood loss and postoperative complications were significantly lower (160.2 ± 85.9 mL vs 257.8 ± 151.0 mL; 13.0% vs 24.1%, respectively, P < 0.05). In addition, the time to first flatus, time to initiate oral intake, and postoperative hospital stay were significantly shorter in the LADG group than in the ODG group (3.9 ± 1.4 d vs 4.4 ± 1.5 d; 4.6 ± 1.2 d vs 5.6 ± 2.1 d; and 9.5 ± 2.7 d vs 11.1 ± 4.1 d, respectively; P < 0.05). There was no significant difference between the LADG group and ODG group with regard to the number of harvested lymph nodes. The median followup was 60 mo (range, 5-97 mo). The 1-, 3-, and 5-year disease-free survival rates were 94.3%, 90.2%, and 76.7%, respectively, in the LADG group and 89.5%, 84.7%, and 82.3%, respectively, in the ODG group. The 1-, 3-, and 5-year overall survival rates were 98.0%, 91.9%, and 81.1%, respectively, in the LADG group and 91.5%, 86.9%, and 82.1%, respectively, in the ODG group. There was no significant difference between the two groups with regard to the survival rate. CONCLUSION: LADG is suitable and minimally invasive for treating distal gastric cancer and can achieve similar long-term results to ODG. | Wei Wang Ke Chen Xiao-Wu Xu Yu Pan Yi-Ping Mou | 2013 | World Journal of Gastroenterology2013，19，23： | 15 |
| 10 | Intracorporeal esophagojejunostomy after totally laparoscopic total gastrectomy: A single-center 7-year experience显示文摘AIM: To assess the efficacy and safety of intracorporeal esophagojejunostomy in patients undergoing laparoscopic total gastrectomy(LTG) for gastric cancer.METHODS: A retrospective review of 81 consecutive patients who underwent LTG with the same surgical team between November 2007 and July 2014 was performed. Four types of intracorporeal esophagojejunostomy using staplers or hand-sewn suturing were performed after LTG. Data on clinicopatholgoical characteristics, occurrence of complications, postoperative recovery, anastomotic time, and operation time among the surgical groups were obtained through medical records.RESULTS: The average operation time was 288.7 min, the average anastomotic time was 54.3 min, and the average estimated blood loss was 82.7 m L. There were no cases of conversion to open surgery. The first flatus was observed around 3.7 d, while the liquid diet was started, on average, from 4.9 d. The average postoperative hospital stay was 10.1 d. Postoperative complications occurred in 14 patients, nearly 17.3%.However, there were no cases of postoperative death.CONCLUSION: LTG performed with intracorporeal esophagojejunostomy using laparoscopic staplers or hand-sewn suturing is feasible and safe. The surgical results were acceptable from the perspective of minimal invasiveness. | Ke Chen Yu Pan Jia-Qin Cai Xiao-Wu Xu Di Wu Jia-Fei Yan Rong-Gao Chen Yang He Yi-Ping Mou | 2016 | World Journal of Gastroenterology2016，22，12： | 14 |
| 11 | Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine显示文摘 | Zhao P Cao J Zhao LJ Ke JS Pan W Ren H Yu JG Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 12 |
| 12 | Comparison of Intracorporeal and Extracorporeal Esophagojejunostomy after Laparoscopic Total Gastrectomy for Gastric Cancer: A Meta-Analysis Based on Short-Term显示文摘 | XueoYong Zheng Yu Pan Ke Chen Jia-Qi Gao Xiu-Jun Cai | 2018 | Chinese Medical Journal2018，，6： | 12 |
| 13 | Niclosamide,an old antihelminthic agent,demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells显示文摘Niclosamide,an oral antihelminthic drug,has been used to treat tapeworm infection for about 50 years.Niclosamide is also used as a molluscicide for water treatment in schistosomiasis control programs.Recently,several groups have independently discovered that niclosamide is also active against cancer cells,but its precise mechanism of antitumor action is not fully understood.Evidence supports that niclosamide targets multiple signaling pathways (NF-κB,Wnt/β-catenin,Notch,ROS,mTORC1,and Stat3),most of which are closely involved with cancer stem cells.The exciting advances in elucidating the antitumor activity and the molecular targets of this drug will be discussed.A method for synthesizing a phosphate pro-drug of niclosamide is provided.Given its potential antitumor activity,clinical trials for niclosamide and its derivatives are warranted for cancer treatment. | Jing-Xuan Pan Ke Ding Cheng-Yan Wang | 2012 | Chinese Journal of Cancer2012，31，4： | 11 |
| 14 | Economic burden and its associated factors of hospitalized patients infected with A (H7N9) virus: a retrospective study in Eastern China, 2013–2014显示文摘Background:H7N9 continues to cause human infections and remains a pandemic concern.Understanding the economic impacts of this novel disease is important for making decisions on health resource allocation,including infectious disease prevention and control investment.However,there are limited data on such impacts.Methods:Hospitalized laboratory-confirmed H7N9 patients or their families in Jiangsu Province of China were interviewed.Patients’direct medical costs of hospitalization were derived from their hospital bills.A generalized linear model was employed to estimate the mean direct medical costs of patients with different characteristics.Results:The mean direct cost of hospitalization for H7N9 was estimated to be¥71060(95%CI,48180–104820),i.e.,US$10996(95%CI,7455–16220),and was¥12060(US$1861),¥136120(US$21001)and¥218610(US$33728)for those who had mild or severe symptoms or who died,respectively.The principal components of the total fees differed among patients with different disease severity,although medication fees were always the largest contributors.Disease severity,proportion of reimbursement and family member monthly average income were identified as the key factors that contributed to a patient’s direct medical cost of hospitalization.Conclusions:The direct medical costs of hospitalized patients with H7N9 are significant,and far surpass the annual per capita income of Jiangsu Province,China.The influencing factors identified should be taken into account when developing related health insurance policies and making health resource allocation.Trial registration:Not applicable.This is a survey study with no health care intervention implemented on human participants. | Xiang Huo Li-Ling Chen Lei Hong Lun-Hui Xiang Fen-Yang Tang Shan-Hui Chen Qiang Gao Cong Chen Qi-gang Dai Chuan-Wu Sun Ke Xu Wen-Jun Dai Xian Qi Chang-Cheng Li Hui-Yan Yu Yin Zhou Hao-Di Huang Xing-Yang Pan Chang-sha Xu Ming-Hao Zhou Chang-Jun Bao | 2016 | Infectious Diseases of Poverty2016，5，1： | 10 |
| 15 | Risk factors of rhegmatogenous retinal detachment associated with choroidal detachment in Chinese patients显示文摘AIM:To comprehensively analyze the risk factors of rhegmatogenous retinal detachment(RRD) associated with choroidal detachment(CD).METHODS:A total of 265 eyes of 265 consecutive cases of RRD were retrospectively analyzed.All patients had systemic and ophthalmologic examination.CD was diagnosed by indirect ophthalmoscopy,B-scan ultrasonography,and ultrasound biomicroscope(UBM).Each parameter was compared between patients of RRD and rhegmatogenous retinal detachment associated with choroidal detachment(RRDCD).Logistic regression analysis was used to determine the independent risk factors of CD.RESULTS:There were 52 eyes(19.62%) with CD.Pseudophakia was more commonly seen in RRDCD(21.15% vs 6.10%,P=0.002).Intraocular pressure(IOP)was lower(8.60±3.62 vs 12.96±3.55,P<0.001),bestcorrected visual acuity was worse[3.00(2.00 to 3.00) vs 1.92(1.22 to 3.00),P=0.001],and refractive error was more myopic[-4(-9 to -2) vs-2(-6 to 0),P =0.007]in RRDCD.Eyes with RRDCD had larger extent of retinal detachment(P=0.007).In RRDCD,34.62% of eyes presented with multiple holes(P=0.044) and 25.00% with macular holes(P=0.012),compared with 20.66% and 14.08% in RRD.High myopia(P=0.039),low IOP(P=0.017),and larger extent of retinal detachment(P<0.001) were significant and independent risk factors for developing CD.CONCLUSION:For CD in RRD,related factors include BCVA,IOP,lens status,refractive error,extent of retinal detachment,number of holes,and macular hole.Larger extent of retinal detachment,high myopia,and low IOP are significant and independent risk factors. | Yong-Hao Gu Gen-Jie Ke Lin Wang Qi-Hong Gu En-Liang Zhou Hong-Biao Pan Shi-Ying Wang | 2016 | International Journal of Ophthalmology(English edition)2016，9，7： | 10 |
| 16 | Enhanced aromatic selectivity by the sheet-like ZSM-5 in syngas conversion显示文摘Aromatics are important basic chemicals. However, direct conversion of syngas via the conventional Fischer-Tropsch synthesis produces little aromatics. We presented herein that a bifunctional composite of ZSM-5 in combination with Zn Cr Oxcatalyzes syngas conversion to aromatics. Particularly, ZSM-5 crystals with a sheet-like morphology can enhance significantly the aromatization activity. The lower length ratio of the b/a axes of the crystals, the more aromatics form but without influencing the selectivity of small molecules such as CH4 and C2–C4. Since the acid properties and the Al chemical environment were not altered while the morphology changed, the enhanced aromatic selectivity is likely attributed to the favored diffusion of aromatics in these sheet-like crystals. | Junhao Yang Ke Gong Dengyun Miao Feng Jiao Xiulian Pan Xiangju Meng Fengshou Xiao Xinhe Bao | 2019 | Journal of Energy Chemistry2019，28，8： | 10 |
| 17 | Antibodies against the C-terminal peptide of rabbit oviductin inhibit mouse early embryo development to pass 2-cell stage显示文摘A full-length rabbit oviductin cDNA(1909bp) was cloned. It consists of a 5’-UTR of 52bp, an open reading frame (ORF) of 1374bp and a 3’-UTR of 483bp and has more than 80% homology with that of other mammal oviductins. N-terminal peptide (NTP) (384 residues) and C-terminal peptide (CTP) (73 residues) of deduced protein precursor has about 80% and 50% identity with that of other mammals respectively. Fusion proteins GST-NTP 368(1R-368N)and GST-CTP73 (369F-441A) were expressed and purified. NH2-terminal of CTP sequencing reveals that the purified protein is consistent with the deduced one. In order to study the function of NTP and CTP the mouse anti-NTP and rabbit anti-CTP antisera were prepared. Tissue-specific (skeleton muscle, oviduct, uterus, ovary, liver, heart and brain) analysis indicated that rabbit oviductin was only found in oviduct. The conditioned medium derived from the rabbit oviduct mucosa epithelial cells has a function of overcoming the early embryonic development block of Kunming mous e cultured in vitro. Anti-CTP antiserum could totally inhibit the early embryo development at 2-cell stage cultured in the conditioned culture medium, but anti-NTP antiserum couldn’t. There was a positive relationship between the ratio of early embryos at development block and the dosage of anti-CTP antiserum added in the conditioned culture medium. These results suggest that oviductin has a function not only on fertilization, but also on the release of early embryonic development block, and the later function domain of rabbit oviductin may be situate in its C-terminal. | PAN YONG, ZHENG GU, JIN PING LUO, JUN Ru WANG, JIA KE TSO National Laboratory of Contraceptives and Devices Research, Shanghai Institute of Planned Parenthood Research, 21.40 Xietu Road, Shanghai 200032, China | 2002 | Cell Research2002，12，1： | 8 |
| 18 | Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction显示文摘 | Xiao-E Jia Ke Ma Tao Xu Lei Gao Shuang Wu Cong Fu Wenjuan Zhang Zhizhang Wang Kaiyu Liu Mei Dong Changbin Jing Chunguang Ren Zhiwei Dong Yi Chen Yi Jin Qiuhua Huang Xing Chang Min Deng Li Li Lingfei Luo Jun Zhu Yongjun Dang Hung-Chun Chang Leonard I Zon Yi Zhou Saijuan Chen Weijun Pan | 2015 | Cell Research2015，25，8： | 8 |
| 19 | Remarkably improved hydrogen storage properties of nanocrystalline TiO2-modified NaAlH4 and evolution of Ti- containing species during dehydrogenation/hydrogenation显示文摘增加 nanocrystalline TiO 的小数量<潜水艇class=“ a-plus-plus ”> 2 @C ( TiO <潜水艇class=“ a-plus-plus ”>在 nanoporous 碳上支持的 2 )合成戏剧性地减少操作温度并且在 NaAlH 为氢存储改进反应动力学<潜水艇class=“ a-plus-plus ”> 4 。nanocrystalline TiO < 潜水艇 class= “ a-plus-plus ” > 2 @C 合成在 900 AVO 八面体综合了是盖住试剂和生长的赞成过度饱和的选择吸附的结果种。随后, 3D 多孔的 V < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 5 八面体被 AVO 八面体的简单 thermolysis 经由一个锻烧处理获得。作为为锂电池的阴极材料,多孔的 V < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 5 八面体阴极在西班牙的北方展出 96 mAsga 盆的一个能力;并且(3 ) Zpy (n ?=? 17 ) , LV 质量从 226 被减少[178;306 ] g 到 220 [169;254 ] g (p ?=? 0.007 ) 在 13 点 ? 桴 ? 畦摮浡湥慴? 牦煥敵据敩 ? 景琠敨猠摥浩湥獴? 敢楳敤琠敨氠湯楧畴楤慮? 湡 ? 牴湡癳牥敳映湵慤敭瑮污映敲畱湥楣獥漠 ? 慥档戠極摬湩 ? 慢敳 ? 湯琠敨愠灭楬畴敤猠数瑣慲愠摮琠敨映潬牯猠数瑣慲? 慲楴?? 剓? 敭桴摯? | Xin Zhang Yongfeng Liu Ke Wang Mingxia Gao Hongge Pan | 2015 | Nano Research2015，8，2： | 8 |
| 20 | Influence of chronic HBV infection on superimposed acute hepatitis E显示文摘AIM:To investigate the influence of chronic hepatitis B virus(HBV)infection[based on the status of hepatitis B e antigen(HBeAg),HBV DNA,and cirrhosis]on superimposed acute hepatitis E.METHODS:A total of 294 patients were recruited from the Department of Infectious Diseases of the Third Affiliated Hospital,Sun Yat-sen University,from January 2003 to January 2012.The patients were classified into two groups:an HBV+hepatitis E virus(HEV)group(a group with chronic HBV infection that was superinfected with acute hepatitis E,n=118)and an HEV group(a group with acute hepatitis E,n=176).We retrospectively analyzed and compared the clinical features of the two groups.Statistical analyses were performed using theχ2test or Fisher’s exact test for categorical variables and the Student’s t test forcontinuous variables.A P value<0.05 was considered statistically significant.RESULTS:The peak values of prothrombin time,serum total bilirubin,and Model for End-Stage Liver Disease scores were significantly higher in the HBV+HEV group.More patients in the HBV+HEV group had complications(39.8%vs 16.5%,P=0.000)and developed liver failure(35.6%vs 8.5%,P=0.000).Additionally,the mortality of the HBV+HEV group was significantly higher(20.3%vs 7.4%,P=0.002).Further analysis of the HBV+HEV group showed that there were no significant differences in complication occurrence,liver failure incidence,or mortality between patients with different HBeAg and HBV DNA statuses.However,in patients with underlying cirrhosis,complication occurrence and liver failure incidence significantly increased.In total,12.7%of the patients in the HBV+HEV group received anti-HBV treatment,but this therapy failed to reduce mortality in patients who developed liver failure.CONCLUSION:The presence of underlying cirrhosis in chronic HBV infection results in more severe clinical outcomes with superimposed acute hepatitis E.AntiHBV treatment cannot improve the prognosis of liver failure caused by HBV-HEV superinfection. | Si-Hong Cheng Li Mai Feng-Qin Zhu Xing-Fei Pan Hai-Xia Sun Hong Cao Xin Shu Wei-Min Ke Gang Li Qi-Huan Xu | 2013 | World Journal of Gastroenterology2013，19，35： | 8 |
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