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| 1 | Rates and impact of hepatitis on human immunodeficiency virus infection in a large African cohort显示文摘AIM:To determine the rates and impact of hepatitis B virus(HBV) and hepatitis C virus(HCV) infections on response to long-term highly active antiretroviral therapy(HAART) in a large human immunodeficiency virus(HIV) population in Nigeria.METHODS:HBV and HCV as well as HIV infections are endemic in sub Saharan Africa.This was a retrospective cohort study of 19 408 adults who were recruited between June 2004 and December 2010 in the AIDS Prevention Initiative in Nigeria in Nigeria programme at Jos University Teaching Hospital.Serological assays,including HBV surface antigen(HBsAg) and hepatitis C antibody were used to categorise hepatitis status of the patients.HBsAg was determined using enzyme immunoassay(EIA)(Monolisa HBsAg Ultra3;Bio-Rad).HCV antibody was tested using third generation EIA(DIA.PRO Diagnostic,Bioprobes srl,Milan,Italy).HIV RNA levels were measured using Roche COBAS Amplicor HIV-1 monitor test version 1.5(Roche Diagnostics,GmbH,Mannheim,Germany) with a detection limit of 400 copies/mL.Flow cytometry was used to determine CD4+ cell count(Partec,GmbH Munster,Germany).Comparison of categorical and continuous variables were achieved using Pearson's χ 2 and Kruskal Wallis tests respectively,on MedCalc for Windows,version 9.5.0.0(MedCalc Software,Mariakerke,Belgium).RESULTS:With an overall hepatitis screening rate of over 90% for each virus;HBV,HCV and HBV/HCV were detected in 3162(17.8%),1983(11.3%) and 453(2.5%) HIV infected adults respectively.The rate of liver disease was low,but highest among HIV monoinfected patients(29,0.11%),followed by HBV coinfected patients(15,0.08%).Patients with HBV coinfection and triple infection had higher log 10 HIV RNA loads(HBV:4.6 copies/mL vs HIV only:4.5 copies/mL,P<0.0001) and more severe immune suppression(HBV:645,55.4%;HBV/HCV:97,56.7%) prior to initiation of HAART compared to HIV mono-infected patients(1852,48.6%)(P<0.0001).Of 3025 patients who were 4.4 years on HAART and whose CD4 cell counts results at baseline and end of follow up were available for analyses,CD4 increase was significantly lower in those with HBV co-infection(HBV:144 cells/mm3 ;HBV/HCV:105 cells/mm3) than in those with HCV co-infection(165 cells/mm3) and HIV mono-infection(150 cells/mm3)(P=0.0008).CONCLUSION:High rates of HBV and HCV infections were found in this HIV cohort.CD4 recovery was significantly diminished in patients with HBV co-infection. | Nimzing Gwamzhi Ladep Patricia Aladi Agaba Oche Agbaji Auwal Muazu Placid Ugoagwu Godwin Imade Graham Cooke Sheena McCormack Simon David Taylor-Robinson John Idoko Phyllis Kanki | 2013 | World Journal of Gastroenterology2013，19，10： | 3 |
| 2 | Myelopoiesis in the zebrafish, Danio rerio显示文摘 | Bennett CM Kanki JP Rhodes J | 2001 | Blood2001，98，3： | 1 |
| 3 | Photocatalytic Reduction and Deposition of Metallic Ions in Aqueous Phase 显示文摘 | Kanki T Yoneda H Sano N | 2004 | Chemical Engineering Journal2004，97，： | 1 |
| 4 | Dynamic change of the chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of HIF1 and KDM3A显示文摘 | Mimura I Nangaku M Kanki Y | 2012 | Mol Cell Biol2012，32，30： | 1 |
| 5 | Hepatic parenchymal enhancement at Gd - EOB - DTPA - enhanced MR imaging: correlation with morphological grading of severity in cirrhosis and chronic hepatitis显示文摘 | KANKI A TAMADA T HIGAKI A | 2012 | Magn Reson Imaging2012，30，3： | 1 |
| 6 | Control of p -type conductivity in Sr doped LaTiO 3 thin films显示文摘 | B. Vilquin T. Kanki T. Yanagida H. Tanaka T. Kawai | 2005 | Solid State Communications2005，，6： | 1 |
| 7 | Antibodies to simian Tlymphotropic retrovirus type Ⅲ in African green monkeys and recognition of STLV-Ⅲ viral proteins by AIDS and related sera显示文摘 | Kanki PJ Kurth R Becker W | 1985 | Lancet1985，1，8441： | 1 |
| 8 | Cytotoxie T-lymphocyte crossreactivity among eifferent humanimmunodeficiency virus type 1 clades : implications for vaccine development 显示文摘 | Cao H Kanki P Sankale JL | 1997 | J Virol1997，71，11： | 1 |
| 9 | Identification d two Fas- associated phosphatase - 1 (FAP-1) pomoters in human cancer cells显示文摘 | Iris S Li Y Kanki H | 2001 | DAN Seq2001，11，6： | 1 |
| 10 | Genome-Wide approaches reveal functional Interleukin-4-Inducible stat6 binding to the vascular cell adhesion molecule 1 promoter显示文摘 | Tozawa H Kanki Y Suehiro J | | 0，，11： | 1 |
| 11 | Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension 显示文摘 | Kanki - Horimoto S Horimoto H Mieno S | 2006 | Circulation2006，114，1： | 1 |
| 12 | Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate显示文摘 | Umenmura T kitamura Y kanki K | 2004 | Cancer Sci2004，95，： | 1 |
| 13 | Hepatic parenchymal en- hancement at Gd-EOPrDTPA-enhanced MR imaging correlation with morphological grading of severity in cirrhosis and chronic hepatitis显示文摘 | Kanki A Tamada T Higaki A | 2012 | Magn Reson Imaging2012，30，3： | 1 |
| 14 | Development of TiO2 photocatalyst reation for water purification 显示文摘 | Zhang Lianfeng Kanki T Sano N | 2008 | Separation and Purification Technology2008，31，1： | 1 |
| 15 | Mitophagy in yeast occurs through a selective mechanism显示文摘 | Kanki T Klionsky DJ | 2008 | J Biol Chem2008，283，32： | 1 |
| 16 | Dose-related changes of oxidative stress and cell proliferation in kidneys of male and fe- male 344 rats exposed to potassium bromated显示文摘 | Umenmura T kitamura Y kanki K | 2004 | Cancer Science2004，95，： | 1 |
| 17 | Human immunodeficiency virus type 1 subtypes differ in disease progression显示文摘 | Kanki PJ Harnel DJ Sankale JL | 1999 | J Infect Dis1999，179，： | 1 |
| 18 | Pentachlorophenol ( but not phenobarbital) promotes intrahepatic biliary cysts induced by diethylnitro sa mi neto ch olangiocy stien eoplasms in B6C3F1 mice possibly due too xidative stress显示文摘 | Umemura T Kodama Y Kanki K | 2003 | Toxicol Pathol2003，31，： | 1 |
| 19 | Human mitochondrial DNA is pack- aged with TFAM 显示文摘 | Alam T I Kanki T Muta T | 2003 | Nucleic Acids Res2003，31，： | 1 |
| 20 | Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast显示文摘 | Kurihara Y Kanki T Aoki Y | 2012 | J Biol Chem2012，287，： | 1 |
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