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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 3 | The chemosensory appendage proteome of Amblyomma americanum (Acari: Ixodidae) reveals putative odorant-binding and other chemoreception-related proteins显示文摘Proteomic 分析在孤独的星的 2 个化学感应的附器上被做滴答响, Amblyomma americanum。蛋白质在在先 tarsi,包含嗅觉的 Hallers 机关,并且在触官,包括味觉的 sensilla,与在第三 tarsi 的蛋白质相比。另外,男性和女性滴答响被比较。蛋白质被顺序类似,并且由 3-dimensional 相同建模识别到已知的蛋白质。Proteomic 数据也与从 tick Rhipicephalus microplus 的器官特定的 transcriptomes 相比。在先 tarsi 快车没在第三 tarsi 或触官发现的 lipocalin。在先, tarsi 和触官富有地表示 2 蛋白质,它类似于昆虫有气味的东西绑定蛋白质(OBP ) 。与昆虫 OBP 相比, tick 象 OBP 一样序列缺乏半胱氨酸在 C 减 OBP 不在,并且 1 滴答响象 OBP 一样顺序有类似于 C 加 OBP 的另外的半胱氨酸。类似于抗菌素蛋白质 microplusin 的四蛋白质被发现:2 只表示了在在先 tarsi 并且 1 只在触官表示了。这些蛋白质缺乏 microplusin 铜绑定地点,而是他们被建模有一个重要的内部洞,潜在地一个 ligand 有约束力的地点。类似于 7 被发现差别的灰尘螨变应原 Der p7 和 Der f 的蛋白质在先在女性表示了 tarsi。只表示在的蛋白质在先, tarsi 有类似到否决权,它被知道涉及 ionotropic glutamate 受体聚类。这些结果组成象 OBP 一样蛋白质序列的第一份报告在滴答响并且点到几条研究大街在上滴答响化学感应的接收。 | Robert Renthal Leena Manghnani Sandra Bernal Yanyan Qu Wendell P. Griffith Kim Lohmeyer Felix O. Guerrero Ligia M.F. Borges Adalberto Perez de Leon | 2017 | Insect Science2017，24，5： | 4 |
| 4 | Morris-Lecar model of third-order barnacle muscle fiber is made of volatile memristors显示文摘Plenty of studies were introduced to understandthe various properties of biological membranes.Hodgkin-Huxley (HH) axon model [1] is oneamong those studies which describes the initiationand propagation of an action potential in squid gi-ant axon membrane. Recently, Ref. [2] claimedthat according to the basic electrical circuit the-ory, the time-varying sodium and potassium con-ductance are actually time-invariant sodium andpotassiunl generic memristors. | Vetriveeran RAJAMANI Hyongsuk KIM Leon CHUA | 2018 | Science China(Information Sciences)2018，61，6： | 4 |
| 5 | PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers 显示文摘 | Jin G Kim M J leon HS | 2010 | Lung Cancer2010，69，3： | 1 |
| 6 | On Fidelity and Model Selection for Discrete Event Simulation 显示文摘 | Hansoo Kim Leon F McGinnis Chen Zhou | 2012 | SAGE2012，88，1： | 1 |
| 7 | Effects of interdiffusion on the luminescence of InGaAs/GaAs quantum dots显示文摘 | LEON R KIM Y JAGADISH C | 1996 | Appl Phys Lett1996，69，： | 1 |
| 8 | Characterization of the structural gene encoding nisin F,a new lantibiotic produced by a Lactococcus lactis subsp,lactis isolate from freshwa-ter catfish(Clarias gariepinus)显示文摘 | De Kwaadsteniet Michele Ten Doeschate Kim Dicks Leon Milner Theodore | 2008 | Applied and Enviromnentai Micro-biology2008，74，2： | 1 |
| 9 | Cooperative control strategy of energy storage system and microsourees for stabilizing the microgrid during islanded operation显示文摘 | Kim Jong-Yul leon Jin-Hong Kim Seul-Ki | 2010 | IEEE Transactions on Power Electronics2010，25，12： | 1 |
| 10 | In vivo Reduction of Hepatitis B Virus Antigenemia and Viremia by Antisense Oligonucleotides显示文摘 | Gaetan Billioud Robert L. Kruse Melissa Carrillo Christina Whitten-Bauer Dacao Gao Aneeza Kim Leon Chen Michael L. McCaleb Jeffrey R. Crosby Robert Hamatake Zhi Hong Urtzi Garaigorta Eric Swayze Karl-Dimiter Bissig Stefan Wieland | 2015 | Journal of Hepatology2015，，： | 1 |
| 11 | Analytical studies of full-scale steel T-stub connections using delicate 3d finite element methods显示文摘 | Hu J W Kim D K Leon R T | 2011 | ISIJ International2011，51，4： | 1 |
| 12 | Blindness and Visual Impairment in an Urban West African Population: The Tema Eye Survey显示文摘 | Donald L. Budenz Jagadeesh R. Bandi Keith Barton Winifred Nolan Leon Herndon Julia Whiteside-de Vos Graham Hay-Smith Hanna Kim James Tielsch | 2012 | Ophthalmology2012，，9： | 1 |
| 13 | Poly(Lactide-co-glycolide}/ Hydroxyapatite Composite Scaffolds for Bone Tissue Engineering显示文摘 | Kim SS Sun Park M leon 0 | 2006 | Biomaterials2006，27，8： | 1 |
| 14 | Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer’s disease显示文摘 | Yi Li Juha O. Rinne Lisa Mosconi Elizabeth Pirraglia Henry Rusinek Susan DeSanti Nina Kemppainen Kjell N?gren Byeong-Chae Kim Wai Tsui Mony J. Leon | 2008 | European Journal of Nuclear Medicine and Molecular Imaging2008，，12： | 1 |
| 15 | Clinical heterogeneity of extranodal NK/T-cell lymphoma,nasal type: a national survey of the Korean Cancer Study Group显示文摘 | Kim TM Lee SY Leon YK | 2008 | Ann Oncol2008，19，8： | 1 |
| 16 | Trehalose accumulation in rice plants confers high tolerance levels to different abiotic stresses显示文摘 | Garg Ajay K Kim Ju Kon Owents Thomas G Ranwala Anil P Choi Yang Do Koehian Leon V and Wu Ray J | 2002 | PNAS2002，99，15： | 1 |
| 17 | Nosoeomial outbreak ofcarbapenem-resistant Acinetobacter baumannii in intensive care units and successful outbreak control program显示文摘 | Choi WS Kim Ski leon EG | 2010 | J Korean Med Sci2010，25，7： | 1 |
| 18 | Risk and protective factors in young children、adjust-ment to parental divorce: A review of the research显示文摘 | KIM LEON | 2003 | Fam Relat2003，52，： | 1 |
| 19 | Hemimasticatory spasm associated with localized scleroderma and facial hemiatrophy显示文摘 | Kim HI leon BS Lee KW | 2000 | Arch N eurol2000，57，： | 1 |
| 20 | Graded methionine dietary inclusions influence growth performance and apparent ileal amino acid digestibility coefficients and disappearance rates in broiler chickens显示文摘Graded quantities of 1.38,2.76 and 4.14 g/kg L-methionine were included in a control diet formulated to contain 3.07 g/kg digestible methionine.Each of the 4 dietary treatments was offered to 6 replicate cages(initially 8 birds per cage)from 1 to 21 d postehatch.The parameters assessed included growth performance,nutrient utilisation(apparent metabolisable energy[AME],AME:GE ratios,N retention,Ncorrected apparent metabolisable energy[AMEn]),apparent digestibility coefficients and disappearance rates of amino acids in the distal ileum.They also included free amino concentrations in systemic plasma(brachial vein)at 20 d postehatch and in hepatic tissue at 14 and 21 d postehatch.Graded L-methionine inclusions quadratically influenced weight gain(r=0.688;P=0.001)and FCR(r=0.780;P<0.001).It may be deduced from the quadratic regressions that 3.43 g/kg L-methionine supported maximum weight gain of 1,036 g/kg and 3.50 g/kg L-methionine minimum FCR of 1.193,from 1 to 21 d postehatch.The control diet contained specified levels of 3.07 g/kg digestible methionine and 13.0 g/kg digestible lysine.Thus,an inclusion of 3.465 g/kg L-methionine corresponded to a total of 6.535 g/kg methionine or a methionine-to-lysine ratio of 50.3,which is higher than standard recommendations.The implications of this and other outcomes of the present study are reported and discussed. | Shemil P.Macelline Peter V.Chrystal Leon R.McQuade Bernard V.Mclnerney Yangsu Kim Yumin Bao Peter H.Selle Sonia Y.Liu | 2022 | Animal Nutrition2022，，1： | 0 |
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