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| 1 | A genome-wide association study uncovers a critical role of the RsPAP2 gene in red-skinned Raphanus sativus L.显示文摘Radish(Raphanus sativus L.)taproot contains high concentrations of flavonoids,including anthocyanins(ATCs),in redskinned genotypes.However,little information on the genetic regulation of ATC biosynthesis in radish is available.A genome-wide association study of radish red skin color was conducted using whole-genome sequencing data derived from 179 radish genotypes.The R2R3-MYB transcription factor production of anthocyanin pigment 2(PAP2)gene was found in the region associated with a leading SNP located on chromosome 2.The amino acid sequence encoded by the RsPAP2 gene was different from those of the other published RsMYB genes responsible for the red skin color of radish.The overexpression of the RsPAP2 gene resulted in ATC accumulation in Arabidopsis and radish,which was accompanied by the upregulation of several ATC-related structural genes.RsPAP2 was found to bind the RsUFGT and RsTT8 promoters,as shown by a dual-luciferase reporter system and a yeast one-hybrid assay.The promoter activities of the RsANS,RsCHI,RsPAL,and RsUFGT genes could be strongly activated by coinfiltration with RsPAP2 and RsTT8.These findings showed the effectiveness of GWAS in identifying candidate genes in radish and demonstrated that RsPAP2 could(either directly or together with its cofactor RsTT8)regulate the transcript levels of ATC-related genes to promote ATC biosynthesis,facilitating the genetic enhancement of ATC contents and other related traits in radish. | Lianxue Fan YanWang Liang Xu Mingjia Tang Xiaoli Zhang Jiali Ying Cui Li Junhui Dong Liwang Liu | 2020 | Horticulture Research2020，7，1： | 2 |
| 2 | Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization显示文摘DNA 免疫是为高亲密关系的 monoclonal 抗体产生的一个有效方法。这里,我们对松香油绑定蛋白质 4 描述几高质量的 monoclonal 抗体(mAbs ) 的产生(RBP4 ) ,为肾反常和机能障碍的一个重要标记,与 DNA 的一个联合方法, priming 和蛋白质增加。产生的 mAbs 能与高敏感并且用这些 mAbs 绑在 RBP4,一块 immunocolloidal 金牌快测试长带被构造。长带能交上结果 < 5 min 并且与大约 1 ng/ml 的察觉限制是很敏感的。小规模的临床的测试表明这脱衣的结果根据在市场上当前可得到的一个标记酶的 immunosorbent 试金工具包的好。因而,它能为在诊所的更方便、更快的 RBP4 决心是有用的。 | Chao Bian Fang Zhang Feng Wang Zhiyang Ling Min Luo Hongqiang Wu Yizhuo Sun Junhui Li B ingnan Li Jingyan Zhu Linna Tang Yanyan Zhou Qunfang Shi Yongyong Ji Lin Tian Guomei Lin Yu Fan Niansong Wang Bing Sun | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 2 |
| 3 | 202 W dual-end-pumped Tm:YLF laser with a VBG as an output coupler显示文摘We demonstrated a 202 W Tm:YLF slab laser using a reflecting volume Bragg grating(VBG)as an output coupler at room temperature.Two kinds of active heat dissipation methods were used for the VBG to suppress the shift of wavelength caused by its increasing temperature.The maximum continuous wave(CW)output power of 202 W using the microchannel cooling was obtained under the total incident pump power of 553 W,the corresponding slope efficiency and optical-to-optical conversion efficiency were 39.7%and 36.5%,respectively.The central wavelength was 1908.5 nm with the linewidth(full width at half maximum)of 0.57 nm.Meanwhile,with the laser output increasing from 30 to 202 W,the total shift was about 1.0 nm,and the wavelength was limited to two water absorption lines near 1908 nm.The beam quality factors M;were measured to be 2.3 and 4.0 in x and y directions at 202 W. | Disheng Wei Shuyi Mi Ke Yang Junhui Li Jinwen Tang Baoquan Yao Tongyu Dai Xiaoming Duan | 2021 | High Power Laser Science and Engineering2021，9，4： | 1 |
| 4 | Model-based steganalytic method towards color JPEG images显示文摘 | He Junhui Tang Shaohua Li Bin | 2007 | Journal of Computational Information Systems2007，3，6： | 1 |
| 5 | UU_* filtering of nighttime net ecosystem CO_2 exchange flux over forest canopy under strong wind in wintertime显示文摘 | ZHANG Junhui, HAN Shijie, SUN Xiaomin & TANG Fengde Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Department of Environment and Life Sciences, Liaoning University, Shenyang 110036, China | 2005 | Science China Earth Sciences2005，48，z1： | 1 |
| 6 | Superhydrophobic titania membranes of different adhesive forces fabricated by electrospinning 显示文摘 | TANG Hongzhe WANG Hong HE Junhui | 2009 | J Phys Chem C2009，113，14： | 1 |
| 7 | A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still rapidly spreading worldwide.Many drugs and vaccines have been approved for clinical use show efficacy in the treatment and prevention of SARS-CoV-2 infections.However,the emergence of SARS-CoV-2 variants of concern(VOCs),such as Delta(B.1.617.2)and the recently emerged Omicron(B.1.1.529),has seriously challenged the application of current therapeutics.Therefore,there is still a pressing need for identification of new broad-spectrum antivirals.Here,we further characterized a human antibody(58G6),which we previously isolated from a patient,with a broadly authentic virus-neutralizing activity that inhibits the Delta and Omicron variants with half-maximal inhibitory concentrations(ICso)of 1.69 ng/ml and 54.31 ng/ml,respectively.58G6 shows prophylactic and therapeutic effcacy in hamsters challenged with the Delta and Omicron variants through nasal delivery.Notably,a very low dosage(2 mg/kg daily)of 58G6 efficiently prevented Omicron variant replication in the lungs.These advantages may overcome the efficacy limitation of currently approved neutralizing antibodies that can be administered only by intravenous injection.In general,58G6 is a promising prophylactic and therapeutic candidate against current circulating VOCs and even future emerging mutants.To the best of our knowledge,58G6 is one of the most potent neutralizing antibodies against Omicron,with a broader spectrum than those approved for clinical use.58G6 could be developed as a nebulized therapy,which would be more cost effective and user friendly and enhance the clinical outcome comparedto thatobtainedwithdirect nasaldelivery. | Xinghai Zhang Huajun Zhang Tingting Li Shaohong Chen Feiyang Luo Junhui Zhou Peiyi Zheng Shuyi Song Yan Wu Tengchuan Jin Ni Tang Aishun Jin Chengyong Yang Guofeng Cheng Rui Gong Sandra Chiu Ailong Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 8 | Fabrication of aligned ferrite nanofibers by magneticfield-assisted electrospinning coupled with oxygen plasma treatment显示文摘 | WANG Hang TANG Hongzhe HE Junhui | 2009 | Materials Research Bulletin2009，44，8： | 1 |
| 9 | A simple,rapid and effective method for total RNA extraction from Lentinula e-dodes显示文摘 | Li Junhui Tang Chuanhong Song Chunyan | 2006 | Biotechnol Lett2006，28，15： | 1 |
| 10 | Reactive oxygen species accumulation patterns of alfalfa root nodules identified using an optimized method显示文摘ROS include superoxide anion radical (O2^-), hydrogen peroxide (H2O2), singlet oxygen (0-0), hydroxyl radical (OH ), and hydroxyl anion (OH-). O2^-, the radical with the highest oxidation compacity to produce H2O2, OH and OH^-, is a byproduct of aerobic respiration in organisms. Rhizobia and their legume hosts are aerobic organisms, and nitrogen-fixing nodules formed on legume roots are developed from their symbiotic in teractions. Therefore, ROS are generated in legume nodules through aerobic respiration by both symbiotic partners. | Liangliang Yu Leqi Huang Shuang Zeng Guirong Tang Sunjun Wang Ningning Li Junhui Yan Li Luo | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 0 |
| 11 | Melatonin-induced DNA demethylation of metal transporters and antioxidant genes alleviates lead stress in radish plants显示文摘Melatonin(MT)is a tryptophan-derived natural product that plays a vital role in plant response to abiotic stresses,including heavy metals(HMs).However,it remains elusive how exogenous MT mediates lead(Pb)accumulation and detoxification at the methylation and transcriptional levels in radish.In this study,decreased Pb accumulation and increased antioxidant enzyme activity were detected under MT treatment in radish.Single-base resolution maps of DNA methylation under Pb stress(Pb200)and Pb plus MT treatment(Pb_50MT)were first generated.The genome-wide methylation level was increased under Pb stress,while an overall loss of DNA methylation was observed under MT treatment.The differentially methylated region(DMR)-associated genes between Pb_50MT and Pb200 were uniquely enriched in ion binding terms,including cation binding,iron ion binding,and transition metal ion binding.Hyper-DMRs between Pb200 and Control exhibited a decreasing trend of methylation under Pb_50MT treatment.A few critical upregulated antioxidant genes(e.g.,RsAPX2,RsPOD52 and RsGST)exhibited decreased methylation levels under MT treatment,which enabled the radish plants to scavenge lead-induced reactive oxygen species(ROS)and decrease oxidative stress.Notably,several MT-induced HM transporter genes with low methylation(e.g.,RsABCF5,RsYSL7 and RsHMT)and transcription factors(e.g.,RsWRKY41 and RsMYB2)were involved in reducing Pb accumulation in radish roots.These findings could facilitate comprehensive elucidation of the molecular mechanism underlying MT-mediated Pb accumulation and detoxification in radish and other root vegetable crops. | Mingjia Tang Liang Xu Yan Wang Junhui Dong Xiaoli Zhang Kai Wang Jiali Ying Cui Li Liwang Liu | 2021 | Horticulture Research2021，8，1： | 0 |
| 12 | Automatic test system development for digital beam position monitor of HEPS and BEPCII显示文摘Purpose Hundreds of digital beam position monitor processors(DBPM)are required to be produced during the construction of projects such as High Energy Photon Source(HEPS)and the upgrade project of the Beijing Electron Positron Collider(BEPCII),which brings great challenges to the test work.In order to achieve accurate,fast,and complete mass production tests of DBPMs,an automatic test system(ATS)has been developed in this article.Methods According to the test items of DBPM,the standardized testing softwareflow is designed based on virtual instru-ment program control technology and experimental physics and industrial control system(EPICS),which realize automatic adjustment of test parameters and automatic acquisition of test result data.Results and conclusions The ATS can realize one-button testing of channel coefficients,channel linearity,attenuator linearity,beam current dependence(BCD)and sampling signal-to-noise ratio(SNR),and generate test reports.The total test time is less than 3 minutes,which is significantly more efficient compared to manual testing.More than 90 BEPCII DBPMs has been tested by this ATS in the lab.The test results proved that such a system could automatically recognize defective products and satisfy the requirements of mass testing. | Xuhui Tang Yaoyao Du Jianshe Cao Shujun Wei Zhi Liu Qiang Ye Huizhou Ma Jing Yang Guodong Gao Yukun Li Yanfeng Sui Junhui Yue | 2022 | Radiation Detection Technology and Methods2022，6，3： | 0 |
| 13 | Twinning-induced plasticity(TWIP)effect in multi-phase metastable beta Zr-Nb alloys显示文摘During the last decades,a large amount of scientific works had been devoted toβ-type Zr and Ti alloys for biomedical applica-tions due to their high strength,good corrosion resistance,low magnetic susceptibility and superior biocompatibility[1]. | Junhui Tang Ahmed Zorgati Jean-Baptiste Philippe Vermaut Frédéric Prim Fan Sun | 2023 | Journal of Materials Science & Technology2023，，8： | 0 |
| 14 | Mesenchymal stem cell-derived exosomes: Versatile nanomaterials for skin wound treatment显示文摘Accumulating studies reveal that mesenchymal stem cells(MSCs)promote skin wound healing mainly through the paracrine effects.Exosomes,one of the crucial paracrine mediators in wound healing,are cell-derived nanosized membranous vesicles containing diverse bioactive cargoes.With the potent ability of modulating skin cell behaviors,MSC-derived exosomes(MSC-Exos)are regarded as a promising nanomaterial for regenerative wound therapy.Under hostile conditions,MSC-Exos are efficient in protecting skin cells from severe damage and restoring their function.According to recent studies,MSC-Exos possess remarkable pro-healing effects in a variety of skin wounds,typically resulting in increased wound closure,inhibited scar tissue formation,and better restoration of skin function.To further enhance the therapeutic potential of MSC-Exos,the development of applicable pretreatment strategies and the optimization of exosome delivery are under intensive investigation.Herein,we summarize current research progress of MSC-Exos for skin wound treatment,with an emphasis on the biological effects of these nanovesicles,the repair mechanisms,and future challenges in clinical translation. | Yuzhen Xiao Hexi Li Junhui Zhang Songyun Yang Chunsen Zhang Yizhou Huang Xin Tang Huiqi Xie | 2024 | Nano Research2024，17，4： | 0 |
| 15 | Giant electrorheological effects of aluminum-doped TiO_2 nanoparticles显示文摘Titania nanoparticles doped with cations have been synthesized via a modified hydrolysis method.The X-ray diffraction analyses,scanning electron microscopy and other characteristics measurements,were used to study the structure of the nanoparticles.The results showed interesting electrorheological(ER) effect with titania nanoparticles modified by aluminum ions,and different cations on ER effect were determined by ionic potential and resistance of the particle aggregates in the electric field.The doping ratio of aluminum ions was dominated by the appropriate sites of the particle surface and the ER effect strongly depends on the doping ratio. | Hongzhe Tang Junhui He Jacques Persello | 2010 | Particuology2010，8，5： | 0 |
| 16 | Identification of Sinorhizobium meliloti LsrB regulon显示文摘Redox homeostasis determines cell fate for both prokaryotes and eukaryotes.In bacteria,redox state depends on aerobic respiration and antioxidant protection.Superoxide anion radicals produced from aerobic respiration are catalyzed by superoxide dismutase(SOD)to hydrogen peroxide(H_(2)O_(2)). | Fang An Ningning Li Lanya Zhang Wenjia Zheng Shenghui Xing Guirong Tang Junhui Yan Liangliang Yu Li Luo | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 0 |
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