|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of penehyclidine in acute organophosphorus pesticide poisoning显示文摘BACKGROUND:Penehyclidine is a newly developed anticholinergic agent.We aimed to investigate the role of penehyclidine in acute organophosphorus pesticide poisoning(OP)patients.METHODS:We searched the Pubmed,Cochrane library,EMBASE,Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical literature(CBM)and Wanfang databases.Randomized controlled trials(RCTs)recruiting acute OP patients were identifi ed for meta-analysis.Main outcomes included cure rate,mortality rate,time to atropinization,time to 60%normal acetylcholinesterase(AchE)level,rate of intermediate syndrome(IMS)and rate of adverse drug reactions(ADR).RESULTS:Sixteen RCTs involving 1,334 patients were identifi ed.Compared with the atropineor penehyclidine-alone groups,atropine combined with penehyclidine significantly increased the cure rate(penehyclidine+atropine vs.atropine,0.97 vs.0.86,RR 1.13,95%CI[1.07–1.19];penehyclidine+atropine vs.penehyclidine,0.93 vs.0.80,RR 1.08,95%CI[1.01–1.15])and reduced the mortality rate(penehyclidine+atropine vs.atropine,0.015 vs.0.11,RR 0.17,95%CI[0.06–0.49];penehyclidine+atropine vs.penehyclidine,0.13 vs.0.08,RR 0.23,95%CI[0.04–1.28]).Atropine combined with penehyclidine in OP patients also helped reduce the time to atropinization and AchE recovery,the rate of IMS and the rate of ADR.Compared with a single dose of atropine,a single dose of penehyclidine also signifi cantly elevated the cure rate,reduced times to atropinization,AchE recovery,and rate of IMS.CONCLUSION:Atropine combined with penehyclidine benefi ts OP patients by enhancing the cure rate,mortality rate,time to atropinization,AchE recovery,IMS rate,total ADR and duration of hospitalization.Penehyclidine combined with atropine is likely a better initial therapy for OP patients than atropine alone. | Shi-yuan Yu Yan-xia Gao Joseph Walline Xin Lu Li-na Zhao Yuan-xu Huang Jiang Tao An-yong Yu Na Ta Ren-ju Xiao Yi Li | 2020 | World Journal of Emergency Medicine2020，11，1： | 18 |
| 2 | Carbamylated erythropoietin regulates immune responses and promotes long-term kidney allograft survival through activation of PI3K/AKT signaling显示文摘Modulation of alloimmune responses is critical to improving transplant outcome and promoting long-term graft survival.To determine mechanisms by which a nonhematopoietic erythropoietin(EPO)derivative,carbamylated EPO(CEPO),regulates innate and adaptive immune cells and affects renal allograft survival,we utilized a rat model of fully MHC-mismatched kidney transplantation.CEPO administration markedly extended the survival time of kidney allografts compared with the transplant alone control group.This therapeutic effect was inhibited when the recipients were given LY294002,a selective inhibitor of the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway or anti-EPO receptor(EPOR)antibody,in addition to CEPO.In vitro,CEPO inhibited the differentiation and function of dendritic cells and modulated their production of proinflammatory and anti-inflammatory cytokines,along with activating the PI3K/AKT signaling pathway and increasing EPOR mRNA and protein expression by these innate immune cells.Moreover,after CD4^(+)T cells were exposed to CEPO the Th1/Th2 ratio decreased and the regulatory T cell(Treg)/Th17 ratio increased.These effects were abolished by LY294002 or anti-EPOR antibody,suggesting that CEPO regulates immune responses and promotes kidney allograft survival by activating the PI3K/AKT signaling pathway in an EPOR-dependent manner.The immunomodulatory and specific signaling pathway effects of CEPO identified in this study suggest a potential therapeutic approach to promoting kidney transplant survival. | Ning Na Daqiang Zhao Jinhua Zhang Jiaqing Wu Bin Miao Heng Li Yingxun Luo Zuofu Tang Wensheng Zhang Joseph A.Bellanti Song Guo Zheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 3 | Hemodynamic characteristics in preeclampsia women during cesarean delivery after spinal anesthesia with ropivacaine显示文摘BACKGROUND Very few studies have been published on the hemodynamic changes associated with spinal anesthesia induced with ropivacaine during cesarean deliveries in preeclamptic women.AIM To record and analyze hemodynamic data in women with preeclampsia undergoing cesarean delivery after spinal anesthesia induced with ropivacaine.METHODS Ten eligible women with preeclampsia were enrolled in this prospective observational study.Spinal anesthesia was performed with 2.4 mL of 0.5%ropivacaine.Hemodynamic changes were then analyzed at multiple time points.The hemodynamic responses to vasopressor interventions and uterotonic agents,as well as maternal and neonatal outcomes were also recorded.RESULTS Stable hemodynamic trends were observed in this study.Cardiac output(CO)and stroke volume increased mildly during surgery.In contrast,mean arterial pressure and systemic vascular resistance showed a moderate decrease from induction until the end of surgery.Central venous pressure dramatically increased after delivery.Oxytocin administration was associated with the most significant hemodynamic fluctuations during surgery,namely,an increase in CO and heart rate.Phenylephrine intervention was only required in three patients,and caused an increase in mean arterial pressure and systemic vascular resistance along with a decrease in heart rate,stroke volume,and CO.No maternal and neonatal complications were observed during this study,except transient episodes of hypotension.CONCLUSION Spinal anesthesia for caesarian delivery with ropivacaine in women with preeclampsia is linked to modest hemodynamic changes of no clinical significance in this study.Careful cardiovascular monitoring is still recommended,particularly after the delivery of the fetus or the use of oxytocin. | Na Zhao Jin Xu Xiao-Guang Li Joseph Harold Walline Yi-Chong Li Lin Wang Guo-Sheng Zhao Ming-Jun Xu | 2020 | World Journal of Clinical Cases2020，8，8： | 4 |
| 4 | Printable Aligned Single-Walled Carbon Nanotube Film with Outstanding Thermal Conductivity and Electromagnetic Interference Shielding Performance显示文摘Ultrathin,lightweight,and flexible aligned single-walled carbon nanotube(SWCNT)films are fabricated by a facile,environmentally friendly,and scalable printing methodology.The aligned pattern and outstanding intrinsic properties render“metal-like”thermal conductivity of the SWCNT films,as well as excellent mechanical strength,flexibility,and hydrophobicity.Further,the aligned cellular microstructure promotes the electromagnetic interference(EMI)shielding ability of the SWCNTs,leading to excellent shielding effectiveness(SE)of~39 to 90 dB despite a density of only~0.6 g cm^(−3) at thicknesses of merely 1.5-24μm,respectively.An ultrahigh thickness-specific SE of 25693 dB mm^(−1) and an unprecedented normalized specific SE of 428222 dB cm^(2)g^(−1) are accomplished by the freestanding SWCNT films,significantly surpassing previously reported shielding materials.In addition to an EMI SE greater than 54 dB in an ultra-broadband frequency range of around 400 GHz,the films demonstrate excellent EMI shielding stability and reliability when subjected to mechanical deformation,chemical(acid/alkali/organic solvent)corrosion,and high-/low-temperature environments.The novel printed SWCNT films offer significant potential for practical applications in the aerospace,defense,precision components,and smart wearable electronics industries. | Zhihui Zeng Gang Wang Brendan F.Wolan Na Wu Changxian Wang Shanyu Zhao Shengying Yue Bin Li Weidong He Jiurong Liu Joseph W.Lyding | 2022 | Nano-Micro Letters2022，14，11： | 4 |
| 5 | Long-term dietary strawberry,spinach,or Vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits显示文摘 | Joseph JA Shukitt-Hale B Denisova NA | 1998 | J Neurosci1998，18，： | 1 |
| 6 | Reversals of age-related declines in neuronal signal transduction,cognitive and motor behavioral deficits with blueberry,spinach or strawberry dietary supplementation显示文摘 | Joseph JA Shukitt-Hale B Denisova NA | 1999 | J Neurosci1999，19，： | 1 |
| 7 | Adipocytokines and insulin resistance显示文摘 | Pittas AG Joseph NA Greenberg AS | 2004 | J Clin Endocrinol Metab2004，89，2： | 1 |
| 8 | Adipocytokines and insulin resistance显示文摘 | Pittas AG Joseph NA Greenberg AS | 2004 | J Clin Endocrinol Metab2004，89，2： | 1 |
| 9 | AdiPocytokines and/insulin Resist- ance 显示文摘 | Pittas AC JosePh NA Greenberg AS | 2004 | J Clin Endocrinol Metab2004，89，2： | 1 |
| 10 | Adipocytokines and insulin resistance显示文摘 | Pittas AG Joseph NA Greenberg AS | 2004 | J Clin Endocrinol Metab2004，89，2： | 1 |
| 11 | Adipocytokines and insulin resistance显示文摘 | Pittas AG Joseph NA Greenberg AS | 2004 | JClin Endocrinol Metab2004，89，2： | 1 |
| 12 | Adipoeytokines and insulin resistance显示文摘 | Pittas AG Joseph NA Greenberg AS | 2004 | J Clin Endoerinol Metab2004，89，2： | 1 |
| 13 | Reversals of age - related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation显示文摘 | Joseph JA Shukitt Hale B Denisova NA | 1999 | J Neurosci1999，19，： | 1 |
| 14 | Adipocytokines and Insulin Resistance显示文摘 | Pittas AG Joseph NA Greenberg AS | 2004 | J Clin Endocrinol Metab2004，89，2： | 1 |
| 15 | Copernicus revi-sited: Amylord beta in Alzheimer's disease显示文摘 | Shukitt-Hale B Denisora NA | 2001 | Neurobiol Aging2001，22，： | 1 |
| 16 | Pharmacology of intrathecally administered agents for treatment of spasticity and pain 显示文摘 | Hayek SM Joseph PN Mekhail NA | 2003 | Semin in Pain Med2003，1，4： | 1 |
| 17 | Adipocytokines and insulin resistance显示文摘 | Pittas AG Joseph NA Greenberg AS | | 0，，02： | 1 |
| 18 | HIV Incidence and Associated Factors in a Cohort of Men Who Have Sex With Men in Nanjing, China显示文摘 | Haitao Yang Chun Hao Xiping Huan Hongjing Yan Wenhui Guan Xiaoqin Xu Min Zhang Weiming Tang Na Wang Joseph T. F. Lau | 2010 | Sexually Transmitted Diseases2010，，4： | 1 |
| 19 | Adipocytokines and insulin resistance显示文摘 | Pittas AG Joseph NA Greenberg AS | | 0，，02： | 1 |
| 20 | Adipocytokines and insulin resistance显示文摘 | Pittas AG Joseph NA Greenberg AS | 2004 | J Clin Endocrinol Metab2004，89，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员