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| 1 | 长链脂肪乳剂及中/长链脂肪乳剂水解速率的比较研究显示文摘目的 :比较长链脂肪乳剂、物理混合的中 /长链脂肪乳剂及结构脂肪乳剂的水解速率。 方法 :应用 1 1 4 C甘油棕榈酸标记的长链三酰甘油 (LCT)和 2 ,3 3 H甘油辛酸标记的中链三酰甘油 (MCT) ,分别标记Intralipid ,Lipo fundin及Structolipid ,在体外添加缓冲液、脂蛋白酯酶和肝酯酶后 ,置 37℃温箱中水浴、孵育。采用气相色谱仪测定核素标记的各种脂肪酸及三酰甘油浓度 ,游离脂肪酸浓度用放射性核素扫描计数测定 ,通过计算培养液中1 4 C标记的长链脂肪酸及3 H标记的中链脂肪酸分别在1 4 C标记LCT及3 H标记MCT中的比例 ,来计算三种脂肪乳剂的水解率。 结果 :物理混合的中 /长链脂肪乳剂及结构脂肪乳剂的水解程度明显高于长链脂肪乳剂 ,差异有统计学意义。物理混合的中 /长链脂肪乳剂水解程度高于结构脂肪乳剂 ,但在水解程度及水解速度上却无统计学差异。 结论 :物理混合的中 | 吴国豪 Connie Jarstrand Jorgen Nordenstrom | 2002 | 肠外与肠内营养2002，9，1： | 13 |
| 2 | Anastomotic leakage in rectal cancer surgery:The role of blood perfusion显示文摘Anastomotic leakage after anterior resection for rectal cancer remains a common and often devastating complication. Preoperative risk factors for anastomotic leakage have been studied extensively and are used for patient selection, especially whether to perform a diverting stoma or not. From the current literature,data suggest that perfusion in the rectal stump rather than in the colonic limb may be more important for the integrity of the colorectal anastomosis. Moreover, available research suggests that the mid and upper rectum is considerably more vascularized than the lower part, in which the posterior compartment seems most vulnerable. These data fit neatly with the observation that anastomotic leaks are far more frequent in patients undergoing total compared to partial mesorectal excision, and also that most leaks occur dorsally. Clinical judgment has been shown to ineffectively assess anastomotic viability, while promising methods to measure blood perfusion are evolving. Much interest has recently been turned to near-infrared light technology, enhanced with fluorescent agents, which enables intraoperative perfusion assessment. Preliminary data are promising, but large-scale controlled trials are lacking. With maturation of such technology, perfusion measurements may in the future inform the surgeon whether anastomoses are at risk. In high colorectal anastomoses, anastomotic revision might be feasible, while a diverting stoma could be fashioned selectively instead of routinely for low anastomoses. | Martin Rutegard Jorgen Rutegard | 2015 | World Journal of Gastrointestinal Surgery2015，7，11： | 10 |
| 3 | 肠外营养时不同脂肪乳剂对粒细胞功能的影响显示文摘目的 比较静脉输注长链及中长链脂肪乳剂时对粒细胞功能的影响。 方法 选择18位健康志愿者进行前瞻性随机交叉对照研究 ,连续输注MCT/LCT或LCT(TG :0 .15 g·kg-1·h-1) ,在研究前及输注中 2h、4h及 2 4h分别抽血提取多核白细胞作趋向性、自发游动、吞噬能力、杀菌率及吞噬过程中氧化代谢测定。 结果 静脉输注脂肪乳剂时多核白细胞的趋向性和自发游动能力无明显改变 (P >0 .0 5 ) ,但多核白细胞的吞噬及杀菌能力下降 (P <0 .0 5 ) ,两种脂肪乳剂之间无统计学差异 (P >0 .0 5 )。静脉输注脂肪乳剂可明显抑制NBT值 (P <0 .0 5 ) ,且LCT的抑制程度要大于MCT/LCT(P <0 .0 5 )。 结论 静脉输注脂肪乳剂可影响粒细胞吞噬、杀菌及氧化代谢能力 ,但对粒细胞的趋向性及自发游动能力无明显影响。长链及中 /长链脂肪乳剂在对粒细胞功能的影响上无明显差异。 | 吴国豪 Connie Jarstrand Jorgen Nordenstrom | 2001 | 中国临床营养杂志2001，9，4： | 3 |
| 4 | Evaluation of a new qPCR test to identify the organisms causing high total bacterial count in bulk tank milk显示文摘Milk quality in bulk tank milk(BTM)is measured by flow cytometry technology as total bacterial count(TBC)and somatic cell count(SCC).To investigate SCC problems,culture or PCR can be used to identify mastitis causing bacteria,e.g.,Mastit 4,a commercially available qPCR test.TBC in BTM can be investigated further using culture-based methods such as standard plate count,laboratory pasteurization count,coliform count,and spore counts.To our knowledge,no qPCR addressing the bacteria involved in TBC has been commercially introduced.The aim of this study is to evaluate a recently introduced 3-h qPCR test,TBC 4.The TBC 4 qPCR detects four target groups,Pseudomonas,Streptococci,Enterobacteriacea/Enterococcus,and Bacillus/Clostridia.These target groups relate to problems on the farm such as cooling,mastitis,environment,and silage.We will continue with new research to compare the TBC 4 qPCR test with traditional culture.For this study,BTM samples from different TBC intervals were selected based on Bacto Count results found at routine payment investigation at Eurofins laboratory(Vejen,Denmark).These samples were analyzed using TBC 4 qPCR assay within 24 h.In total,346 BTM samples were divided into six different intervals of colony forming units(CFU).For all four targets in each of the different intervals of CFU,the percent of positive samples,the average C_t-value,the percent of positive samples with C_t<30 and C_t<25 were calculated.For Pseudomonas,Streptococci,and Enterobacteriacea/Enterococcus,the number of positive samples with lower C_t-values(high bacteria content)correlated with the CFU mL^(–1).We found Enterobacteriacea/Enterococcus,Pseudomonas,and Streptococci in high number of bacteria(C_t<25)in 25,19 and 56%of samples with CFU mL^(–1) between 50 001–100 000 and 53,44,and 39%in samples with CFU mL^(–1)>100 000.The TBC 4 qPCR test showed to be a strong and fast tool for farmers,advisors and service technicians to address problems with high TBC and ensuring the delivery of good quality milk to the dairy. | Jorgen Katholm Lene Trier Olesen Anders Petersen Snorri Sigurdsson | 2018 | Journal of Integrative Agriculture2018，17，6： | 3 |
| 5 | 连续夺获阈值监测与自动调节起搏器刺激输出——MICRONY SR+起搏器多中心研究显示文摘目的:本研究评价具有心室自动夺获功能的 Microny 起搏器的安全性及功效。方法:自1994年11月至1996年9月欧洲国家的16个医学中心,共有113例植入 Microny 起搏器的患者进入了研究。所有植入的起搏器采用了 Pacesetter 的低极化、双极电极导线(Membrane 1402 T)。患者在出院时及出院后1、3、6、12个月分别进行随访。结果:在植入后1个月的随访中,动态心电图显示所有未夺获的心搏均有后备起搏脉冲(4.5 V/0.49 ms)出现。植入时测试自身 R 波高度为14.7±7.4 mV,刺激除极波高度(ER)为10.2±4.8 mV。这些数值随时间推移保持稳定,但二者无相关性(r=0.29),植入时,由VARIO 功能测试的起搏阈值为0.5±0.2 V,由自动夺获功能测试的阈值为0.6±0.3 V。两种方法测试的起搏阈值在各次随访中相关性较好(r=0.79),平均差异为0.11 V。后备起搏脉冲占起搏刺激的1.1%。发放后备起搏脉冲的原因为未能夺获(7.1%);(伪)融合波(87.0%);ER 感知低下(0.5%)和QRS 感知低下(4.1%)。在自动夺获功能打开时,起搏电流总消耗为1.4 A。结论:本研究证明了自动夺获功能根据当时的起搏阈值安全和可靠地调节起搏器的输出,为患者提供最大的安全性并延长起搏器的使用寿命。 | Malcolm Clarke Bo Liu Hans Schller Ludwig Binner Charles Kennergren Modesto Guerola Peter Weinmann Ole Jorgen Ohm | 1997 | 中华心律失常学杂志1997，1，2： | 2 |
| 6 | Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients显示文摘AIM To investigate if vitamin D deficiency is associated with fatigue in patients with inflammatory bowel disease(IBD).METHODS IBD patients were recruited from nine hospitals in the southeastern and western regions of Norway to participate in a multicenter cross-sectional study lasting from March 2013 to April 2014. Data were collected by interviews, from medical records and laboratory tests. The Fatigue Questionnaire(FQ) was used to measure fatigue. Linear and logistic regression models were applied to explore the possible association between vitamin D deficiency and total fatigue scores and chronic fatigue, respectively. The analyses were adjusted for age, gender, disease activity, depressive symptoms and sleep disturbance.RESULTS In total, 405 patients were included in the analyses, of which 227(56%) had Crohn's disease(CD) and 178(44%) had ulcerative colitis(UC). Vitamin D deficiency(< 50 nmol/L) was present in half(203/405) of the patients. Chronic fatigue was reported by 116(29%) of all included patients with substantial fatigue reported by 194(48%). Vitamin D levels were neither associated with total fatigue nor with chronic fatigue. Higher total fatigue scores and chronic fatigue were both associated with increased disease activity scores in patients with UC and CD, but not with increased CRP or fecal calprotectin. In UC patients, female gender was associated with fatigue in the univariate analysis, but no such difference was found when adjusted for elevated disease activity scores. Sleep disturbance and more depressive symptoms were associated with total fatigue scores in both UC and CD patients, but with chronic fatigue only in CD patients.CONCLUSION In this study, no significant association between fatigue and vitamin D deficiency in IBD patients was revealed. | Svein Oskar Frigstad Marte Lie Hoivik Jorgen Jahnsen Milada Cvancarova Tore Grimstad Ingrid Prytz Berset Gert Huppertz-Hauss Oistein Hovde Tomm Bernklev Bjorn Moum Lars-Petter Jelsness-Jorgensen | 2018 | World Journal of Gastroenterology2018，24，29： | 2 |
| 7 | Lactobacillus plantarum MiLAB 393 produces the antifungal cyclic dipeptides cyclo (L-Phe-L-Pro) and cyclo (L-Phe-trans-4-OH-L-Pro) and 3-phenyllactic acid显示文摘 | Strom K Jorgen S Broberg A | 2002 | Applied and Environment Microbiology2002，68，9： | 1 |
| 8 | Urokinase an activator of plasminogen from human urine 显示文摘 | Jorgen P Niels O K | 1957 | Biochim Biophys Acta1957，，24： | 1 |
| 9 | Disorders of pubertal development显示文摘 | Jorgen B Angelika D | 2009 | Dtsch Arztebl Int2009，106，17： | 1 |
| 10 | Residual effect and leaching of N and K in cropping systems with clover and ryegrass catch crops on a coarse sand显示文摘 | Margrethe Askegaard Jorgen Eriksen | 2008 | Agriculture Ecosystems & Environment2008，123，： | 1 |
| 11 | Strongyloides hyper-infection causing life-threatening gastrointestinal bleeding显示文摘A 55-year old male patient was diagnosed with strongy- loides hyper-infection with stool analysis and intestinal biopsy shortly after his chemotherapy for myeloma. He was commenced on albendazole anthelmintic therapy. After initiation of the treatment he suffered life- threatening gastrointestinal (GI) bleeding. Repeated endoscopies showed diffuse multi-focal intestinal bleeding. The patient required huge amounts of red blood cells and plasma transfusions and correction of haemostasis with recombinant activated factor Ⅶ. Abdominal aorto-angiography showed numerous micro- aneurysms (‘berry aneurysms’) in the superior and inferior mesenteric arteries’ territories. While the biopsy taken prior to the treatment with albendazole did not show evidence of vasculitis, the biopsy taken after initiation of therapy revealed leukoclastic aggregations around the vessels. These findings suggest that, in addition to direct destruction of the mucosa, vasculitis could be an important additive factor causing the massive GI bleeding during the anthelmintic treatment. This might result from substances released by the worms that have been killed with anthelmintic therapy. Current guidelines advise steroids to be tapered and stopped in case of systematic parasitic infections as they might reduce immunity and precipitate parasitic hyper-infection. In our opinion, steroid therapy might be of value in the management of strongyloides hyper- infection related vasculitis, in addition to the anthelmintic treatment. Indeed, steroid therapy of vasculitis with other means of supportive care resulted in cessation of the bleeding and recovery of the patient. | Lajos Csermely Hassan Jaafar Jorgen Kristensen Antonio Castella Waldemar Gorka Ahmed Ali Chebli Fawaz Trab Hussain Alizadeh Béla Hunyady | 2006 | World Journal of Gastroenterology2006，12，39： | 1 |
| 12 | Antifungal 3 - hydroxyfatty acids from Lactobacillus planetarium MiLAB - 14 显示文摘 | Jorgen S Jesper M Anders B | 2003 | Applied and Environmental Microbiology2003，69，12： | 1 |
| 13 | Management of knowledge transfer in knowledge service firms 显示文摘 | Jorgen Hansson | 2002 | Innovative research in management2002，，5： | 1 |
| 14 | Parimutuel betting marketsas infonation aggregation devices:experimental results显示文摘 | Charles R Plott Jorgen Wit Winsron C Yang | | 0，，02： | 1 |
| 15 | Decreased serum testosterone levels in rats exposed intraperitoneally to bismuth subnitrate显示文摘 | Meredin S Allen F Liselotte G S Jorgen R | 2002 | Journal of Applied Toxicology2002，22，2： | 1 |
| 16 | Effect of heavy metals and PAHs on soil assessed via dehydrogenase assay 显示文摘 | Natalya I Jorgen S Valter P | 2003 | Environment Interna- tional2003，28，8： | 1 |
| 17 | Interrup- ting habitual car use: the importantce of car habit strength and moral motivation for personal car use reduction显示文摘 | LOUISE E JORGEN G ANNIKA M N | 2008 | Transportation Research Part F2008，，11： | 1 |
| 18 | Computation of hemodynamics in the circle of Willis显示文摘 | Martin SA Jorgen I Kent -Andre M | 2007 | Stroke2007，38，： | 1 |
| 19 | Determination of water in penicillins using fast Karl Fischer reagents and electronic end-point optimization 显示文摘 | | 1984 | J Pharm Biomed Anal1984，2，1： | 1 |
| 20 | Propagation measurements and models for wireless communications channels显示文摘 | JORGEN A B RAPPAPORT T S YOSHIDA S | 1995 | IEEE Communications Magazien1995，33，1： | 1 |
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