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32篇 您的检索式：作者名="Jong PL"

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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	Outcome after reoperation for atrioventricular septal defect repair显示文摘	Birim O Van Gameren M De Jong PL		0，，01：	1
3	Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction显示文摘	de Jong EC Wierenga EA	2000	J Immunol2000，164，9：	1
4	Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction显示文摘	Vieira PL de Jong EC Wierenga EA	2000	J Immunol2000，164，9：	1
5	Sensitization patterns to food and inhalant allergens in childhood:a comparison of non-sensitized,monosensitized,and polysensitized children显示文摘	De Jong AB Dikkeschei LD Brand PL		0，，02：	1
6	Intraoperative cell salvage in infants undergoing elective cardiac surgery:a prospective trial显示文摘	Golab HD Scohy TV de Jong PL	2008	Eur J Cardiothorac Surg2008，34，2：	1
7	Normal lung function in children with mild to moderate persistent asthma well controlled by inhaled corticosteroids 显示文摘	Baatenburg de Jong A Brouwer AF Roorda R J Brand PL	2006	J Allergy Clin Immunol2006，118，1：	1
8	Development of Th1-inducing capacity in myeloid dendritic cells requires enviromental instruction显示文摘	Vieira PL Jong EC Wierenga EA	2000	J Immunol2000，164，9：	1
9	Cough and malaise in young children due to allergic rhinoconjunctivitis 显示文摘	de Jong AB te Rijdt JP Brand PL	2005	Ned Tijdschr Geneeskd2005，149，28：	1
10	Relevance of colloid oncotic pressure regulation during neonatal and infant cardiopul- monary bypass: a prospective randomized study 显示文摘	Golab HD Seohy TV de Jong PL	2011	Eur J Car- diothorac Surg2011，39，6：	1
11	Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals显示文摘	de Jong EC Vieira PL Kalinski P	2002	J Immunol2002，168，：	1
12	Microbial compounds selectively induced Th1 cellpromoting or Th2 cellpromoting dendritic cells in vitro with diverse Th cell-polarizing signals显示文摘	De Jong EC Vieira PL Kalinski P	2002	J Immunol2002，168，4：	1
13	Relevance of colloid oncotic pressure regulation during neonatal and infant cardiopul- monary bypass: a prospective randomized study 显示文摘	Golab HD Scohy TV de Jong PL	2011	Eur J Car- diothorac Surg2011，39，6：	1
14	Corticosteroids inhibit the production of inflammatory mediators in immature monocyte-derived DC and induce the development of tolerogenic DC3显示文摘	Vieira PL Kalinski P	1999	J Leukoc Biol1999，66，：	1
15	Stilbenes from the roots of Pleuropterus ciliinervis and their antioxidant activities显示文摘	Jong PL Ryung SM Ren BA	2003	Phytochemistry2003，64，5：	1
16	Temporary tricuspid valve detachment in closure of congenital ventricular septal defect显示文摘	Bol Raap G Boge RS AJ De jong PL	1994	Eur J Cardiothorac Surg1994，8，6：	1
17	Long term follow up after surgery in congenitally corrected transposition of the great arteries with a right ventricle in the systemic circulation 显示文摘	Bogers AJ Head SJ de Jong PL	2010	J Cardiothorac Surg2010，5，：	1
18	Predictive value of lymph node metastasis and extracapsular extension for the risk of distant metastases in laryngeal carcinoma显示文摘	Oosterkamp S de Jong JM Van den Ende PL	2006	Laryngoscope2006，116，11：	1
19	Development of Th1-inducing capacity myeloid dendritic cells requires environmental instruction显示文摘	Vieira PL de Jong EC Wierenga EA	2000	J Immunol2000，164，9：	1
20	Stilbenes from the roots of Pleuropterus ciliinervis and their antioxidant activities 显示文摘	Jong PL Byung SM Ren BA	2003	Phytochemistry2003，64，5：	1

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