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| 1 | Magnetic anchor guidance for endoscopic submucosal dissection and other endoscopic procedures显示文摘Endoscopic submucosal dissection(ESD) is a wellestablished, minimally invasive treatment for superficial neoplasms of the gastrointestinal tract. The universal adoption of ESD has been limited by its slow learning curve, long procedure times, and high risk of complications. One technical challenge is the lack of a second hand that can provide traction, as in conventional surgery. Reliable tissue retraction that exposes the submucosal plane of dissection would allow for safer and more efficient dissection. Magnetic anchor guided endoscopic submucosal dissection(MAGESD) has potential benefits compared to other current traction methods. MAG-ESD offers dynamic tissue retraction independent of the endoscope mimicking a surgeon's 'second hand'. Two types of magnets can be used: electromagnets and permanent magnets. In this article we review the MAG-ESD technology, published work and studies of magnets in ESD. We also review the use of magnetic anchor guidance systems in natural orifice transluminal endoscopic surgery and the idea of magnetic non-contact retraction using surface ferromagentization. We discuss the current limitations, the future potential of MAG-ESD and the developments needed for adoption of this technology. | Mohamed Mortagy Neal Mehta Mansour A Parsi Seiichiro Abe Tyler Stevens John J Vargo Yutaka Saito Amit Bhatt | 2017 | World Journal of Gastroenterology2017，23，16： | 12 |
| 2 | Diagnostic and therapeutic direct peroral cholangioscopy using an intraductal anchoring balloon显示文摘AIM:To report our experience using a recently introduced anchoring balloon for diagnostic and therapeutic direct peroral cholangioscopy(DPOC).METHODS:Consecutive patients referred for diagnostic or therapeutic peroral cholangioscopy were evaluated in a prospective cohort study.The patients underwent DPOC using an intraductal anchoring balloon,which was recently introduced to allow consistent access to the biliary tree with an ultraslim upper endoscope.The device was later voluntarily withdrawn from the market by the manufacturer.RESULTS:Fourteen patients underwent DPOC using the anchoring balloon.Biliary access with an ultraslim upper endoscope was accomplished in all 14 patients.In 12(86%) patients,ductal access required sphincteroplasty with a 10-mm dilating balloon.Intraductal placement of the ultraslim upper endoscope allowed satisfactory visualization of the biliary mucosa to the level of the confluence of the right and left hepatic ducts in 13 of 14 patients(93%).Therapeutic interventions by DPOC were successfully completed in all five attempted cases(intraductal biopsy in one and DPOC guided laser lithotripsy in four).Adverse events occurred in a patient on immunosuppressive therapy who developed an intrahepatic biloma at the site of the anchoring balloon.This required hospitalization and antibiotics.Repeat endoscopic retrograde cholangiopancreatography 8 wk after the index procedure showed resolution of the biloma.CONCLUSION:Use of this anchoring balloon allowed consistent access to the biliary tree for performance of diagnostic and therapeutic DPOC distal to the biliary bifurcation. | Mansour A Parsi Tyler Stevens John J Vargo | 2012 | World Journal of Gastroenterology2012，18，30： | 8 |
| 3 | A novel long non-coding RNA Myolinc regulates myogenesis through TDP-43 and Filip1显示文摘 | Giuseppe Militello Mohammed Rabiul Hosen Yuliya Ponomareva Pascal Gellerts Tyler Weirick David John Sajedah Mahmoud Hindi Kamel Mamchaoui Vincent Mouly Claudia Doring Lidan Zhang Miki Nakamura Ashok Kumar So-ichiro Fukada Stefanie Dimmeler Shizuka Uchida | 2018 | Journal of Molecular Cell Biology2018，10，2： | 7 |
| 4 | Histologic and Imaging Features of Mural Nodules in Mucinous Pancreatic Cysts显示文摘 | Ning Zhong Lizhi Zhang Naoki Takahashi Vladislav Shalmiyev Marcia Irene Canto Jonathan E. Clain John C. Deutsch John DeWitt Mohamad A. Eloubeidi Ferga C. Gleeson Michael J. Levy Shawn Mallery Massimo Raimondo Elizabeth Rajan Tyler Stevens Mark Topazian | 2012 | Clinical Gastroenterology and Hepatology2012，，2： | 2 |
| 5 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 6 | DNA origami mediated electrically connected metal–semiconductor junctions显示文摘DNA-based nanofabrication of inorganic nanostructures has potential application in electronics,catalysis,and plasmonics.Previous DNA metallization has generated conductive DNA-assembled nanostructures;however,the use of semiconductors and the development of well-connected nanoscale metal-semiconductor junctions on DNA nanostructures are still at an early stage.Herein,we report the first fabrication of multiple electrically connected metal-semiconductor junctions on individual DNA origami by location-specific binding of gold and tellurium nanorods.Nanorod attachment to DNA origami was via DNA hybridization for Au and by electrostatic interaction for Te.Electroless gold plating was used to create nanoscale metal-semiconductor interfaces by filling the gaps between Au and Te nanorods.Two-point electrical characterization indicated that the Au-Te-Au junctions were electrically connected,with current-voltage properties consistent with a Schottky junction.DNA-based nanofabrication of metal-semiconductor junctions opens up potential opportunities in nanoelectronics,demonstrating the power of this bottom-up approach. | Basu R.Aryal Dulashani R.Ranasinghe Tyler R.Westover Diana G.Calvopia Robert C.Davis John N.Harb Adam T.Woolley | 2020 | Nano Research2020，13，5： | 2 |
| 7 | Clinical outcomes of endoscopic management of pancreatic fluid collections in cirrhotics vs non-cirrhotics: A comparative study显示文摘BACKGROUND Endoscopic management of symptomatic pancreatic fluid collections (PFCs) using self-expandable metal stents (SEMS) placement has emerged as an innovative therapeutic approach with excellent efficacy, safety, and relatively few adverse outcomes. However, their use has not been studied in patients with cirrhosis. Cirrhotics tend to be considered less than optimal candidates due to concern for portal hypertension and coagulopathy related complications. AIM To compare the efficacy and safety of using SEMS for drainage of symptomatic PFCs in cirrhotic vs non-cirrhotic patients. METHODS We conducted a retrospective comparative analysis of patients with symptomatic PFCs [pancreatic pseudocyst (PP) or walled-off necrosis (WON)] who underwent endoscopic ultrasound (EUS)-guided placement of fully covered self-expandable metals stents or lumen-apposing self-expandable metal stents. All patients were followed clinically until resolution of PFCs or death. Definition:(1) Technical success was defined as successful placement of SEMS;and (2) Clinical success was defined as complete resolution of the PFCs without additional interventions including interventional radiology or surgery. Number of procedures performed per patient, number of patients who achieved complete resolution of the PFCs without additional interventions and procedure related adverse events were recorded.RESULTS From January 2012 to December 2017, a total of 88 patients underwent EUSguided drainage of symptomatic PFCs. Of these, 58 non cirrhotic patients underwent plastic stent insertion for management of PFC and 30 patients, 5 with cirrhosis and 25 without cirrhosis, underwent EUS-guided transmural drainage with SEMS, including 18 (60%) PP and 12 (40%) WON. Technical success was achieved in all 30 patients. Clinical success was achieved in 60% cirrhotic patients and 92% non-cirrhotics (P = 0.12). Procedure-related adverse events were 60% in cirrhotic and 28% non-cirrhotic (P = 0.62). Moreover, fatal adverse events were statistically more common in cirrhotics compared with non-cirrhotics (0 vs 40%;P = 0.023). Successful stent removal following resolution of the PFC, was 60% in cirrhotics and 80% in non-cirrhotics (P = 0.57). Post-procedure length of hospitalization was 18.6 ± 20.3 d in cirrhotics and 5.6 ± 13.7 d in non-cirrhotics (P = 0.084). CONCLUSION EUS-guided management of PFC using SEMS placement has a high technical and clinical success rate in non-cirrhotics. However, in cirrhotics caution must be exercised given the high morbidity and mortality as evidenced by our cohort, particularly for the endoscopic debridement of WONs. Larger, multicenter studies are warranted to further characterize the risk profile and outcomes in these patients. | Sobia Laique Matheus C Franco Tyler Stevens Amit Bhatt John J Vargo Prabhleen Chahal | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，6： | 2 |
| 8 | A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response显示文摘 | Maite Huarte Mitchell Guttman David Feldser Manuel Garber Magdalena J. Koziol Daniela Kenzelmann-Broz Ahmad M. Khalil Or Zuk Ido Amit Michal Rabani Laura D. Attardi Aviv Regev Eric S. Lander Tyler Jacks John L. Rinn | 2010 | Cell2010，，3： | 1 |
| 9 | Integrated and passive 1,2,3-triazolyl groups in fluorescent indicators for zinc (Ⅱ) ions:thermodynamic and kinetic evaluations显示文摘 | Tyler J Simmons John R Allen Deborah R Morris | | 0，，： | 1 |
| 10 | Contrast enhancement of medical images using muhiscale decomposition 显示文摘 | Trifas Monica A Tyler John M Pianykh Oleg S | 2006 | Proceedings of SPIE2006，6057，： | 1 |
| 11 | Incidence of radiation pneumonitis after thoracic irradiation: Dose-volume correlates显示文摘 | John M. Schallenkamp Robert C. Miller Debra H. Brinkmann Tyler Foote Yolanda I. Garces | 2007 | International Journal of Radiation Oncology Biology Physics2007，，2： | 1 |
| 12 | Business success factors and innovation in Canadian service sectors: an initial investigation of inter-sectoral differences显示文摘 | Tyler Chamberlin Jerome Doutriaux John Hector | 2010 | The Service Industries Journal2010，，2： | 1 |
| 13 | Florbetapir F-18: A Histopathologically Validated Beta-Amyloid Positron Emission Tomography Imaging Agent显示文摘 | John Lister-James Michael J. Pontecorvo Chris Clark Abhinay D. Joshi Mark A. Mintun Wei Zhang Nathaniel Lim Zhiping Zhuang Geoff Golding Seok Rye Choi Tyler E. Benedum Paul Kennedy Franz Hefti Alan P. Carpenter Hank F. Kung Daniel M. Skovronsky | 2011 | Seminars in Nuclear Medicine2011，，： | 1 |
| 14 | An Evaluation of four different wavelet decomposition procedures for spatial feature discrimination in urban areas显示文摘 | Soe Win Myint Nina Lam John Tyler | 2002 | Transaction in GIS2002，6，4： | 1 |
| 15 | Egg quality in fish: what makes a good egg?显示文摘 | Suzanne Brooks Charles R. Tyler John P. Sumpter | 1997 | Reviews in Fish Biology and Fisheries1997，，4： | 1 |
| 16 | Surgical Treatment of Fixed Cervical Kyphosis With Myelopathy显示文摘 | Brian A. O’Shaughnessy John C. Liu Patrick C. Hsieh Tyler R. Koski Aruna Ganju Stephen L. Ondra | 2008 | Spine2008，，7： | 1 |
| 17 | Multiple effects of silymarin on the hepatitis C virus lifecycle显示文摘 | Jessica Wagoner Amina Negash Olivia J. Kane Laura E. Martinez Yaakov Nahmias Nigel Bourne David M. Owen Joe Grove Claire Brimacombe Jane A. McKeating Eve‐Isabelle Pécheur Tyler N. Graf Nicholas H. Oberlies Volker Lohmann Feng Cao John E. Tavis Stephen J. | 2010 | Hepatology2010，，6： | 1 |
| 18 | A three-wave FDTD approach to surface scattering with application to remote sensing of geophysical surfaces显示文摘 | Wong P B Tyler G L John E B | 1996 | IEEE Trans Antennas and Propagation1996，44，4： | 1 |
| 19 | Concurrent Chemoradiotherapy in Resected Extrahepatic Cholangiocarcinoma显示文摘 | John W. Nelson A. Paiman Ghafoori Christopher G. Willett Douglas S. Tyler Theodore N. Pappas Bryan M. Clary Herbert I. Hurwitz Johanna C. Bendell Michael A. Morse Robert W. Clough Brian G. Czito | 2009 | International Journal of Radiation Oncology Biology Physics2009，，1： | 1 |
| 20 | Pancreatic Cyst: Pseudocyst or Neoplasm? Pitfalls in Endoscopic Retrograde Cholangiopancreatography Diagnosis显示文摘 | Ellis Clayton Tyler Barbour John R Shary Thomas M Adams David B | 2010 | The American Surgeon2010，，7： | 1 |
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