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| 1 | Physical activity, obesity and gastroesophageal reflux disease in the general population显示文摘AIM: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. METHODS: A Swedish population-based cross-sectional survey was conducted. Participants aged 40-79 years were randomly selected from the Swedish Registry of the Total Population. Data on physical activity, GERD, body mass index (BMI) and the covariates age, gender, comorbidity, education, sleeping problems, and tobacco smoking were obtained using validated questionnaires. GERD was self-reported and defined as heartburn or regurgitation at least once weekly, and having at least moderate problems from such symptoms. Frequency of physical activity was categorized into three groups: (1) 'high' (several times/week); (2) 'intermediate' (approximately once weekly); and (3) 'low' (1-3 times/mo or less). Analyses were stratified for participants with 'normal weight' (BMI < 25 kg/m 2 ), 'overweight' (BMI 25 to ≤ 30 kg/m 2 ) and 'obese' (BMI > 30 kg/m 2 ). Multivariate logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounding by covariates. RESULTS: Of 6969 eligible and randomly selected individuals, 4910 (70.5%) participated. High frequency of physical activity was reported by 2463 (50%) participants, GERD was identified in 472 (10%) participants, and obesity was found in 680 (14%). There were 226 (5%) individuals with missing information about BMI. Normal weight, overweight and obese participants were similar regarding distribution of gender and tobacco smoking status, while obese participants were on average slightly older, had fewer years of education, more comorbidity, slightly more sleeping problems, lower frequency of physical activity, and higher occurrence of GERD. Among the 2146 normal-weight participants, crude point estimates indicated a decreased risk of GERD among individuals with high frequency of physical activity (OR: 0.59, 95% CI: 0.39-0.89), compared to low frequency of physical activity. However, after adjustment for potential confounding factors, neither intermediate (OR: 1.30, 95% CI: 0.75-2.26) nor high (OR: 0.99, 95% CI: 0.62-1.60) frequency of physical activity was followed by decreased risk of GERD. Sleeping problems and high comorbidity were identified as potential confounders. Among the 1859 overweight participants, crude point estimates indicated no increased or decreased risk of GERD among individuals with intermediate or high frequency of physical activity, compared to low frequency. After adjustment for confounding, neither intermediate (OR: 0.75, 95% CI: 0.46-1.22) nor high frequency of physical activity were followed by increased or decreased risk of GERD compared to low frequency among nonobese participants. Sleeping problems and high comorbidity were identified as potential confounders for overweight participants. In obese individuals, crude ORs were similar to the adjusted ORs and no particular confounding factors were identified. Intermediate frequency of physical activity was associated with a decreased occurrence of GERD compared to low frequency of physical activity (adjusted OR: 0.41, 95% CI: 0.22-0.77). CONCLUSION: Intermediate frequency of physical activity might decrease the risk of GERD among obese individuals, while no influence of physical activity on GERD was found in non-obese people. | Therese Djrv Anna Wikman Helena Nordenstedt Asif Johar Jesper Lagergren Pernilla Lagergren | 2012 | World Journal of Gastroenterology2012，18，28： | 8 |
| 2 | Causative and preventive action of calcium in cataractogenesis显示文摘Calcium and Ca-dependent enzymes play specifc role in the development of human cataracts. Entry of Ca^2+ into the lens epithelial cells (LEC) is highly regulated by quantum of receptors. The Ca^2+ level controls homeostasis and growth of entire lens. Intracellular overload of Ca^2+ in the LEC trigger a series of events such as activation of Ca-dependent enzymes, irreversible breakdown of important structural proteins and cell death. Proper maintenance of Ca^2+ levels by regulating activity of Ca-pumps and Ca-channels and inhibition of Ca-dependent enzymes can help in prevention of cataract. Induction of cell death in the LEC by increase in the intracellular Ca2~ may be utilized for the prevention of posterior capsular opacification. | Purshottam Das GUPTA Kaid JOHAR Abhay VASAVADA | 2004 | Acta Pharmacologica Sinica2004，25，10： | 5 |
| 3 | Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway显示文摘 | Maddika S Booy EP Johar D | 2005 | J Cell Sci2005，118，19： | 1 |
| 4 | Histomorphological and immunofluorescence evaluation of bimanual and coaxial phacoemulsification incisions in rabbits显示文摘 | Johar SR Vasavada AR Praveen MR Pandita D Nihalani B Patel U et ol | 2008 | J Cataract Refract Surg2008，34，4： | 1 |
| 5 | Market prominence biases in sponsor identification: Processes and consequentiality 显示文摘 | Pham M T Johar G V | 2001 | Psychology & Marketing2001，18，2： | 1 |
| 6 | Relatedness prominence and con- structive sponsor identification显示文摘 | JOHAR G V PHAM M T | 1999 | J Marketing Res1999，36，： | 1 |
| 7 | Effect of hydrodissection alone and hydrodissection combined with rotation on lens epithelial cells:surgical approach for the prevention of posterior capsule opacification显示文摘 | Vasavada AR Raj SM Johar K | | 0，，： | 1 |
| 8 | Aldosterone medi- ates angintensin H -induced interstitial cardiac fibrosis via a Nox2- containing NADPH oxidase 显示文摘 | Johar S Cave A C Narayanapanicker A | 2006 | FASEB J2006，20，9： | 1 |
| 9 | Selif-congruity Versus Functional Congruity: Predictors of Consumer Behavior显示文摘 | Sirgy M J Johar J S Samli A C | 1991 | Jour- nal of the Academy of Marketing Science1991，19，36： | 1 |
| 10 | Relatedness,prominence and constructive sponsor identification显示文摘 | JOHAR PLAM | 1999 | J Marke Res1999，36，3： | 1 |
| 11 | Bigenomic transcriptional regulation of all thirteen cytochrome c oxidase subunit genes by specificity protein 1显示文摘 | DHAR S S JOHAR K WONG-RILEY M T | 2013 | Open Biol2013，3，12： | 1 |
| 12 | Comparative study and optimization of feature extraction techniques for content based image retrieval显示文摘 | Chadha A Mallik S Johar R | 2012 | International Journal of computer application2012，52，20： | 1 |
| 13 | Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2- containing NADPH oxidase显示文摘 | Johar S Cave AC Narayanapanicker A | 2006 | FASEB J2006，20，9： | 1 |
| 14 | Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway显示文摘 | Maddika S Booy EP Johar D etal | 2005 | Cell Sci2005，118，： | 1 |
| 15 | Effect of impurities content from minerals on phase transformation,densifieation and crystallization of a-cordierite glass-ceramics显示文摘 | Banjraizah Johar Mohamad Hasmaliza | 2011 | J Alloys Cornpd2011，509，28： | 1 |
| 16 | Cancer - speci? c toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mi- toehondrial cell - deathmediators by a Nut77 - dependent pathway 显示文摘 | MADDIKA S BOOY E P JOHAR D | 2005 | J Cell Sci2005，8，19： | 1 |
| 17 | Aldosterone mediates angio-tensin Ⅱ-induced interstitial cardiac fibrosis via a NoxⅡ-containing NADPH oxidase显示文摘 | Johar S Cave AC Narayanapanicker A | | 0，，： | 1 |
| 18 | Andrographolide suppresses epithelial mesenchymal transition by inhibition of MAPK signalling pathway in lens epithelial cells显示文摘 | Kayastha F Johar K Gajjar D | 2015 | J Biosci2015，40，2： | 1 |
| 19 | Value - Expressive Versus Utilitarian Advertising Appeals:When and Why to Use Which Appeal显示文摘 | Johar J S Sirgy J | 1991 | Journal of Ad- vertising1991，20，3： | 1 |
| 20 | Content Provision Strategies in the Presence of Content Piracy显示文摘 | Monica Johar Nanda Kumar Vijay Mookerjee | 2012 | Information System Research2012，23，3： | 1 |
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