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| 1 | Predicting early outcomes of liver transplantation in young children: The EARLY study显示文摘AIM To determine potentially modifiable predictors of early outcomes after liver transplantation in children of age < 3 years.METHODS This study was a retrospective chart review including all consecutive children of age less than 3-years-old having had a liver transplant done at the Western Canadian referral center from June 2005 to June 2015.Pre-specified potential predictor variables and primary and secondary outcomes were recorded using standard definitions and a case report form. Associations between potential predictor variables and outcomes were determined using univariate and multiple logistic [odds ratio(OR); 95%CI] or linear(effect size, ES; 95%CI) regressions. RESULTS There were 65 children, of mean age 11.9(SD 7.1) mo and weight 8.5(2.1) kg, with biliary-atresia in 40(62%), who had a living related donor [LRD; 29(45%)], split/reduced [21(32%)] or whole liver graft [15(23%)]. Outcomes after liver transplant included: ventilator-days of 12.5(14.1); pediatric intensive care unit mortality of 5(8%); re-operation in 33(51%), hepatic artery thrombosis(HAT) in 12(19%), portal vein thrombosis(PVT) in 11(17%), and any severe complication(HAT, PVT, bile leak, bowel perforation, intraabdominal infection, retransplant, or death) in 32(49%) patients. Predictors of the prespecified primary outcomes on multiple regression were:(1) HAT: split/reduced(OR 0.06; 0.01, 0.76; P = 0.030) or LRD(OR 0.16; 0.03, 0.95; P = 0.044) vs whole liver graft; and(2) ventilator-days: surgeon(P < 0.05), lowest antithrombin(AT) postoperative day 2-5(ES-0.24;-0.47,-0.02; P = 0.034), and split/reduced(ES-12.5;-21.8,-3.2; P = 0.009) vs whole-liver graft. Predictors of the pre-specified secondary outcomes on multiple regression were:(1) any thrombosis: LRD(OR 0.10; 0.01, 0.71; P = 0.021) or split/reduced(OR 0.10; 0.01, 0.85; P = 0.034) vs whole liver graft, and lowest AT postoperative day 2-5(OR 0.93; 0.87, 0.99; P = 0.038); and(2) any severe complication: surgeon(P < 0.05), lowest AT postoperative day 2-5(OR 0.92; 0.86-0.98; P = 0.016), and split/reduced(OR 0.06; 0.01, 0.78; P = 0.032) vs whole-liver graft. CONCLUSION In young children, whole liver graft and surgeon was associated with more complications, and higher AT postoperative day 2-5 was associated with fewer complications early after liver transplantation. | Rashid Alobaidi Natalie Anton Dominic Cave Elham Khodayari Moez Ari R Joffe | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Validation of computer - assisted manufacture of titanium plates for cranioplasty显示文摘 | Joffe JM Nicoll SR Richards R | 1999 | Int J Oral Maxillofac Surg1999，28，4： | 1 |
| 3 | Drug therapy of the idiopathtic inflammatory myositis:predictors of response to prednisone,azathiopine,and methotrexate and a comparison of their efficacy显示文摘 | Joffe M M Love L A Leff R L | 1993 | Am J Med1993，1994，： | 1 |
| 4 | Validation of computer-assisted manufacture of titanium plates for cranioplasty 显示文摘 | Joffe JM Nicoll SR Richards R et-al | 1999 | Int J-Oral Maxilloface Surg1999，28，4： | 1 |
| 5 | MulticentreValidation of the Bedside Paediatric Early Warning SystemScore: A Severity of Illness Score to Detect Evolving Criti-cal Illness in Hospitalised Children 显示文摘 | Parshuram C S Duncan H P Joffe A R | 2011 | Crit Care2011，15，4： | 1 |
| 6 | Validation of computer-assisted manufacture of titanium plates for cranioplasty 显示文摘 | Joffe JM Nicoll SR Richards R | 1999 | Int J Oral Maxillofac Surg1999，28，4： | 1 |
| 7 | Invited commentary: propensity scores显示文摘 | Joffe M M Rosenbaum P R | 1999 | Am J Epidemiol1999，150，： | 1 |
| 8 | Matrix metalloproteinase expression and activity in isolated myocytes after neurohormonal stimulation显示文摘 | COKER M L JOLLY J R JOFFS C | 2001 | Am J Physiology-Heart & Circulatory Physiol2001，281，： | 1 |
| 9 | Results of unilateral genitofemoral nerve grafts with contralateral nerve sparing during radical rostatectomy 显示文摘 | Joffe R Klotz LH | 2007 | Urology2007，69，6： | 1 |
| 10 | Drug therapy of the idiopathic inflammatory myopathies:predictors of response to prednisone,azathioprine,and methotrexate and a comparison of their efficacy显示文摘 | Joffe M M Love L A Leff R L | 1993 | Am J Med1993，94，4： | 1 |
| 11 | Impact of the fetal fibronectin assay on admissions for preterm labor 显示文摘 | Joffe GM Jacquees D Burton R | 1999 | Am J Obstet Gynecol1999，180，3： | 1 |
| 12 | Impact of eLearning course on nurses' professional competence in seclusion and restraint practices: 9- month follow- up results of a random- ized controlled study (ISRCTN32869544) 显示文摘 | Kontio R H/itbnen H Joffe G | 2013 | J Psychiatr Ment Health Nurs2013，20，5： | 1 |
| 13 | Postoperative lactate concentrations predict the outcome of infants aged 6weeks or less after intracardiac surgery:a cohort follow-up to 18months显示文摘 | CHEUNG P Y CHUI N JOFFE A R | 2005 | J Thorac Cardiovasc Surg2005，130，： | 1 |
| 14 | Impact of the fetal fibronectin assay on admissions for preterm labor显示文摘 | Joffe GM Jacques D Bemis-Heys R | 1999 | Am J Obstet Gynecol1999，180，3： | 1 |
| 15 | Stiffness and strength of flax fiber/polymer matrix composites 显示文摘 | Andersons J Spamins E Joffe R | 2006 | Polymer Composites2006，27，2： | 1 |
| 16 | Impact of the fetal fibronectin assay on admissions for preterm labor 显示文摘 | Joffe G M Jacques D Bemis H R | 1999 | Am J Obstet Gynecol1999，180，： | 1 |
| 17 | Strength and adhesion characteristics of elementary flax fibres with different surface treatments显示文摘 | JOFFE R ANDERSONS J WALLSTROM L | 2003 | Composites Part A:Applied Science and Manufacturing2003，34，7： | 1 |
| 18 | Interracial toughness evaluation from the single-fiber fragmentation test显示文摘 | Varna J Joffe R Berglund L A | 1996 | Composites Science and Technology1996，56，9： | 1 |
| 19 | A global perspective on energy:Health effects and injustices 显示文摘 | WILKINSON P SMITH K R JOFFE M | 2007 | The lancet2007，370，9591： | 1 |
| 20 | Cardiopulmonary bypass induces the synthesis and release of matrix metalloproteinase-2显示文摘 | Joffs C Gunasinghe H R Multani M | 2001 | Ann Thorac Surg2001，71，1： | 1 |
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