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| 1 | Angiogenin and tRNA fragments in Parkinson’s disease and neurodegeneration显示文摘In this review,we summarise the evidence for a role of the ribonuclease angiogenin in the pathophysiology of neurodegenerative disorders,with a specific focus on Parkinson’s disease(PD).Angiogenin is a stress-induced,secreted ribonuclease with both nuclear and cytosolic activities.Loss-of-function mutations in the angiogenin gene(ANG)have been initially discovered in familial cases of amyotrophic lateral sclerosis(ALS),however,variants in ANG have subsequently been identified in PD and Alzheimer’s disease.Delivery of angiogenin protein reduces neurodegeneration and delays disease progression in in vitro and in vivo models of ALS and in vitro models of PD.In the nucleus,angiogenin promotes ribosomal RNA transcription.Under stress conditions,angiogenin also translocates to the cytosol where it cleaves non-coding RNA into RNA fragments,in particular transfer RNAs(tRNAs).Stress-induced tRNA fragments have been proposed to have multiple cellular functions,including inhibition of ribosome biogenesis,inhibition of protein translation and inhibition of apoptosis.We will discuss recent evidence of tRNA fragment accumulation in PD,as well as their potential neuroprotective activities. | Jochen H M Prehn Elisabeth Jirstrom | 2020 | Acta Pharmacologica Sinica2020，41，4： | 2 |
| 2 | Protein engineering of α/β-hydrolase fold enzymes显示文摘 | Jochens H Hesseler M Stiba K | 2011 | Chembiochem2011，12，10： | 1 |
| 3 | Rational assignment of key motifs for function guides in silico enzyme identification显示文摘 | Hohne M Schatzle S Jochens H | 2010 | Nat Chem Biol2010，6，11： | 1 |
| 4 | Safety culture by crm training experiences from 2 trainings and German hospital simulation in healthcare显示文摘 | Wolfgang H Stefan M Jochen V | | 0，，03： | 1 |
| 5 | Analysis of toxic alkaloids in body samples 显示文摘 | JOCHEN B OLAF H D HANS H M | 2009 | Forensic Science International2009，185，： | 1 |
| 6 | Membranes from sulfonated block copolymers for use in fuel cells显示文摘 | Jochen M H Taeger A Vogel C | 2005 | Separation and Purification Technology2005，41，： | 1 |
| 7 | 显示文摘 | Jochen M H Lenk W Lehmann D | 2001 | J Membr Sci2001，184，2： | 1 |
| 8 | Pervaporation separation of water/alcohol mixtures using composite membranes based on polyelectrolyte multilayer assemblies显示文摘 | Jochen M H Lenk W Lehmann D | 2001 | Journal of Membrane Science2001，184，23： | 1 |
| 9 | 显示文摘 | Jochen H Andrei V M Herman J B | 2003 | Jpn J Appl Phys2003，42，： | 1 |
| 10 | Sulphonated poly(ether ether ketone) copolymers: Synthesis, characterisation and membrane properties显示文摘 | Lakshmi M R T S Jochen M H Schlenstedt K | 2005 | Journal of Membrane Science2005，261，： | 1 |
| 11 | Pervaporation separation of water/alcobol mixtures using composite membranes based on polyelectrolyte multilayer assemblies显示文摘 | Jochen M H Lenk W Lehmann D | 2001 | Journal of Membrane Science2001，184，： | 1 |
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