|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Accuracy of triage strategies for human papillomavirus DNA-positive women in low-resource settings:A cross-sectional study in China显示文摘Objective: Care HPV is a human papillomavirus(HPV) DNA test for low-resource settings(LRS).This study assesses optimum triage strategies for care HPV-positive women in LRS.Methods: A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid(VIA),liquid-based cytology and HPV testing by physician-and self-collected care HPV,and physician-collected Hybrid Capture 2(HC2).Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary.HPV-positivity was defined as ≥1.0 relative light units/cutoff(RLU/CO) for both care HPV and HC2.Primary physician-HC2,physician-care HPV and self-care HPV and in sequential screening with cytology,VIA,or increased HPV test-positivity performance,stratified by age,were assessed for cervical intraepithelial neoplasia(CIN) grade 2/3 or worse(CIN2/3+) detection.Results: The sensitivities and specificities of primary HPV testing for CIN2+ were: 83.8%,88.1% for physiciancare HPV; 72.1%,88.2% for self-care HPV; and 97.1%,86.0% for HC2.Physician-care HPV test-positive women with VIA triage had a sensitivity of 30.9% for CIN2+ versus 80.9% with cytology triage.Self-care HPV testpositive women with VIA triage was 26.5% versus 66.2% with cytology triage.The sensitivity of HC2 test-positive women with VIA triage was 38.2% versus 92.6% with cytology triage.The sensitivity of physician-care HPV testing for CIN2+ decreased from 83.8% at ≥1.0 RLU/CO to 72.1% at ≥10.00 RLU/CO,while the sensitivity of selfcare HPV testing decreased from 72.1% at ≥1.0 RLU/CO to 32.4% at ≥10.00 RLU/CO; similar trends were seen with age-stratification.Conclusions: VIA and cytology triage improved specificity for CIN2/3 than no triage.Sensitivity with VIA triage was unsuitable for a mass-screening program.VIA provider training might improve this strategy.Cytology triage could be feasible where a high-quality cytology program exists.Triage of HPV test-positive women by increased test positivity cutoff adds another LRS triage option. | Margaret Wang Shangying Hu Shuang Zha o Wenhua Zhang Qinjing Pan Xun Zhang FengChen Jinxiu Han Junfei Ma Jennifer S.Smith Youlin Qiao Caihong Zhou Fanghui Zhao | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 2 | Mesenchymal stromal/stem cells:breaking the deadlock in the treatment of multiple organ dysfunction syndrome显示文摘Multiple organ dysfunction syndrome(MODS)is a clinical syndrome characterized by the dysfunction of two or more systems or organs.This internal environment disorder occurs simultaneously 24 h after severe trauma,shock,or infection.MODS has a high fatality rate ranging from 20%to 100%.[1]In the development of MODS following severe trauma or infection,multiple organ system fail sequentially,involving the lungs,kidneys,liver,cardiovascular,central nervous system,gastrointestinal,immune,and the blood coagulation system.MODS has complex pathogenic factors,and there are four main pathogenesis hypotheses:(1)uncontrolled inflammation hypothesis,(2)ischemia–reperfusion injury,(3)the gastrointestinal hypothesis,and(4)the biphasic preexcitation theory.Although the current clinical treatment methods of MODS,such as inflammatory factor antibodies,highly effective anti-coagulants,renal function replacement therapy,and other treatment methods,have been improved continuously,their effectiveness in MODS treatment is not ideal.Therefore,clinical MODS treatment is faced with great challenges[Figure 1]. | Jinxiu Hu Ye Li Jie He Xiaojuan Zhao Mengdie Chen Li Ye Xinghua Pan | 2022 | Chinese Medical Journal2022，135，23： | 0 |
| 3 | Fluoro-ruby retrograde tracing and three-dimensional visualization of the corticospinal tract in the guinea pig显示文摘Fluoro-ruby was injected into the posterior funiculus of the spinal cord in the cervical(C5-T2) and lumbar(L3-6) segments of adult guinea pigs.The spinal cord was cut into serial frozen sections.The Fluoro-ruby labeling was clearly delineated from the surrounding structure.The labeling traversed the cervical,thoracic and lumbar segments,and was located on the ventral portion of the posterior funiculus on the injected side,proximal to the intermediate zone of the dorsal gray matter.The fluorescence area narrowed rostro-caudally.The spinal cord,spinal cord gray matter and corticospinal tract were reconstructed using 3D-DOCTOR 4.0 software,resulting in a robust three-dimensional profile.Using functionality provided by the reconstruction software,free multi-angle observation and sectioning could be conducted on the spinal cord and corticospinal tract.Our experimental findings indicate that the Fluoro-ruby retrograde fluorescent tracing technique can accurately display the anatomical location of corticospinal tract in the guinea pig and that three-dimensional reconstruction software can be used to provide a three-dimensional image of the corticospinal tract. | Xiao Han Lulian Xu Yue Wu Hua Xun Jinxiu Pan Yingying Huang Dafeng Ji Huiqun Wu Guangming Lv Lemin Tang | 2012 | Neural Regeneration Research2012，7，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员