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| 1 | Programmed Death Ligand-1 on Microglia Regulates Th1 Differentiation via Nitric Oxide in Experimental Autoimmune Encephalomyelitis显示文摘Microglia are considered to be potential antigen-presenting cells and have the ability to present antigen under pathological conditions. Nevertheless, whether and how microglia are involved in immune regulation are largely unknown. Here, we investigated the suppressive activity of microglia during experimental autoimmune encephalomyelitis(EAE) induced by myelin oligodendrocyte glycoprotein, with the goal of understanding their role in regulating the T cell reaction. Using flow cytometric analysis, we found that microglia were characterized by increased cell number and up-regulated programmed death ligand-1(PD-L1) at the peak phase of EAE. Meanwhile,both the CD^(4+)T cells and microglia that infiltrated the central nervous system expressed higher levels of PD1, the receptor for PD-L1, accompanied by a decline of Th1 cells.In an ex vivo co-culture system, microglia from EAE mice inhibited the proliferation of antigen-specific CD^(4+)T cells and the differentiation of Th1 cells, and this was significantly inhibited by PD-L1 blockade. Further,microglia suppressed Th1 cells via nitric oxide(NO), the production of which was dependent on PD-L1. Thus, these data suggest a scenario in which microglia are involved in the regulation of EAE by suppressing Th1-cell differentiation via the PD-L1-NO pathway. | Jingxia Hu Hao He Zhengang Yang Guangming Zhu Li Kang Xiuli Jing Hai Lu Wengang Song Bo Bai Hua Tang | 2016 | Neuroscience Bulletin2016，32，1： | 9 |
| 2 | Re-isolation of Wuxiang Virus from Wild Sandflies Collected from Yangquan County, China显示文摘We previously isolated a new species of the genus Phlebovirus from wild sandflies collected from Wuxiang County in central China,which named the Wuxiang virus(WUXV).In this study,we re-isolated the WUXV from wild sandflies collected from two villages in Yangquan County,China in 2019.Four virus isolates that caused cytopathic effects in BHK-21 cells were successfully isolated from sandfly specimens collected from chicken pens and sheep pens.Phylogenetic analyses of the L,M and S gene segments of the viruses revealed that the four virus strains represented the previously isolated WUXV.The minimum infection rate(MIR)of the virus isolated from the sheep pen was 3.21,and the MIR of the virus isolated from the chicken pen was 3.45.The positive rates of Wuxiang virus neutralizing antibodies in serum samples of local healthy people and domestic chickens were 8.7%(4/46)and 100%(4/4),respectively,suggesting that Wuxiang virus can infect human and animal.In view of the fact that Wuxiang virus is infectious to humans and animals and has a relatively wide geographical distribution in China,it is of great public health significance to strengthen the investigation and study on the infection status of Wuxiang virus in humans and animals. | Qinyan Wang Shihong Fu Jingxia Cheng Xiuyan Xu Jing Wang Bin Wu Xiaodong Tian Yan Li Ying He Fan Li Kai Nie Songtao Xu Bin Wang Huanyu Wang Xiaoqing Lu Guodong Liang | 2021 | Virologica Sinica2021，36，5： | 4 |
| 3 | Discovery and biosynthesis of thioviridamide-like compounds显示文摘Thioviridamide-like compounds are a unique subfamily of ribosomally synthesized and post-translationally modified peptides and contain characteristic thioamide bonds and S-[(Z)-2-aminovinyI]-Dcysteine(AviCys). Members of this family are active against a number of cancer cell lines. The distribution, biosynthetic machinery and the mode of action of thioviridamide-like compounds remain largely unknown. In this review, we outlined recent advances in the discovery of thioviridamide-like peptide natural products and the effort in the elucidation of their biosynthetic origin. | Jian Tang Jingxia Lu Qunfeng Luo Huan Wang | 2018 | Chinese Chemical Letters2018，29，7： | 1 |
| 4 | Determination of Inorganic Element Concentrations in the Roots of Plumbago zeylanica L.显示文摘 | Jingxia Wang Ling Ding Yunzhang Xu Xiaoyan Zhao Mei Sun Yuan Liu Jizhong Zhang Zhifeng Zhang Luyang Lu | 2014 | Analytical Letters2014，，5： | 1 |
| 5 | Development in Conducting Bus of RE-Al Alloys显示文摘Four kinds of deformed aluminum alloys were tested. One kind of RE-Al-Mg-Si alloy, which possessed high conductivity and strength, was the first priority by contrast test. The large specification bus of conducting aluminum all- oys was made by thermomechanical process during the industrial experiment. The properties of the bus are as follows: the tensile strength at is 238 MPa, the conductivity (v.s. IACS) is 54.3%, and the current-carrying capacity is beyond 3.1 kA during working process. This kind of RE-Al alloy bus has been applied to several electrical transmitting and trans- forming work. | Jizhou Wang, Jingxia Li, Lu Shi, Zhenzhong Tai (Material and Metallurgical College, Northeastern University, Shopna 110015, China Shenyang ASTRON Mining Ltd. Corp., Shenyang 110003, China) | 2001 | Rare Metals2001，20，2： | 1 |
| 6 | Application of Variable Strategies in the Low-cost and Energy-saving Rural Residences in Transitional Areas显示文摘Changeful and complex rural family structure and climatic features of transitional areas in China make the application of variable strategy in energy-saving rural residence designs possible.Aiming at the low cost,several effective and reasonable variable strategies were proposed for the design of interior spaces,main bedroom,sunshine room,staircase,west wall,door and window design to satisfy changing structure of a family during different periods and their different thermo-technical requirements in winter and summer.In this way,thermal comfort of rural indoor spaces will be improved,more energy saved,useful experience and thoughts provided for the energy-saving residence design in cold regions and regions hot in summer and cold in winter. | LU Meijun LIU Jingxia WANG Guixiu | 2012 | Journal of Landscape Research2012，4，9： | 1 |
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