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| 1 | Biomass-Based Rice (Oryza sativa L.) Aboveground Architectural Parameter Models显示文摘To quantify the relationships between rice plant architecture parameters and the corresponding organ biomass, and to research on functional structural plant models of rice plant, this paper presented a biomass-based model of aboveground architectural parameters of rice (Oryza sativa L.) in the young seedling stage, designed to explain effects of cultivars and environmental conditions on rice aboveground morphogenesis at the individual leaf level. Various model variables, including biomass of blade and blade length, were parameterized for rice based on data derived from an outdoor experiment with rice cv. Liangyou 108, 86You 8, Nanjing 43, and Yangdao 6. The organ dimensions of rice aboveground were modelled taking corresponding organ biomass as an independent variable. Various variables in rice showed marked consistency in observation and simulation, suggesting possibilities for a general rice architectural model in the young seedling stage. Our descriptive model was suitable for our objective. However, they can set the stage for connection to physiological model via biomass and development of functional structural rice models (FSRM), and start with the localized production and partitioning of assimilates as affected by abiotic growth factors. The finding of biomass-based rice architectural parameter models also can be used in morphological models of blade, sheath, and tiller of the other stages in rice life. | CAO Hong-xin LIU Yan LIU Yong-xia Jim Scott Hanan YUE Yan-bin ZHU Da-wei LU Jian-fei SUN Jin-ying SHI Chun-lin GE Dao-kuo WEI Xiu-fang YAO An-qing TIAN Ping-ping BAO Tai-lin | 2012 | Journal of Integrative Agriculture2012，11，10： | 11 |
| 2 | Evolving role of biomaterials in diagnostic and therapeutic radiation oncology显示文摘Radiation therapy to treat cancer has evolved significantly since the discovery of x-rays.Yet,radiation therapy still has room for improvement in reducing side effects and improving control of cancer.Safer and more effective delivery of radiation has led us to novel techniques and use of biomaterials.Biomaterials in combination with radiation and chemotherapy have started to appear in pre-clinical explorations and clinical applications,with many more on the horizon.Biomaterials have revolutionized the field of diagnostic imaging,and now are being cultivated into the field of theranostics,combination therapy,and tissue protection.This review summarizes recent development of biomaterials in radiation therapy in several application areas. | Siyu Shi Ravi Vissapragada Joseph Abi Jaoude Caroline Huang Anmol Mittal Elisa Liu Jim Zhong Vivek Kumar | 2020 | Bioactive Materials2020，5，2： | 4 |
| 3 | Impact of diabetes on promoting the growth of breast cancer显示文摘Background:Type Ⅱ diabetes mellitus(DM2)is a significant risk factor for cancers,including breast cancer.However,a proper diabetic breast cancer mouse model is notwell-established for treatment strategy design.Additionally,the precise diabetic signaling pathways that regulate cancer growth remain unresolved.In the present study,we established a suitable mouse model and demonstrated the pathogenic role of diabetes on breast cancer progression.Methods:We successfully generated a transgenic mouse model of human epidermal growth factor receptor 2 positive(Her2^(+) or ERBB2)breast cancer with DM2 by crossing leptin receptor mutant(Lepr^(db/+))mice with (MMTV-ErbB2/neu)mice.Themousemodelswere administrated with antidiabetic drugs to assess the impacts of controlling DM2 in affecting tumor growth.Magnetic resonance spectroscopic imaging was employed to analyze the tumor metabolism.Results:Treatment with metformin/rosiglitazone in MMTV-ErbB2/Lepr^(db/db) mousemodel reduced serum insulin levels,prolonged overall survival,decreased cumulative tumor incidence,and inhibited tumor progression.Anti-insulin resistance medications also inhibited glycolytic metabolism in tumors in vivo as indicated by the reduced metabolic flux of hyperpolarized ^(13)C pyruvate-to-lactate reaction.The tumor cells from MMTV-ErbB2/Lepr^(db/db) transgenic mice treated with metformin had reprogrammed metabolism by reducing levels of both oxygen consumption and lactate production.Metformin decreased the expression of Myc and pyruvate kinase isozyme 2(PKM2),leading to metabolism reprogramming.Moreover,metformin attenuated the mTOR/AKT signaling pathway and altered adipokine profiles.Conclusions:MMTV-ErbB2/Lepr^(db/db) mouse model was able to recapitulate diabetic HER2^(+) human breast cancer.Additionally,our results defined the signaling pathways deregulated in HER2^(+) breast cancer under diabetic condition,which can be intervened by anti-insulin resistance therapy. | Ping-Chieh Chou Hyun Ho Choi Yizhi Huang Enrique Fuentes-Mattei Guermarie Velazquez-Torres Fanmao Zhang Liem Phan Jaehyuk Lee Yanxia Shi James A.Bankson Yun Wu Huamin Wang Ruiying Zhao Sai-Ching Jim Yeung Mong-Hong Lee | 2021 | Cancer Communications2021，41，5： | 4 |
| 4 | Comparison of Crop Model Validation Methods显示文摘In this paper, the many indices used in validation of crop models, such as RMSE (root mean square errors), Sd (standard error of absolute difference), da (mean absolute difference), dap (ratio of da to the mean observation), r (correlation), and R2 (determination coefficient), are compared for the same rice architectural parameter model, and their advantages and disadvantages are analyzed. A new index for validation of crop models, dap between the observed and the simulated values, is proposed, with dap<5% as the suggested standard for precision of crop models. The different kinds of validation methods in crop models should be combined in the following aspects:(1) calculating da and dap; (2) calculating the RMSE or Sd; (3) calculating r and R2, at the same time, plotting 1:1 diagram. | CAO Hong-xin Jim Scott Hanan LIU Yan LIU Yong-xia YUE Yan-bin ZHU Da-wei LU Jian- fei SUNJin-ying SHI Chun-lin GE Dao-kuo WEI Xiu-fang YAO An-qing TIAN Ping-ping BAO Tai-lin | 2012 | Journal of Integrative Agriculture2012，11，8： | 3 |
| 5 | Preparation, luminescence and sintering properties of Ce-doped BaHfO3 phosphors显示文摘 | JIM Y JIANG D Y CHEN J J QIN L S XU Y P FENG T SHI J L | 2006 | Optical Materials2006，28，： | 1 |
| 6 | New cements for the 21st century:The pursuit of an alternative to Portland cement显示文摘 | Shi C J Jiménez A F Palomo A A | 2011 | Cement and Concrete Research2011，41，7： | 1 |
| 7 | Landscape ecological assessment of green space fragmentation in Hong Kong显示文摘 | Yuhong Tian C.Y. Jim Yan Tao Tao Shi | 2011 | Urban Forestry & Urban Greening2011，，2： | 1 |
| 8 | New Cements for the 21st Century:The Pursuit of an Alternative to Portland Cement显示文摘 | Palomo A Shi C Jiménez A F | 2011 | Cem Concr Res2011，41，7： | 1 |
| 9 | New cements for the 21st century: The pursuit of an alternative to Portland cement 显示文摘 | SHI C FERNáNDEZ JIMéNEZ A PALOMO A | 2011 | Cem Concr Res2011，41，75： | 1 |
| 10 | Computer Chinese chese显示文摘 | Shi -Jim Yen Jr-vhang chen Shun -chin Hsu | 2004 | ICCA Journal2004，，3： | 1 |
| 11 | Introduction to carbon nanotube and nanofiber smart materials显示文摘 | Inpil Kang Yun Yeo Heung Jay H. Kim Jong Won Lee Ramanand Gollapudi Srinivas Subramaniam Suhasini Narasimhadevara Douglas Hurd Goutham R. Kirikera Vesselin Shanov Mark J. Schulz Donglu Shi Jim Boerio Shankar Mall Marina Ruggles-Wren | 2006 | Composites Part B2006，，6： | 1 |
| 12 | New Cements for the 21st Century:The Pursuit of an Alternative to Portland Cement显示文摘 | Shi C Jiménez AF Palomo A | 2011 | Cement and Concrete Research2011，41，7： | 1 |
| 13 | New cements for the 21st century: The pursuit of an alternative to Portland cement显示文摘 | Caijun Shi A. Fernández Jiménez Angel Palomo | 2011 | Cement and Concrete Research2011，，7： | 1 |
| 14 | Ferrocene-func- tionalized hyperbranched polyphenylenes: synthesis, redox activity, light refraction, transition-metal compl exation, and precursors to magnetic ceramics显示文摘 | Shi J B Jim C J W Mahtab F | 2010 | Mac- romolecules2010，43，2： | 1 |
| 15 | Computer Chinese Chess显示文摘 | Yen Shi - Jim Chen Jr - Chang Yang Tai - Ning | 2004 | ICGA Journal2004，，3： | 1 |
| 16 | Spatial distribution and network morphology of epicardial,endocardial,interstitial,and Purkinje cell-associated elastin fibers in porcine left ventricle显示文摘Cardiac extracellular matrices(ECM)play crucial functional roles in cardiac biomechanics.Previous studies have mainly focused on collagen,the major structural ECM in heart wall.The role of elastin in cardiac mechanics,however,is poorly understood.In this study,we investigated the spatial distribution and microstructural morphologies of cardiac elastin in porcine left ventricles.We demonstrated that the epicardial elastin network had location-and depth-dependency,and the overall epicardial elastin fiber mapping showed certain correlation with the helical heart muscle fiber architecture.When compared to the epicardial layer,the endocardial layer was thicker and has a higher elastin-collagen ratio and a denser elastin fiber network;moreover,the endocardial elastin fibers were finer and more wavy than the epicardial elastin fibers,all suggesting various interface mechanics.The myocardial interstitial elastin fibers co-exist with the perimysial collagen to bind the cardiomyocyte bundles;some of the interstitial elastin fibers showed a locally aligned,hinge-like structure to connect the adjacent cardiomyocyte bundles.This collagen-elastin combination reflects an optimal design in which the collagen provides mechanical strength and elastin fibers facilitate recoiling during systole.Moreover,cardiac elastin fibers,along with collagen network,closely associated with the Purkinje cells,indicating that this ECM association could be essential in organizing cardiac Purkinje cells into“fibrous”and“branching”morphologies and serving as a protective feature when Purkinje fibers experience large deformations in vivo.In short,our observations provide a structural basis for future in-depth biomechanical investigations and biomimicking of this long-overlooked cardiac ECM component. | Xiaodan Shi Song Zhang Yue Liu Bryn Brazile Jim Cooley J.Ryan Butler Sara R.McMahan Karla L.Perez Jiazhu Xu Timothy Eastep Kytai T.Nguyen Pietro Bajona Matthias Peltz Huajian Gao Yi Hong Jun Liao | 2023 | Bioactive Materials2023，，1： | 0 |
| 17 | 拍卖行化身多元艺术空间——嘉德艺术中心显示文摘嘉德艺术中心紧邻紫禁城,作为一座全新的综合文化机构,将北京的古城韵味与现代大都会的蓬勃生机以及多元艺术融为一体.嘉德艺术中心是世界上第一个量身定制的拍卖行总部,在北京的中心创建了一个全新的多元艺术机构类型.建筑提供博物馆硬件质量的展示空间和最先进的艺术品保护设施,同时也是一个灵活丰富的文化空间,与餐馆、酒店、公共交通基础设施结合在一起. | Marcel Holmberg Sun Ke Emily Liang Cecilia Lei Yingda Ahrens Mark Biemans Kim Bjarke Catarina Canas Alicia Casals Michael Cavander Jeffrey Cheng Patrick Conway Dyno Du Nicolaz Frez Brian Fung Daniel Hawkins Xinran Ji Philipp Kramer Emeline Laurencon Yuyang Lin Mavis Liu Wymen Lo Max Ma Rafael Merino John Murphey Marcin Olszowski Kevin Ou Kevin Park Yanyadech Phornphong Aaron Powers Klementina Savickaite Jim Shi Chiara Storino Joseph Tang Yang Tao Elena Yang Quentin Yiu Francis Young Lei Yu Danny Zhang Bruno Zhao Weiwei Zhang Yi Zhu Catarina Canas Brian Fung Paloma Hernaiz Marcel Holmberg Tait Kaplan Jaime Oliver Joseph Tang | 2018 | 设计家2018，，1： | 0 |
| 18 | 糖尿病对促进乳腺癌生长的影响显示文摘背景与目的2型糖尿病(typeⅡdiabetes mellitus,DM2)是包括乳腺癌在内的多种癌症的危险因素。目前,尚未建立可用于研究的糖尿病乳腺癌小鼠模型。另外,调节癌症生长的糖尿病信号通路也尚未明确。在本研究中,我们建立了一个糖尿病乳腺癌小鼠模型,并证实了糖尿病在乳腺癌进展中的影响。方法通过将瘦素受体突变(Lepr^(db/+))小鼠和MMTV-ErbB2/neu小鼠杂交,成功构建了人表皮生长因子受体2阳性(human epidermal growth factor receptor 2,Her2^(+)或ERBB2)的乳腺癌转基因小鼠模型。用抗糖尿病药物治疗该小鼠模型来评价治疗DM2对肿瘤生长的影响。用磁共振波谱成像分析肿瘤代谢情况。结果用二甲双胍/罗格列酮治疗MMTV-ErbB2/Lepr^(db/db)小鼠模型可降低血清胰岛素水平,延长生存,降低肿瘤累积发生率,抑制肿瘤进展。超极化^(13)C标记的丙酮酸/乳酸转换代谢流降低,表明抗胰岛素抵抗治疗抑制了体内实验中肿瘤糖酵解。用二甲双胍处理MMTV-ErbB2/Lepr^(db/db)转基因小鼠来源的肿瘤细胞,降低了耗氧量和乳酸产量,使细胞代谢发生了重新编程。二甲双胍可降低Myc和丙酮酸激酶M2型同工酶(pyruvate kinase isozyme 2,PKM2)的表达,引起代谢重编程。另外,二甲双胍可阻断mTOR/AKT信号通路并改变脂肪因子谱。结论MMTV-ErbB2/Lepr^(db/db)转基因小鼠模型可用于糖尿病HER2^(+)人乳腺癌的研究。本研究明确了糖尿病状态下HER2^(+)人乳腺癌中失调的信号通路,该通路可被抗胰岛素抵抗治疗干预。 | Ping-Chieh Chou Hyun Ho Choi Yizhi Huang Enrique Fuentes-Mattei Guermarie Velazquez-Torres Fanmao Zhang Liem Phan Jaehyuk Lee Yanxia Shi James A.Bankson Yun Wu Huamin Wang Ruiying Zhao Sai-Ching Jim Yeung Mong-Hong Lee | 2022 | 癌症2022，41，3： | 0 |
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