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| 1 | Function and regulation of cholecystokinin-octapeptide, β-endorphin and gastrin in anorexic infantile rats treated with ErBao Granules显示文摘AIM To study the role of cholecystokinin octapeptide ( CCK-8), β-endorphin ( β-EP), and gastrin in an anorexic infantile rat model and no subsequent regulation of nose peptides by the Yunpi complex prescription ErBao Granule.METHODS We fed infantile rats with special prepared forage. A liquid extract of ErBao Granule was administered to the rats daily for 3weeks, CCK-8, β-EP, and gastrin concentrations in hypothalamus, gastric antrum, and plasma of the rats were measured by radioimmunoassay,and were compared with controls.RESULTS Treatment of rats with ErBao Granule inhibited CCK-8 secretion and increased β-EP and gastrin secretion. CCK-8 concentration in hypothalamus and plasma of model control group increased significantly and correlated negatively with food intake of models.respectively. β-EP concentration in gastric antrum and plasma of model control group decreased significantly and showed a positive correlation with food intake of models,respectively. Hypothalamus concentration of β-EP was similar in models and controls. Gastrin concentration in gastric antrum of models was lower than in the blank control group, and correlated positively to food intake of models.Finally, CCK-8 concentrations in plasma of rats showed a positive correlation with plasma β-EP(r- 0.68, P<0.05).CONCLUSION The increased plasma and hypothalamus concentration of CCK-8,decreased gastric antrum and plasma level of β-EP. and decreased gastric antrum concentration of gastrin are associated significantly with the anorexia of infantile anorexic rat models produced by special forage. ErBao Granule can reverse these changes, which may be the major mechanisms of ErBao Granule simulating feeding. | Yong Ping Du1 Yue Ping Zhang2 Shou Chuan Wang3 Jian Shi1 Shao Hua Wu1,1.Department of Traditional Chinese Medicine. Xijing Hospital, theFourth Military Medical University. Xi an 7101132, Shaanxi Province,China 2.Department of Pediatrics. Xijing Hospital, the Fourth Military MedicalUniversity. Xi’an 710032. Shaanxi Province. China 3.Department of Pediatrics. Nanjing University of Traditional ChineseMedicine, Nanjing71011?l, Jiangsu Province. China | 2001 | World Journal of Gastroenterology2001，7，2： | 14 |
| 2 | A Phenolic Glucoside from Alangium plantanifolium显示文摘A novel phenolic glucoside was isolated from stem barks of Alangium plantanifolium, its structure was elucidated to be 1-O-[2-(1-hydroxy-6-oxocyclohex-2-ene-1-carboxymethyl) -phenyl]-4, 6-O-[(S)-4, 4(, 5, 5(, 6, 6(-hexahydroxydi-phenoyl]-(-D-glucopyranose 1 by spectroscopic methods including 2D NMR techniques. | Wen Yan HU1, Wen Ping XU2, Jian Gong SHI1*, Yong Chun YANG1, Guang Xiong ZHOU1 1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing 100050 2Hospital of Jiu Quan District, Gansu Province, Jiuquan Dis | 2001 | Chinese Chemical Letters2001，12，9： | 0 |
| 3 | A New Bianthraqinonc Glycoside from Eremurus chinensis显示文摘A new bianthraquinone glycoside, 8-O-β-D-glucopyranosyl-2,7’-bi(1,8-dihydroxy-3- methyl-9, 10-anthraquinonyl)1 was isolated from Eremurus chinensis Fedtch. Its structure was established by spectroscopic techniques including 2D-NMR and chemical methods. | Jian Gong SHI1 Chong LI2 Ying Peng ZHANG2 Cheng Zhong ZHANG2 (1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical, College, Beijing, 100050 2Department of Pharmacy, Lanzhou Medical College, Lanzhou 730000) | 2000 | Chinese Chemical Letters2000，11，2： | 0 |
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