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| 1 | Herbal decoctosome is a novel form of medicine显示文摘Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy. | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao DANDan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 26 |
| 2 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 3 | Microfluidic Generation of Microsprings with Ionic Liquid Encapsulation for Flexible Electronics显示文摘Inspired by helical or spiral veins,which endow plants with excellent fexibility and elasticity to withstand storms,we present novel hollow microsprings with ionic liquid encapsulation for fexible and stretchable electronics.Te microsprings were generated by using a coaxial capillary microfuidic device to consecutively spin poly(vinylidene fuoride)(PVDF)presolution and an ionic liquid,which formed laminar fows in the coaxial injection microfuidic channels.Te fast phase inversion of PVDF helps to form the core-shell structure of a microfber and guarantees the in situ encapsulation of ionic liquid.Te hybrid microfber can then spiral and be further solidifed to maintain the helical structure with increasing fow rates of the injection fuids.Because of the feasible and precise control of the injection fuids during the microfuidic spinning,the resultant microsprings have controlled core-shell structures,helical pitches,and corresponding electromechanical properties.By further embedding them into stretchable flms,the simple paradigm of a fexible device shows great conductive performance in tensile tests and even motion cycles,which could be explored as a promising candidate in stretchable sensors,fexible electronics,and electronic skins. | Yunru Yu Jiahui Guo Lingyu Sun Xiaoxuan Zhang Yuanjin Zhao | 2019 | Research2019，，1： | 14 |
| 4 | Morphological Hydrogel Microfibers with MXene Encapsulation for Electronic Skin显示文摘Electronic skins with distinctive features have attracted remarkable attention from researchers because of their promising applications in flexible electronics.Here,we present novel morphologically conductive hydrogel microfibers with MXene encapsulation by using a multi-injection coflow glass capillary microfluidic chip.The coaxial flows in microchannels together with fast gelation between alginate and calcium ions ensure the formation of hollow straight as well as helical microfibers and guarantee the in situ encapsulation of MXene.The resultant hollow straight and helical MXene hydrogel microfibers were with highly controllable morphologies and package features.Benefiting from the easy manipulation of the microfluidics,the structure compositions and the sizes of MXene hydrogel microfibers could be easily tailored by varying different flow rates.It was demonstrated that these morphologically conductive MXene hydrogel microfibers were with outstanding capabilities of sensitive responses to motion and photothermal stimulations,according to their corresponding resistance changes.Thus,we believe that our morphologically conductive MXene hydrogel microfibers with these excellent features will find important applications in smart flexible electronics especially electronic skins. | Jiahui Guo Yunru Yu Dagan Zhang Han Zhang Yuanjin Zhao | 2021 | Research2021，，1： | 12 |
| 5 | Efficient allelic replacement in rice by gene editing: A case study of the NRT1.1B gene显示文摘Precise replacement of an existing allele in commercial cultivars with an elite allele is a major goal in crop breeding. A single nucleotide polymorphism in the NRT1.1 B gene between japonica and indica rice is responsible for the improved nitrogen use efficiency in indica rice. Herein, we precisely replaced the japonica NRT1.1 B allele with the indica allele, in just one generation, using CRISPR/Cas9 gene-editing technology.No additional selective pressure was needed to enrich the precise replacement events. This work demonstrates the feasibility of replacing any genes with elite alleles within one generation, greatly expanding our ability to improve agriculturally important traits. | Jingying Li Xin Zhang Yongwei Sun Jiahui Zhang Wenming Du Xiuping Guo Shaoya Li Yunde Zhao Lanqin Xia | 2018 | Journal of Integrative Plant Biology2018，60，7： | 11 |
| 6 | Strain hardening behavior of Mg-Y alloys after extrusion process显示文摘The strain hardening is an effective mode of enhancing mechanical properties in alloys.In this work,the strain hardening behaviors of Mg-xY(x=1,2,and 3 wt%)after extrusion process was investigated using uniaxial tensile tests.Results suggest that the Mg-xY alloys are composed ofα-Mg with a little amount of Mg24Y5 phase.The average grain size reduces from 19.8μm to 12.2μm as the Y content adds from 1 wt%to 2 wt%.Nevertheless,when Y content reaches 3 wt%,the grain size reaches to 12.9μm,which is close to that of Mg-2Y.The strain hardening rate decreases from 883 MPa to 798 MPa at(σ-σ0.2)=40 MPa,and Mg-2Y and Mg-3Y have the similar strain hardening response.Moreover,Mg-1Y shows an obvious ascending stage after the steep decreasing stage,which is mainly caused by the activation of twinning.The strain hardening behavior of Mg-xY is explained based on understanding the roles of the deformation mechanisms via deformation microstructure analysis and Visco-Plastic Self Consistent(VPSC)model.The variation of strain hardening characteristics with increasing Y content is related to the effects of grain size and texture. | Chaoyue Zhao Ziyan Li Jiahui Shi Xianhua Chen Teng Tu Zhu Luo Renju Cheng Andrej Atrens Fusheng Pan | 2019 | Journal of Magnesium and Alloys2019，7，4： | 6 |
| 7 | Characterization of particulate products for aging of ethylbenzene secondary organic aerosol in the presence of ammonium sulfate seed aerosol显示文摘Aging of secondary organic aerosol(SOA) particles formed from OH– initiated oxidation of ethylbenzene in the presence of high mass(100–300 μg/m^3) concentrations of(NH_4)_2SO_4seed aerosol was investigated in a home-made smog chamber in this study.The chemical composition of aged ethylbenzene SOA particles was measured using an aerosol laser time-of-flight mass spectrometer(ALTOFMS) coupled with a Fuzzy C-Means(FCM) clustering algorithm.Experimental results showed that nitrophenol,ethyl-nitrophenol,2,4-dinitrophenol,methyl glyoxylic acid,5-ethyl-6-oxo-2,4-hexadienoic acid,2-ethyl-2,4-hexadiendioic acid,2,3-dihydroxy-5-ethyl-6-oxo-4-hexenoic acid,1H-imidazole,hydrated N-glyoxal substituted1H-imidazole,hydrated glyoxal dimer substituted imidazole,1H-imidazole-2-carbaldehyde,N-glyoxal substituted hydrated 1H-imidazole-2-carbaldehyde and high-molecular-weight(HMW) components were the predominant products in the aged particles.Compared to the previous aromatic SOA aging studies,imidazole compounds,which can absorb solar radiation effectively,were newly detected in aged ethylbenzene SOA in the presence of high concentrations of(NH_4)_2SO_4seed aerosol.These findings provide new information for discussing aromatic SOA aging mechanisms. | Mingqiang Huang Jiahui Zhang Shunyou Cai Yingmin Liao Weixiong Zhao Changjin Hu Xuejun Gu Li Fang Weijun Zhang | 2016 | Journal of Environmental Sciences2016，28，9： | 6 |
| 8 | In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect显示文摘In the present work, the biodegradable behavior, cytocompatibility and osteogenesis activity of a Mg69Zn27Ca4 metal glass were investigated. Electrochemical test, immersion test, cytotoxicity test and histopathological evaluation were carried out. The results showed that there was a dense protective layer formed on the surface of Mg69Zn27Ca4 metal glass which could inhibit the degradation process in the Hank’s solution. In vitro cytotoxicity test showed that Mg69Zn27Ca4 metal glass had good biocompatibility. Histopathological evaluation showed that the degradation of Mg69Zn27Ca4 metal glass could promote the new bone formation with no obvious inflammatory reactions. After 2 months implantation, the diameter of the bone defect was reduced from the original φ6 mm to φ3.35 ± 0.40 mm with the degradation of Mg69Zn27Ca4 metal glass. Therefore, it can be concluded that Mg69Zn27Ca4 glass has great potential to be used as bone substitutes. | Junxiu Chen Jiahui Dong Huameng Fu Haifeng Zhang Lili Tan Dewei Zhao Ke Yang | 2019 | Journal of Materials Science & Technology2019，35，10： | 4 |
| 9 | 3D printing biomimeticmaterials and structures for biomedical applications显示文摘Over millions of years of evolution,nature has created organisms with overwhelming performances due to their unique materials and structures,providing us with valuable inspirations for the development of next-generation biomedical devices.As a promising new technology,3D printing enables the fabrication of multiscale,multi-material,and multi-functional threedimensional(3D)biomimetic materials and structures with high precision and great flexibility.The manufacturing challenges of biomedical devices with advanced biomimetic materials and structures for various applications were overcome with the flourishing development of 3D printing technologies.In this paper,the state-of-the-art additive manufacturing of biomimetic materials and structures in the field of biomedical engineering were overviewed.Various kinds of biomedical applications,including implants,lab-on-chip,medicine,microvascular network,and artificial organs and tissues,were respectively discussed.The technical challenges and limitations of biomimetic additive manufacturing in biomedical applications were further investigated,and the potential solutions and intriguing future technological developments of biomimetic 3D printing of biomedical devices were highlighted. | Yizhen Zhu Dylan Joralmon Weitong Shan Yiyu Chen Jiahui Rong Hanyu Zhao Siqi Xiao Xiangjia Li | 2021 | Bio-Design and Manufacturing2021，4，2： | 3 |
| 10 | Tranexamic acid for acute intracerebral haemorrhage growth based on imaging assessment (TRAIGE): a multicentre, randomised, placebo- controlled trial显示文摘Background Studies show tranexamic acid can reduce the risk of death and early neurological deterioration after intracranial haemorrhage.We aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in intracerebral haemorrhage patients susceptible to haemorrhage expansion.Methods We did a prospective,double-blind,randomised,placebo-controlled trial at 10 stroke centres in China.Acute supratentorial intracerebral haemorrhage patients were eligible if they had indication of haemorrhage expansion on admission imaging(eg,spot sign,black hole sign or blend sign),and were treatable within 8 hours of symptom onset.Patients were randomly assigned(1:1)to receive either tranexamic acid or a matching placebo.The primary outcome was intracerebral haematoma growth(>33% relative or>6 mL absolute)at 24 hours.Clinical outcomes were assessed at 90 days.Results Of the 171 included patients,124(72.5%)were male,and the mean age was 55.9±11.6 years.89 patients received tranexamic acid and 82 received placebo.The primary outcome did not differ significantly between the groups:36(40.4%)patients in the tranexamic acid group and 34(41.5%)patients in the placebo group had intracranial haemorrhage growth(OR 0.96,95% CI 0.52 to 1.77,p=0.89).The proportion of death was lower in the tranexamic acid treatment group than placebo group(8.1%vs 10.0%),but there were no significant differences in secondary outcomes including absolute intracranial haemorrhage growth,death and dependency.Conclusions Among patients susceptible to haemorrhage expansion treated within 8 hours of stroke onset,tranexamic acid did not significantly prevent intracerebral haemorrhage growth.Larger studies are needed to assess safety and efficacy of tranexamic acid in intracerebral haemorrhage patients. | Jingyi Liu Ximing Nie Hongqiu Gu Qi Zhou Haixin Sun Ying Tan Dacheng Liu Lina Zheng Jiahui Zhao Yan Wang Yibin Cao Haomeng Zhu Yunpeng Zhang Lijin Yi Yuehua Pu Miao Wen Zhonghua Yang Shengjun Sun Wenzhi Wang Xingquan Zhao Liping Liu Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 11 | Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis显示文摘The maturation and function of osteoblasts(OBs)rely heavily on the reversible phosphorylation of signaling proteins.To date,most of the work in OBs has focused on phosphorylation by tyrosyl kinases,but little has been revealed about dephosphorylation by protein tyrosine phosphatases(PTPases).SHP2(encoded by PTPN11)is a ubiquitously expressed PTPase.PTPN11 mutations are associated with both bone and cartilage manifestations in patients with Noonan syndrome(NS)and metachondromatosis(MC),although the underlying mechanisms remain elusive.Here,we report that SHP2 deletion in bone gamma-carboxyglutamate protein-expressing(Bglap+)bone cells leads to massive osteopenia in both trabecular and cortical bones due to the failure of bone cell maturation and enhanced osteoclast activity,and its deletion in Bglap+chondrocytes results in the onset of enchondroma and osteochondroma in aged mice with increased tubular bone length.Mechanistically,SHP2 was found to be required for osteoblastic differentiation by promoting RUNX2/OSTERIX signaling and for the suppression of osteoclastogenesis by inhibiting STAT3-mediated RANKL production by osteoblasts and osteocytes.These findings are likely to explain the compromised skeletal system in NS and MC patients and to inform the development of novel therapeutics to combat skeletal disorders. | Lijun Wang Huiliang Yang Jiahui Huang Shaopeng Pei Liyun Wang Jian Q.Feng Dian Jing Hu Zhao Henry M.Kronenberg Douglas C.Moore Wentian Yang | 2021 | Bone Research2021，9，1： | 3 |
| 12 | Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease显示文摘Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andfibrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD. | Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 3 |
| 13 | PbMC1a/1b regulates lignification during stone cell development in pear(Pyrus bretschneideri)fruit显示文摘Programmed cell death(PCD)and secondary cell wall(SCW)thickening in pear fruit are accompanied by the deposition of cellulose and lignin to form stone cells.Metacaspase is an important protease for development,tissue renewal and PCD.The understanding of the molecular mechanism whereby pear(Pyrus)metacaspase promotes PCD and cell wall lignification is still limited.In this study,the Metacaspases gene family(PbMCs)from P.bretschneideri was identified.PbMC1a/1b was associated with lignin deposition and stone cell formation by physiological data,semiquantitative real-time polymerase chain reaction(RT-PCR)and quantitative RT-PCR(qRT-PCR).Relative to wildtype(WT)Arabidopsis,the overexpression of PbMC1a/1b increased lignin deposition and delayed growth,thickened the cell walls of vessels,xylary fibers and interfascicular fibers,and increased the expression of lignin biosynthetic genes.Yeast two-hybrid(Y2H),bimolecular fluorescence complementation(BiFC)and GST pull-down assays indicated that the PbMC1a/1b protein physically interacted with PbRD21.Simultaneously,the transient expression of PbMC1a/1b and PbRD21 led to significant changes in the expression of genes and lignin contents in pear fruits and flesh calli.These results indicate that PbMC1a/1b plays an important role in cell wall lignification,possibly by interacting with PbRD21 to increase the mRNA levels of some lignin synthesis-associated genes and promote the formation of stone cells in pear fruit. | Xin Gong Zhihua Xie Kaijie Qi Liangyi Zhao Yazhou Yuan Jiahui Xu Weikang Rui Katsuhiro Shiratake Jianping Bao Shahrokh Khanizadeh Shaoling Zhang Shutian Tao | 2020 | Horticulture Research2020，7，1： | 3 |
| 14 | ClusterSLAM:A SLAM backend for simultaneous rigid body clustering and motion estimation显示文摘We present a practical backend for stereo visual SLAM which can simultaneously discover individual rigid bodies and compute their motions in dynamic environments.While recent factor graph based state optimization algorithms have shown their ability to robustly solve SLAM problems by treating dynamic objects as outliers,their dynamic motions are rarely considered.In this paper,we exploit the consensus of 3 D motions for landmarks extracted from the same rigid body for clustering,and to identify static and dynamic objects in a unified manner.Specifically,our algorithm builds a noise-aware motion affinity matrix from landmarks,and uses agglomerative clustering to distinguish rigid bodies.Using decoupled factor graph optimization to revise their shapes and trajectories,we obtain an iterative scheme to update both cluster assignments and motion estimation reciprocally.Evaluations on both synthetic scenes and KITTI demonstrate the capability of our approach,and further experiments considering online efficiency also show the effectiveness of our method for simultaneously tracking ego-motion and multiple objects. | Jiahui Huang Sheng Yang Zishuo Zhao Yu-Kun Lai Shi-Min Hu | 2021 | Computational Visual Media2021，7，1： | 3 |
| 15 | Porous silicon carbide coated with tantalum as potential material for bone implants显示文摘Porous silicon carbide(SiC)has a specific biomorphous microstructure similar to the trabecular microstructure of human bone.Compared with that of bioactive ceramics,such as calcium phosphate,SiC does not induce spontaneous interface bonding to living bone.In this study,bioactive tantalum(Ta)metal deposited on porous SiC scaffolds by chemical vapour deposition was investigated to accelerate osseointegration and improve the bonding to bones.Scanning electron microscopy indicated that the Ta coating evenly covered the entire scaffold structure.Energy-dispersive spectroscopy and X-ray diffraction analysis showed that the coating consisted of Ta phases.The bonding strength between the Ta coating and the SiC substrate is 88.4MPa.The yield strength of porous SiC with a Ta coating(pTa)was 45.862.9MPa,the compressive strength was 61.463.2MPa and the elasticmodulus was4.8GPa.When MG-63 human osteoblasts were co-cultured with pTa,osteoblasts showed good adhesion and spreading on the surface of the pTa and its porous structure,which showed that it has excellent bioactivity and cyto-compatibility.To further study the osseointegration properties of pTa.PTa and porous titanium(pTi)were implanted into the femoral neck of goats for 12weeks,respectively.The Van-Gieson staining of histological sections results that the pTa group had better osseointegration than the pTi group.These results indicate that coating bioactive Ta metal on porous SiC scaffolds could be a potential material for bone substitutes. | Zhijie Ma Jingyu Li Fang Cao Jiahui Yang Rong Liu Dewei Zhao | 2020 | Regenerative Biomaterials2020，7，5： | 3 |
| 16 | Synergistic effect enhances the peroxidase-like activity in platinum nanoparticle-supported metal—organic framework hybrid nanozymes for ultrasensitive detection of glucose显示文摘The metal—organic frameworks(MOFs)are expected as ideal biomimetic enzymes for colorimetric glucose detection because of their large surface areas,well defined pore structures,tunable chemical composition,and multi-functional sites.However,the intrinsically chemical instability and low mimetic enzyme activity of MOFs hinder the application of them in imitating the enzyme reactions.In this work,we demonstrated a metal-MOF synergistic catalysis strategy,by loading Pt nanoparticles(Pt NPs)on MIL-88B-NH2(Fe-MOF)to increase peroxidase-like activity for the detection of glucose.The induced electrons transfer from Pt atom to Fe atom accelerated the redox cycling of Fe^(3+)/Fe^(2+),improved the overall efficiency of the peroxidase-like reaction,and enabled the efficient and robust colorimetric glucose detection,which was proved by both experiments and density functional theory(DFT)calculation.Additionally,the sensitivity and chemical stability of this synergistic effect strategy to detect the glucose are not affected by the complex external factors,which represented a great potential in fast,easy,sensitive,and specific recognition of clinical diabetes. | Jing Li Jie Zhao Shengqiang Li Yang Chen Weiqiang Lv Jiahui Zhang Libing Zhang Zhen Zhang Xiaoquan Lu | 2021 | Nano Research2021，14，12： | 2 |
| 17 | Prediction of stable BC_(3)N_(2)monolayer from first-principles calculations:Stoichiometry,crystal structure,electronic and adsorption properties显示文摘In this paper,a novel BC_(3)N_(2)monolayer has been found with a graphene-like structure using the developed particle swarm optimization algorithm in combination with ab initio calculations.The predicted structure meets the thermodynamical,dynamical,and mechanical stability requirements.Interestingly,the BC_(3)N_(2)plane shows a metallic character.Importantly,BC_(3)N_(2)has an in-plane stiffness comparable to that of graphene.We have also investigated the adsorption characteristics of CO_(2)on pristine monolayer and Mo functionalized monolayer using density functional theory.Subsequently,electronic structures of the interacting systems(CO_(2)molecule and substrates)have been preliminarily explored.The results show that Mo/BC_(3)N_(2)has a stronger adsorption capacity towards CO_(2)comparing with the pristine one,which can provide a reference for the further study of the CO_(2)reduction mechanism on the transition metal-functionalized surface as well as the new catalyst’s design. | Jiahui Yu Chaozheng He Chunying Pu Ling Fu Dawei Zhou Kun Xie Jinrong Huo Chenxu Zhao Lingmin Yu | 2021 | Chinese Chemical Letters2021，32，10： | 2 |
| 18 | State of the art:Lateral flow assay(LFA) biosensor for on-site rapid detection显示文摘Recently, lateral flow assay(LFA) has attracted researchers' attention because of its considerable advantages of superior portability, rapid detection, cost-effectiveness and ease of use. This review provides a brief overview of latest researches of LFA, including the practical use of LFA in both qualitative and quantitative analysis in different areas. Though bio-recognition molecules in the LFA used to be antibodies, a new kind of recognition element called aptamer, showing significant advantages, is developed rapidly in recent years. The highly specific recognition of aptamers/antibodies and targets are combined with the excellent properties of a dry-reagent strip biosensor that enables efficiently detection in point-of-care applications. Herein, we compared the aptamers with antibodies, summarized the principle of LFAs, and three main elements for the LFAs(recognition molecule, signal transduction element, the targets). Additionally, we summarized different optimal experimental conditions in the recent LFA-related studies to give detailed overview of the LFA development. We hope the review can give a general guide for the development of LFAs. | Shuai Zhao Sai Wang Shan Zhang Jiahui Liu Yiyang Dong | 2018 | Chinese Chemical Letters2018，29，11： | 2 |
| 19 | Erratum to:Herbal decoctosome is a novel form of medicine显示文摘Following the published article,we noticed an error duplication in Figure 5G“control”and“PGY-6”that was introduced during the revised process,with an attempt to replace it with higher-resolution images.Here we provide the original data in the first submitted manuscript(Figure 5G). | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao Dandan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 20 | NIR-to-NIR UCL/T_1-weighted MR/CT multimodal imaging by NaYbF_4:Tm@NaGdF_4:Yb-PVP upconversion nanoparticles显示文摘Multimodal imaging nanoprobes are urgently sought because they can integrate different imaging function into individual nanoplatform and provide more comprehensive and accurate information for the diagnosis of early-stage tumor.Lanthanide-based upconversion nanoparticles(UCNPs) are regarded as promising nanoplatforms to fabricate these probes.Herein,we firstly developed the active core-active shell structured NaYbF_4:Tm@NaGdF_4:Yb-PVP UCNPs with the average diameter of 13.23±0.96 nm as multimodal imaging probes.These water-dispersible nanoprobes presented excellent near-infrared to near-infrared(NIR-to-NIR) upconversion luminescence(UCL) performance,which is favorable for optical bioimaging due to deeper tissue penetration and autofluorescence reduction.After coated with the NaGdF_4:Yb active shell,the UCL emission intensity at 800 nm increased by 7.2 times.These nanoprobes exhibited a desirable longitudinal relaxivity(r_1=3.58 L/(mmol s)) and strong X-ray attenuation property(58.84 HU L/g).The cytotoxicity assessment,histology analysis and biodistribution study revealed that NaYbF_4:Tm@NaGdF_4:Yb-PVP UCNPs had relatively low cytotoxicity and negligible organ toxicity.These UCNPs were applied for NIR-to-NIR UCL imaging in vivo.More importantly,the detection of small tumor was successfully achieved under T_1-weighted MRI and CT imaging modalities after intravenous injection of these UCNPs.These results revealed that NaYbF_4:Tm@NaGdF_4:Yb-PVP UCNPs could serve as promising NIR-to-NIR UCL/MRI/CT trimodal imaging probes. | Tao Wang Min Yang Jiahui Huang Yanzhi Zhao Honglei Wang Shuang Leng Jinxing Chen Guoying Sun Jianhua Liu | 2017 | Science Bulletin2017，62，13： | 2 |
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