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| 1 | Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells显示文摘痛风的关节炎是被 monosodium urate (MSU ) 的累积在关节引起晶体的煽动性的疾病。MSU 能够激活核苷酸绑定 oligomerization 包含 3 的像域的受体 pyrin 领域(NLRP3 ) inflammasome,导致 interleukin-1β(IL-1β) 分泌物。反应的氧种类(ROS ) 是 NLRP3/IL-1β 的主要调停人;相互作用。尽管原子因素 E2 相关的因素(Nrf2 ) 2 作为一个抄写因素被认出涉及对氧化应力的反应, Nrf2 上并且在调停 Nrf2 的抗氧化剂酶上的 MSU 的效果仍然保持不清楚。用 phorbol 12 十四酸盐 13 醋酸盐(PMA ) 的 THP-1 单核白血球的处理被显示开始煽动性的回答。这里,我们显示出那 THP-1 房间,有 MSU 晶体的后面的处理,显著地增加的 IL-1β版本, NLRP3 inflammasome 激活和 ROS 生产。MSU 也支持了 Nrf2 的原子 translocation 并且激活 lysosomal destabilization。而且,在基因和蛋白质表情的 heme oxygenase-1 (HO-1 ) 的层次是由 MSU 的 upregulated。导致 MSU 的 IL-1β分泌物和 NLRP3 inflammasome 激活被禁止由 Nrf2 并且经由 HO-1 禁止者锌(II ) 击倒 protoporphyrin IX (ZnPP ) 。另外, HO-1 抑制增加了 superoxide 阴离子生产和谷胱甘肽的消费的水平。这些调查结果建议 Nrf2 和 HO-1 调停氧化还原作用动态平衡并且在质问 MSU 的 THP-1 房间与支持 inflammatory 因素交往,从而提供导致 MSU 的痛风的发炎怎么被涉及 Nrf2/Ho-1 的特定的机制调停的新卓见抗氧化剂发信号小径。 | Jhih-Jia Jhang Yu-Ting Cheng Cheng-Ying Ho Gow-Chin Yen | 2015 | Cellular & Molecular Immunology2015，12，4： | 15 |
| 2 | 围手术期化疗与术后化疗对行手术切除晚期胃癌病人预后影响对比研究显示文摘目的研究围手术期化疗与术后化疗对行手术切除晚期胃癌病人的预后影响。方法回顾性分析2004年1月至2016年12月南方医科大学南方医院普通外科行胃切除手术治疗的Ⅳ期胃癌病人资料。其中,行手术切除联合术后辅助化疗228例(术后化疗组,A组),行术前化疗+手术切除+术后化疗49例(围手术期化疗组,B组)。采用倾向得分匹配法(PSM)均衡组间混杂因素的影响,选取8个协变量进行1∶1匹配(性别、年龄、肿瘤生物学分类、化疗完成度、术后病理的肿瘤浸润深度分期、淋巴结转移分期、淋巴结清扫范围、胃切除范围),最终49例A组病人和49例B组病人成功进行匹配。采用Kaplan-Merier法进行生存分析,应用Cox比例风险回归模型对行手术切除的晚期胃癌病人进行独立生存危险因素的分析。结果匹配前,两组病人的肿瘤生物学分类(P<0.001)、化疗周期(P<0.001)、肿瘤浸润深度分期(P<0.001)、淋巴结转移分期(P=0.049)、淋巴结清扫范围(P=0.001)、胃切除范围(P=0.001)等差异有统计学意义,而匹配之后,仅有化疗完成度(P<0.001)在两组间差异有统计学意义,B组的化疗完成度优于A组。匹配之后,A组中位生存时间(MST)为16个月(95%CI 10.36~21.64),与B组MST 29个月(95%CI 17.24~40.76)之间差异无统计学意义(P=0.191)。生存单因素分析显示,生物学分类、化疗周期、淋巴结转移情况和淋巴结清扫情况等四个因素可影响行手术切除晚期胃癌病人的生存预后,进一步多因素分析提示,化疗周期≤2次,淋巴结转移、淋巴结清扫范围不足D2等3个因素为独立预后不良因素。化疗与手术的先后次序(围手术期化疗相比术后化疗)并不影响病人生存预后(HR 0.986,95%CI 0.539~1.806,P=0.964)。结论相比术后化疗,围手术期化疗并不是改善行手术切除晚期胃癌病人生存预后的独立因素,但能够使病人有更好的化疗耐受性和依从性,从而使其生存显著优于术后开始化疗的病人。这可为后续晚期胃癌治疗的前瞻性研究设计提供参考和指导。 | 陈新华 陈粤泓 罗俊 李涛 林填 李团结 刘浩 胡彦锋 赵明利 陈豪 JHANG LOPSANGGURUNG 李国新 余江 | 2019 | 中国实用外科杂志2019，0，8： | 9 |
| 3 | Prognostic value and nomograms of proximal margin distance in gastric cancer with radical distal gastrectomy显示文摘Objective:The proximal margin(PM)distance for distal gastrectomy(DG)of gastric cancer(GC)remains controversial.This study investigated the prognostic value of PM distance for survival outcomes,and aimed to combine clinicopathologic variables associated with survival outcomes after DG with different PM distance for GC into a prediction nomogram.Methods:Patients who underwent radical DG from June 2004 to June 2014 at Department of General Surgery,Nanfang Hospital,Southern Medical University were included.The first endpoints of the prognostic value of PM distance(assessed in 0.5 cm increments)for disease-free survival(DFS)and overall survival(OS)were assessed.Multivariate analysis by Cox proportional hazards regression was performed using the training set,and the nomogram was constructed,patients were chronologically assigned to the training set for dates from June 1,2004 to January 30,2012(n=493)and to the validation set from February 1,2012 to June 30,2014(n=211).Results:Among 704 patients with p TNM stage I,p TNM stage II,T1-2,T3-4,N0,differentiated type,tumor size≤5.0 cm,a PM of(2.1-5.0)cm vs.PM≤2.0 cm showed a statistically significant difference in DFS and OS,while a PM>5.0 cm was not associated with any further improvement in DFS and OS vs.a PM of 2.1-5.0 cm.In patients with p TNM stage III,N1,N2-3,undifferentiated type,tumor size>5.0 cm,the PM distance was not significantly correlated with DFS and OS between patients with a PM of(2.1-5.0)cm and a PM≤2 cm,or between patients with a PM>5.0 cm and a PM of(2.1-5.0)cm,so there were no significant differences across the three PM groups.In the training set,the C-indexes of DFS and OS,were 0.721 and 0.735,respectively,and in the validation set,the C-indexes of DFS and OS,were 0.752 and 0.751,respectively.Conclusions:It is necessary to obtain not less than 2.0 cm of PM distance in early-stage disease,while PM distance was not associated with long-term survival in later and more aggressive stages of disease because more advanced GC is a systemic disease.Different types of patients should be considered for removal of an individualized PM distance intra-operatively.We developed a universally applicable prediction model for accurately determining the 1-year,3-year and 5-year DFS and OS of GC patients according to their preoperative clinicopathologic characteristics and PM distance. | Jun Luo Yuming Jiang Xinhua Chen Yuehong Chen Jhang Lopsang Gurung Tingyu Mou Liying Zhao Guoqing Lyu Tuanjie Li Guoxin Li Jiang Yu | 2020 | Chinese Journal of Cancer Research2020，32，2： | 8 |
| 4 | The role of Nrf2 in NLRP3 inflammasome activation显示文摘The nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3(NLRP3)inflammasome is one of the pattern recognition receptors for host defense against pathogen-associated molecular patterns and danger-associated molecular patterns.The NLRP3 inflammasome is a best characterized as a multiprotein complex composed of NLRP3,apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC)adaptor,and pro-caspase-1.The NLRP3 inflammasome is activated by select activators or pathogen stimuli,and a conformational change of inflammasome-forming NOD-like receptor(NLR)enables NLR binding to ASC via pyrin domains. | Jhih-Jia Jhang Gow-Chin Yen | 2017 | Cellular & Molecular Immunology2017，14，12： | 6 |
| 5 | Acoustic Nonlinearity of a Laser-Generated Surface Wave in a Plastically Deformed Aluminum Alloy显示文摘The acoustic nonlinearity of surface waves is studied to evaluate plastic deformation in aluminum alloys.A narrow-band surface wave is successfully generated by a pulsed Nd-YAG laser system consisting of a beam expander and a slit mask.Various degrees of tensile deformation are induced by interrupting the tensile tests so as to obtain aluminum specimens with different degrees of plastic damage.The normalized acoustic nonlinearity increases as a function of tensile strain.The experimental results show that the acoustic nonlinearity of a laser-generated surface wave has a good correlation with the level of tensile deformation and has a potential to evaluate microdamage induced by dislocation microplasticity. | KIM Chung-Seok JHANG Kyung-Young | 2012 | Chinese Physics Letters2012，29，12： | 2 |
| 6 | Fatigue-Induced Micro-damage Characterization of Austenitic Stainless Steel 316 Using Innovative Nonlinear Acoustics显示文摘We present innovative nonlinear acoustics for characterizing fatigue-induced micro-damage of austenitic stainless steel 316 subjected to high-cycle fatigue.Various fatigue-driven deformations are accumulated at several positions near the middle of hourglass-shaped specimens.A bell-shaped curve of acoustic nonlinearity as a function of position is observed,and the variation in acoustic nonlinearity is attributed to the evolution of a lattice defect (dislocation) and stress-induced martensite based on transmission electron microscopy (TEM) observations.An oblique incidence technique using a longitudinal waveform is a potentially viable method for characterizing the high-cycle fatigue deformation of austenitic stainless steel 316 alloys. | Chung-Seok KIM Kyung-Young JHANG | 2012 | Chinese Physics Letters2012，29，6： | 2 |
| 7 | Applications of Nonlinear Ultrasonics to the NDE of Material Degradation 显示文摘 | JHANG K Y | 2000 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2000，47，3： | 1 |
| 8 | Application of particle swarm algorithm to optimization of unequally spaced antenna arrays显示文摘 | LEE K C JHANG J Y | 2006 | Journal of Electromagnetic Waves and Applications2006，20，14： | 1 |
| 9 | Relationship between second-and third-order acoustic nonlinear parameters in relative measurement显示文摘 | Ren Gang Kim Jongboem Jhang Kyung-Young | 2015 | Ultrasonics2015，，56： | 1 |
| 10 | Differentiated thyroid carcinoma that express sodium-iodide symporter have a lower risk of recurrence for children and adolescents显示文摘 | Patel A Jhang S Dogra S | 2002 | Pediatr Res2002，52，5： | 1 |
| 11 | Applications of nonlinear ultrasonics to the NDE of material degradation显示文摘 | JHANG K Y | 2000 | IEEE-UFFC2000，47，3： | 1 |
| 12 | Perioperative evaluation of airways in patients with arch obstruction and intracardiac defects显示文摘 | JHANG WK PARK JJ | 2008 | Ann Thorac Surg2008，85，： | 1 |
| 13 | Impact of delayed sternal closure on postoperative infection or wound dehiscence in patients with congenital heart disease显示文摘 | Shin HJ Jhang WK Park JJ | | 0，，02： | 1 |
| 14 | Estimation of clamping force in high tension bolts through ultrasonic velocity measurement显示文摘 | Jhang K Y Quan H H Ha J | 2006 | Ultrasonics2006，44，1： | 1 |
| 15 | Properties of single - wall carbon nanotubes显示文摘 | Yu H Jhang S Park Y | 2001 | Synthetic metals2001，121，： | 1 |
| 16 | Mitomycin C-induced reduction of keratocytes and fibroblasts after photorefractive keratectomy 显示文摘 | Kim Tae-im Jhang HP Sun YL | 2004 | Invest Ophthalmol Vis Sei2004，45，： | 1 |
| 17 | Evaluation of linearity in clinical laboratory显示文摘 | Jhang JS Chang CC Fink DJ | 2004 | Arch Pathol Lab Med2004，128，1： | 1 |
| 18 | Cytotoxic diarylheptanoids from the roots of Juglans mandshurica 显示文摘 | Lee KS Li G Kim SH Lee CS Woo MH Lee SH Jhang YD Son JK | 2002 | J Nat Prod2002，65，11： | 1 |
| 19 | Steam reforming of methanol over CuO/ZnO/CeO2/ZrOJA1203 catalysts显示文摘 | HUANG G LIAW B J JHANG C J CHEN Y Z | 2009 | Appl Catal A: Gen2009，358，1： | 1 |
| 20 | Perioperative evaluation o显示文摘 | Jhang WK Park JJ Seo DM | 2008 | Ann Thorac Surg2008，85，17： | 1 |
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