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| 1 | A Systematic Review of Anticancer Effects of Radix Astragali显示文摘Objective:To review the anticancer effects of Radix astragali(RA),one of the most commonly used herbs to manage cancer in East Asia,and its constituents and to provide evidence of clinical usage through previously performed clinical studies.Methods:Preclinical and clinical studies related to the anticancer effects of RA were searched from inception to November 2013 in electronic databases.Two reviewers independently investigated 92 eligible studies,extracted all the data of studies and appraised methodological quality of clinical trials.The studies were categorized into in vitro and in vivo experimental studies and clinical studies,and analyzed by saponins,polysaccharides,and flavonoids of RA constituents,RA fraction,and whole extract.Results:In preclinical studies,RA was reported to have tumor growth inhibitory effects,immunomodulatory effects,and attenuating adverse effects by cytotoxic agents as well as chemopreventive effects.Saponins seemed to be the main constituents,which directly contributed to suppression of tumor growth through the activation of both intrinsic and extrinsic apoptotic pathway,modulation of intracellular signaling pathway,and inhibition of invasion and angiogenesis.Flavonoids suppressed tumor growth through the similar mechanisms with saponins.Polysaccharides showed immunomodulatory effects,contributing tumor shrinkages in animal models,despite the low cytotoxicity to cancer cells.Most of the clinical studies were performed with low evidence level of study designs because of various limitations.RA whole extracts and polysaccharides of RA were reported to improve the quality of life and ameliorate myelosuppression and other adverse events induced by cytotoxic therapies.Conclusion:The polysaccharides,saponins,and flavonoids of RA,and the whole extract of RA have been widely reported with their anticancer effects in preclinical studies and showed a potential application as a adjunctive cancer therapeutics with the activities of immunomodulation,anti-proliferation and attenuation of adverse effects induced by cytotoxic therapy. | Yeehong Jung Uimin Jerng Sookyung Lee | 2016 | Chinese Journal of Integrative Medicine2016，22，3： | 9 |
| 2 | The effectiveness and safety of acupuncture for poor semen quality in infertile males: a systematic review and meta-analysis显示文摘这评论的目的在不肥沃的人是为差的精液评估针灸的有效性和安全优秀的。我们寻找了在 14 个数据库登记直到 2013 年 5 月的相关审判。我们选择了比较了针灸的使随机化的控制审判(RCT ) ,与或没有另外的治疗,对安慰剂,假冒,没有治疗,或一样的另外的治疗。二个评论家独立地执行了学习选择,数据抽取,偏爱的风险和报导优秀估价。偏爱和报导质量的风险被偏爱工具,报导试用的巩固的标准和标准的 Cochrane 风险为在针灸的临床的试用报导干预估价。结果是精子活动性,精子集中,怀孕率,和不利事件。怀孕被定义为积极怀孕测试。四 RCT 满足了资格标准。针灸与快速的前进增加了精子的百分比(吝啬的差别 - 6.35, 95% 信心间隔(CI ) :4.38-8.32, P<0.00001 ) 并且精子集中(吝啬的差别 - 6.42, 95% CI:4.91-7.92, P<0.00001 ) ,但是这二结果在研究之中是实质地异构的(我 2=72% 和 58% ,分别地) 。处于怀孕率的差别都没在针灸之间被发现并且控制组(机会比率 1.60, 95% CI:0.70-3.69, P= 0.27,我 2=0%) 。没有参加者经历了不利事件。因为研究,过程的机能不全或为精液分析,异质的高水平,偏爱的高风险,和报导的差的质量的不够的信息的小数字,证明针灸力量改进差的精液质量的当前的证据是不够的。进一步大的、设计得好的 RCT 被要求。 | Ui Min Jerng Jun-Young Jo Seunghoon Lee Jin-Moo Lee Ohmin Kwon | 2014 | Asian Journal of Andrology2014，16，6： | 3 |
| 3 | Low serum level of high- density lipoprotein cholesterol is a poor prognostic factor for severe sepsis显示文摘 | Chien JY Jerng JS Yu CJ | 2005 | Crit Care Med2005，33，8： | 1 |
| 4 | Diagnostic value of procalcitonin in pleural effusions 显示文摘 | WANG CY HSIAO YC JERNG JS | 2011 | Eur J Clin Microbiol Infect Dis2011，30，3： | 1 |
| 5 | The impact of device type and sizing on phase noise mechanisms 显示文摘 | JERNG A SODINI C G | 2005 | IEEE J Sol Sta Circ2005，40，2： | 1 |
| 6 | Diagnostic value of procalcitonin in pleural effusions显示文摘 | Wang CY Hsiao YC Jerng JS | 2011 | Eur J Clin Microbiol Infect Dis2011，30，3： | 1 |
| 7 | Inactivation gating of Kv4 potassium channels:molecular interactions involving the inner vestibule of the pore显示文摘 | Shahidullah M Covarrubias M | 1999 | J Gen Physiol1999，113，： | 1 |
| 8 | Candida glabrata fungaemia in intensive care units显示文摘 | Ruan SY Lee LN Jerng JS | 2008 | Clin Microbiol Infect2008，14，2： | 1 |
| 9 | Low Serum Level of High-density Lipoprotein Cholesterol is A Poor Prognostic Factor for Severe Sepsis显示文摘 | Chien J Y Jerng J S Yu C J | 2005 | Crit Care Med2005，33，8： | 1 |
| 10 | The Impact of device type and sizing on phase noise mechanisms显示文摘 | Jerng A Sodini C G | 2005 | IEEE J Sol Sta Circ2005，40，2： | 1 |
| 11 | The impact of device and sizing on phase noise mechanisms显示文摘 | Jerng A Sodini C G | 2005 | IEEE Journal of Sol- id-State Circuits2005，40，2： | 1 |
| 12 | Diagnostic value of proealci- tonin in pleural effusions 显示文摘 | Wang CY Hsiao YC Jerng JS | 2011 | Eur J Clin Microbiol Infect Dis2011，30，3： | 1 |
| 13 | The impact of deviee type and sizing on phase noise mechanisms 显示文摘 | JERNG A SODINI C G | 2005 | IEEE J Sol Sta Circ2005，40，2： | 1 |
| 14 | Polymorphism of the angiotensin-converting enzyme gene affects the outcome of acute respiratory distress syndrome显示文摘 | Jerng JS Yu CJ Wang HC | | 0，，： | 1 |
| 15 | Role of the renin-Angiotensin systerm in ventilator-induced lung injury:an in vivo study in a rat model显示文摘 | Jerng JS Hsu YC Wu HD | | 0，，06： | 1 |
| 16 | Ultrasonographic evaluation of liver/spleen movements and extubation outcome 显示文摘 | Jiang JR Tsai TH Jerng JS | 2004 | Chest2004，126，1： | 1 |
| 17 | Pneumothorax in the ICU:patient outcomes and prognostic factors 显示文摘 | Chen KY Jerng JS Liau WY | | Chest0，122，2： | 1 |
| 18 | Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis显示文摘 | Chien JY Jerng JS Yu CJ | | 0，，08： | 1 |
| 19 | Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis显示文摘 | Chien J Y Jerng J S Yu C J | 2005 | Crit Care Med2005，33，： | 1 |
| 20 | Ultrasonographic evaluation of liver/spleen movements and extubation outcome显示文摘 | Jiang JR Tsai TH Jerng JS | 2004 | Chest2004，126，1： | 1 |
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