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| 1 | Genetically modified mouse models for the study of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 diabetes.NAFLD represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) cirrhosis.The animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of NASH.The study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely understood.The different mouse models can be classified in two large groups.The first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological manipulation.Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of NAFLD.Ideal animal models for NASH should closely resemble the pathological characteristics observed in humans.To date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human disease.Therefore,it is important that the researchers choose the appropriate animal model.This review discusses various genetically modified animal models developed and used in research on NAFLD. | Perumal Nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma | 2012 | World Journal of Gastroenterology2012，18，11： | 7 |
| 2 | Phytoremediation of organic and nutrient contaminants显示文摘 | JERALD L SCHNOOR L A LICHT S C | 1995 | Environ Sc & Technol1995，29，7： | 1 |
| 3 | Tradeoffs in the organization of production: Muhiunit firms, geographic dispersion and organizational learning 显示文摘 | Audia P G Jerald H O S | 2001 | Mulfiunit Organization and Muhimarket Strategy2001，18，： | 1 |
| 4 | Risk of Surgery Mter Use of Potassium Chloride for Treatment of Tubal Heteretopic Pregnancy显示文摘 | Goldstein Jerald S Ratts Valerie S | 2006 | Am T Obstest Gynecool2006，107，9： | 1 |
| 5 | Electrochemical degradation of 1, 2-dichloroethane (DCA) in a synthetic groundwater medium using stainless-steel electrodes显示文摘 | RAIESH B JERALD A L RAIESH S | 2005 | Water Res2005，39，19： | 1 |
| 6 | Capillary Column Gas Chromatography of Sulfur Heterocycles in Heavy Oils and Tars Using a Biphenylpolysiloane Stationary Phase显示文摘 | Masaharu Nishioka Jerald S Bradshaw Milton L Lee | 1985 | Anal Chem1985，57，： | 1 |
| 7 | Application of a- daptive genetic algorithm and particle swarm optimisation in schedulingof jobs and AS/RS in FMS显示文摘 | P Asokan J Jerald S Arunachalam T Page | 2008 | International Journal of Manufacturing Research2008，3，4： | 1 |
| 8 | A mild esterification process in phosphonium salt ionic liquid 显示文摘 | MCNULTY J CHEEKOORI S JERALD J | 2005 | Tetrahedron Letters2005，46，21： | 1 |
| 9 | Syntheses of Some Medium Sized Cyclic Triamines and Their Cobalt(Ⅲ) Complexes显示文摘 | Jerald S Braashaw Stott P E | 1972 | Bull Chem Soc1972，45，： | 1 |
| 10 | Process Research,Development, and Pilot-plant Preparation of Clofencet, a Novel Wheat Hybridizing Agent: Lewis Acid-catalyzed Reaction of Ethyl Diazoacetate with 4-Chlorophenyl Hydrazonoacetaidehyde显示文摘 | JERRY D C JERALD D H AJIT S S | 2004 | Proc Res Dev2004，8，： | 1 |
| 11 | Phytoremediation of polychlorinated biphenyls:New trends and promises 显示文摘 | Benoit V A Paola A C Jerald L S | 2011 | Environmental Science& Technology2011，44，： | 1 |
| 12 | Benzo pyrene cometabolism in the presence of plant root extracts and exudates: Implications for phytoremediation 显示文摘 | Jeremy A R Pdero J A Jerald L S | 2005 | Environ Pollut2005，136，3： | 1 |
| 13 | Using the Box-Benkhen Tech- nique to Statistically Model Phenol Photocatalytic Degra- dation by Titanium Dioxide Nano Particles 显示文摘 | Ray S Jerald L Nihar B | 2009 | Chemical Engineering Journal2009，169，13： | 1 |
| 14 | Syn- thesis of (allyloxy)methyl-substituted diaza-18-crown- 6 compounds for attachment to silica gel 显示文摘 | Jerald S B Krzysztof E K Ronald L B | 1988 | J Org Chem1988，53，： | 1 |
| 15 | Targeting the platelet-derived growth factor receptor in anti-vascular therapy for human ovarian carcinoma显示文摘 | Apte S M Fan D Jerald J | 2004 | Clinical Cancer Res2004，10，3： | 1 |
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