6篇
您的检索式：作者名="Janusz Rak"
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| 1 | Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src显示文摘Senescent endothelial cells (ECs) could impair the integrity of the blood vessel endothelium, leading to vascular aging and a series of diseases, such as atherosclerosis, diabetes. Preventing or mitigating EC senescence might serve as a promising therapeutic paradigm for these diseases. Recent studies showed that small extracellular vesicles (sEV) have the potential to transfer bioactive molecules into recipient cells and induce phenotypic changes. Since mesenchymal stem cells (MSCs) have long been postulated as an important source cell in regenerative medicine, herein we investigated the role and mechanism of MSC-derived sEV (MSC-sEV) on EC senescence. In vitro results showed that MSC-sEV reduced senescent biomarkers, decreased senescence-associated secretory phenotype (SASP), rescued angiogenesis, migration and other dysfunctions in senescent EC induced by oxidative stress. In the In vivo natural aging and type-2 diabetes mouse wound-healing models (both of which have senescent ECs), MSC-sEV promoted wound closure and new blood vessel formation. Mechanically, miRNA microarray showed that miR-146a was highly expressed in MSC-sEV and also upregulated in EC after MSC-sEV treatment. miR-146a inhibitors abolished the stimulatory effects of MSC-sEV on senescence. Moreover, we found miR-146a could suppress Src phosphorylation and downstream targets VE-cadherin and Caveolin-1. Collectively, our data indicate that MSC-sEV mitigated endothelial cell senescence and stimulate angiogenesis through miR-146a/Src. | Xian Xiao Meiqian Xu Hongliang Yu Liping Wang Xiaoxia Li Janusz Rak Shihua Wang Robert Chunhua Zhao | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 5 |
| 2 | Microparticles in Cancer显示文摘 | Janusz Rak | 2010 | Semin Thromb Hemost2010，，08： | 1 |
| 3 | Oncogenes and tumor angiogenesis:The question of vascular 'supply' and vascular'demand'显示文摘 | Janusz Rak Joanne L Yu | 2004 | Seminars in Cancer Biology2004，14，2： | 1 |
| 4 | Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer显示文摘 | Jian-Guo Wang Julia E. Geddings Maria M. Aleman Jessica C. Cardenas Pichika Chantrathammachart Julie C. Williams Daniel Kirchhofer Vladimir Y. Bogdanov Ronald R. Bach Janusz Rak Frank C. Church Alisa S. Wolberg Rafal Pawlinski Nigel S. Key Jen Jen Yeh Nig | 2012 | Blood2012，，23： | 1 |
| 5 | Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state显示文摘 | Delphine Garnier Nathalie Magnus Brian Meehan Thomas Kislinger Janusz Rak | 2013 | Experimental Cell Research2013，，17： | 1 |
| 6 | Correction to:Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src显示文摘In the process of collating the raw data,the authors noticed several inadvertent mistakes occurred in Fig.1b,Fig.2d,f,l,and Supplementary Fig.1b that need to be corrected after online publication of the article1.The correct data are provided as follows.The key findings of the article are not affected by these corrections.The original article has been corrected. | Xian Xiao Meiqian Xu Hongliang Yu Liping Wang Xiaoxia Li Janusz Rak Shihua Wang Robert Chunhua Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
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