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| 1 | The role of mechanotransduction versus hypoxia during simulated orthodontic compressive strain——an in vitro study of human periodontal ligament fibroblasts显示文摘During orthodontic tooth movement(OTM)mechanical forces trigger pseudo-inflammatory,osteoclastogenic and remodelling processes in the periodontal ligament(PDL)that are mediated by PDL fibroblasts via the expression of various signalling molecules.Thus far,it is unknown whether these processes are mainly induced by mechanical cellular deformation(mechanotransduction)or by concomitant hypoxic conditions via the compression of periodontal blood vessels.Human primary PDL fibroblasts were randomly seeded in conventional six-well cell culture plates with O2-impermeable polystyrene membranes and in special plates with gas-permeable membranes(Lumox?,Sarstedt),enabling the experimental separation of mechanotransducive and hypoxic effects that occur concomitantly during OTM.To simulate physiological orthodontic compressive forces,PDL fibroblasts were stimulated mechanically at 2 g·cm?2 for 48 h after 24 h of pre-incubation.We quantified the cell viability by MTT assay,gene expression by quantitative real-time polymerase chain reaction(RT-qPCR)and protein expression by western blot/enzyme-linked immunosorbent assays(ELISA).In addition,PDL-fibroblast-mediated osteoclastogenesis(TRAP+cells)was measured in a 72-h coculture with RAW264.7 cells.The expression of HIF-1α,COX-2,PGE2,VEGF,COL1A2,collagen and ALPL,and the RANKL/OPG ratios at the mRNA/protein levels during PDL-fibroblast-mediated osteoclastogenesis were significantly elevated by mechanical loading irrespective of the oxygen supply,whereas hypoxic conditions had no significant additional effects.The cellular–molecular mediation of OTM by PDL fibroblasts via the expression of various signalling molecules is expected to be predominantly controlled by the application of force(mechanotransduction),whereas hypoxic effects seem to play only a minor role.In the context of OTM,the hypoxic marker HIF-1αdoes not appear to be primarily stabilized by a reduced O2 supply but is rather stabilised mechanically. | Niklas Ullrich Agnes Schroder Jonathan Jantsch Gerrit Spanier Peter Proff Christian Kirschneck | 2019 | International Journal of Oral Science2019，11，4： | 5 |
| 2 | 多核处理器中混合分布式共享存储空间的实时划分技术显示文摘在多核处理器芯片中,分布式共享存储DSM虽然提供了统一的全局寻址的存储空间,但却引入了虚地址向实地址转换的开销,这对性能产生了负面的影响。我们注意到,在并行程序的执行过程中,被处理的数据属性(私有或共享)并不是一成不变的。并行程序中不同的数据具有不同的属性,即使同一数据在程序的不同执行阶段也可能具有不同的属性。本文首先详细地阐述了一种混合式的分布式共享存储空间,支持对共享数据采用全局寻址的虚地址访问而对私有数据采用快速寻址的实地址访问;进而提出了一种针对混合式的分布式共享存储空间的实时划分技术。该技术根据并行程序中数据的属性,在程序运行时,实时地调整和划分分布式共享存储空间。当数据为私有时,通过实地址访问加快数据的访问速度,当数据为共享时则维持虚地址访问,从而减少整个并行程序运行过程中的地址转换开销,提高系统的性能。实际应用程序的实验结果表明,与传统的分布式共享存储空间相比,实时划分的混合式的分布式共享存储空间具有性能优势,性能的提升比例与具体的网络规模、计算规模、并行程序映射方式等有关。在我们的实验中,性能的提升比例最高为13.14%,最低为6.98%。 | 陈小文 陈书明 鲁中海 Axel Jantsch | 2012 | 计算机工程与科学2012，34，7： | 3 |
| 3 | Macrophages regulate salt dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism显示文摘 | Machnik A Neuhofer W Jantsch J | 2009 | Nat Med2009，15，5： | 1 |
| 4 | Inter- and transdisciplinary university: A system approach to education and innovation 显示文摘 | Jantsch E | 1970 | Policy Sciences1970，，： | 1 |
| 5 | Addressing Transient and Permanent Faults in No C with Efficient Fault-tolerant Deflection Router显示文摘 | Feng Chaochao Lu Zhonghai Jantsch A | 2013 | IEEE Transactions on Very Large Scale Integration Systems2013，21，6： | 1 |
| 6 | Hypoxia and hypoxia-inducible factor-1 modulate lopopolysaccharide-induced den dritic cell activation 显示文摘 | Jantsch J Chakravortty D Turza N | 2008 | J Immunol2008，12，3： | 1 |
| 7 | Synthesis of 12-aza analogs of epothilones and (E) - 9,10-dehydroepothilones 显示文摘 | FEYEN F JANTSCH A HAUENSTEIN K | 2008 | Tetrahedron2008，64，34： | 1 |
| 8 | Hypoxia and hypoxia-inducible factor-1 modulate lipopolysaccharide-induced dendritic cell activation and function显示文摘 | Jantsch J Chakravortty D Turza N | 2008 | J Immunol2008，180，： | 1 |
| 9 | A Network on Chip Architecture and Design Methodology显示文摘 | Kumar S Jantsch A Soininen J P | 2002 | In:Proceedings of the IEEE Computer Society Annual Symposium2002，，： | 1 |
| 10 | An automated spectrophotometric system for monitoring buffer capacity in anaerobic digestion processes显示文摘 | Jantsch T.G Mattiasson B | | 0，，17： | 1 |
| 11 | Proteome diversification byadenosine to inosine RNA editing显示文摘 | PULLIRSCH D JANTSCH M F | 2010 | RNA Biol2010，7，2： | 1 |
| 12 | Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism显示文摘 | Machnik A Neuhofer W Jantsch J | 2009 | Nat Med2009，15，5： | 1 |
| 13 | Diffuse Atrazine Pollution in German Aquifers显示文摘 | Tappe W Groeneweg J Jantsch B | 2002 | Biodegradation2002，13，1： | 1 |
| 14 | Anomalies of the refractive index and the optical energy gap of ferroelectric Pb1-xGexTe 显示文摘 | Jantsch W | 1980 | Z Physik B-Condensed Matter1980，40，： | 1 |
| 15 | Detection of intestinal diverticula by double-contrast small bowel enema: Differentiation from other intestinal diverticula显示文摘 | E. Salomonowitz M.D. G. Wittich P. Hajek H. Jantsch H. Czembirek | 1983 | Gastrointestinal Radiology1983，，1： | 1 |
| 16 | High-resolution spectroscopy of Er3+ ions in 6H SiC显示文摘 | KOZANECKI A GLUKHANYUK V JANTSCH W | 2003 | Materials Science and Engineering B2003，105，： | 1 |
| 17 | Occurrence and removal of selected organic micropollutants at mechanical, chemical and advanced wastewater treatment plants in Norway显示文摘 | Vogelsang C Grung M Jantsch T G | 2006 | Water Research2006，40，19： | 1 |
| 18 | Growth kinetics of diethylnitrosmine-induced,enzyme-deficient'preneoplastic'liver cell populations in vivo and in vitro显示文摘 | Rabes H M Scholze P Jantsch B | 1972 | Cancer Res1972，32，11： | 1 |
| 19 | Effect of ternary Al, Ni additions on hydrogen absorption behaviour of Ti–45Nb alloys显示文摘 | B. Dutta T. Keller M. Rettenmayr U. Jantsch D.F. Lupton | 2004 | Materials Science & Engineering A2004，，1： | 1 |
| 20 | Cortical repre- sentation of experimental tooth pain in humans显示文摘 | Jantsch H H Kemppainen P Ringler R | 2005 | Pain2005，118，3： | 1 |
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