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| 1 | Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis显示文摘Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated cholangitis.For steroid-dependent disease,azathioprine has been used for maintenance of remission.Mycophenolate mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte production.Introduction of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse events.The patient was managed without a biliary stent.However,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per day.In the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the steroids.Mycophenolate mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis. | Jamie B Sodikoff Steven A Keilin Sheila J Bharmal Melinda M Lewis Gottumukkala S Raju Field F Willingham | 2012 | World Journal of Gastroenterology2012，18，18： | 6 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Characterization of a unique ethanologenic yeast capableof fermenting galactose显示文摘 | Jamie R Rodney J Bothast John N S Shawn D M | 2004 | Enzyme and Microbial Technology2004，35，： | 1 |
| 4 | The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model 显示文摘 | Ottesen JL Nilsson P Jami J | 1994 | Diabetologia1994，37，12： | 1 |
| 5 | Body composition at high altitude:a randomized placebo-controlled trial of dietary carbohydrate supplementation显示文摘 | Jamie H Macdonald Samuel J Oliver Kelly Hillyer | 2009 | Am J Clin Nutr2009，90，： | 1 |
| 6 | Characterization of chicken TNFR superfamily decoy receptors,DcR3 and osteoprotegerin显示文摘 | Jamie J Alan L | 2003 | Biochem Biophys Res Commun2003，307，： | 1 |
| 7 | A comparative study of tolerance analysis methods显示文摘 | HEN Zhengshu GAURAV A JAMI J S | 2005 | Journal of Computing and Information Science in Engineering2005，5，3： | 1 |
| 8 | Wear behaviour of interpenetrating alumina–copper composites显示文摘 | Jami Winzer Ludwig Weiler Jeanne Pouquet Jürgen R?del | 2011 | Wear2011，，11： | 1 |
| 9 | The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model显示文摘 | Ottesen JL Nilsson P Jami J | 1994 | Diabetologia1994，37，： | 1 |
| 10 | The potential immunogenieity of human insulin and insulin analogues evaluated in a transgenic mouse mede显示文摘 | Ottesen JL Nilsson P Jami J | 1994 | Diabetologia1994，37，12： | 1 |
| 11 | Characterazation of a coronavirus isolated from a diarrheic foal显示文摘 | Guy Jamie J Breslin | 2000 | Journal of Clinical Microbiology2000，38，12： | 1 |
| 12 | Ambrisentan显示文摘 | JAMIE D C SUSAN J K | 2008 | Drugs2008，68，15： | 1 |
| 13 | How metalliferous brines line Mexi- can epithermal veins with silver显示文摘 | Jamie J W Stuart F S Barry S | 2013 | Scientific Reports2013，3，： | 1 |
| 14 | Paxe expressed in osteoeytes inhibits canonical Wnt signaling 显示文摘 | Jami A Gadi J Lee M J | 2013 | Mol Ceils2013，35，4： | 1 |
| 15 | Seafood Biopreservation By Lactic Acid Bacteria-a Review显示文摘 | Mahdi Ghanbari Mansooreh Jami Konrad J Domig | 2013 | Lwt-Food Science and Technology2013，，2： | 1 |
| 16 | Imine reductases : a comparison of glutamate dehydrogenase to ketimine re- ductases in the brain 显示文摘 | Hallen A Jamie J F Copper A J L | 2014 | Neurochem Res2014，39，3： | 1 |
| 17 | Natural fiber composites the potential for the Asian markets显示文摘 | Richardson Melvin O W Madera- Santana Tomas J Haque Jamie | 1998 | Progress in Rubber and Plastics Technology1998，14，3： | 1 |
| 18 | Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells显示文摘 | Ivanov Andrei Beers Stephen A Walshe Claire A Honeychurch Jamie Alduaij Waleed Cox Kerry L Potter Kathleen N Murray Stephen Chan Claude H T Klymenko Tetyana Erenpreisa Jekaterina Glennie Martin J Illidge Tim M Cragg Mark S | 2009 | Journal of Clinical Investigation2009，，8： | 1 |
| 19 | From Sitting Principles to Sitting Practices:A Case Study of Discord among Trust,Equity and Community Participation显示文摘 | Jamie W Baxter John D Eyles Susan J Elliott | 1999 | Journal of Environmental planning and Management1999，42，4： | 1 |
| 20 | Cold weather placement of RCC显示文摘 | Choi Ying- Kit Neighbors J Douglas Reichler Jamie D | 2003 | Journal of Ma- terials in Civil Engineering2003，15，2： | 1 |
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