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| 1 | Insulin resistance,adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C显示文摘AIM:to analyze adipokine concentrations,insulin resistance and hepatic expression of suppressor of cytokine signaling 3(SOCS-3)in patients with chronic hepatitis C genotype 1 with normal body weight,glucose and lipid profile.METHODS:The study group consisted of 31 patients with chronic hepatitis C and 9 healthy subjects.Total levels of adiponectin,leptin,resistin,visfatin,omentin,osteopontin and insulin were measured using an ELISA kit.The hepatic expression of SOCS-3 was determined by the use of the reverse transcription polymerase chain reaction method.RESULTS:Homeostasis model assessment for insulin resistance(HOMA-IR)values were significantly higher in hepatitis C virus(HCV)infected patients without metabolic disorders compared to healthy controls(2.24 vs 0.59,P=0.0003).Hepatic steatosis was observed in 32.2%of patients with HCV infection and was found in patients with increased HOMA-IR index(2.81 vs1.99,P=0.05)and reduced adiponectin level(5.96vs 8.37,P=0.04).Inflammatory activity(G≥2)was related to increased osteopontin concentration(34.04vs 23.35,P=0.03).Advanced liver fibrosis(S≥2)was associated with increased levels of omentin and osteopontin(436.94 vs 360.09,P=0.03 and 32.84 vs20.29,P=0.03)and reduced resistin concentration(1.40 vs 1.74,P=0.047).No correlations were reported between adipokine profile,HOMA-IR values and hepatic expression of the SOCS-3 gene.CONCLUSION:We speculated that no relationship between adipokines and HOMA-IR values may indicate that HCV can induce insulin resistance itself.Some adipokines appear to be biochemical markers of steatosis,inflammation and fibrosis in patients with chronic HCV infection. | Kamila Wójcik Elzbieta Jabonowska Aleksandra Omulecka Anna Piekarska | 2014 | World Journal of Gastroenterology2014，20，30： | 8 |
| 2 | Studies of mitotic and centromeric abnormalities in roberts syndrom:Implications for a defect in the mitotic mechanism显示文摘 | Tuck C M Cusano R | 1991 | Chromosoma1991，100，： | 1 |
| 3 | Genomic,cDNA and embryonic expression analysis of zebrafish IRF6,the gene mutated in the human oral clefting disorders Van der Woude and popliteal pterygium syndromes显示文摘 | BEN J JABS E W CHONG S S | 2005 | Gene Expr Patterns2005，5，： | 1 |
| 4 | Local generation of C-reactive protein in diseased coronary artery venous bypass grafts and normal vascular tissue显示文摘 | Jabs W J Theissing E Nitschke M | 2003 | Circulation2003，108，12： | 1 |
| 5 | Association between clinical disease activity and Epstein-Barr virus reactivation in MS 显示文摘 | Wandinger KP Jabs W Siekhaus A | 2000 | Neurology2000，55，： | 1 |
| 6 | Qualitative analysis of membrane curtents in glial cells from normal and gliotic tissue in situ: down-regulation of Na+ current and lack of P2 purinergic responses显示文摘 | Jabs R Paterson I A Walz W | 1997 | Neuroscience1997，81，3： | 1 |
| 7 | Patients at risk for development of posttransplant lymphoproliferative disorder:plasma versus peripheral blood mononuclear cells as material for quantification of Epstein-Barr viral load by using real-time quantitative polymerase chain reaction显示文摘 | Wagner HJ Wessel M Jabs W | 2001 | Transplantation2001，72，6： | 1 |
| 8 | Kidney as a second site of human C-reactive protein formation in vivo 显示文摘 | Jabs W J Logering B A Gerke P | 2003 | Eur J Immunology2003，33，： | 1 |
| 9 | The kidney as a second site of human all c-reactive protein forn ation in vivo显示文摘 | Jabs W I Logering B A Gerke P | 2003 | Eur J lmmunol2003，33，1： | 1 |
| 10 | Association between clinical disease activity and Epstein-Barr virus reactivation in MS显示文摘 | WANDINGER K JABS W SIEKHAUS A | 2000 | Neurology2000，55，2： | 1 |
| 11 | Qualitative analysis of membrane currents in glial cells from normal and gliotic tissuein situ: downregulation of Na + cunrrent and lack of P2 purinergic responses 显示文摘 | Paterson IA Walz W | 1997 | Neuroscience1997，81，9： | 1 |
| 12 | Development of flow injection spectrophotometric methods for the determination of free available chlorine and total available chlorine:comparative study显示文摘 | Saad B Wai W T Jab MS | | 0，，1： | 1 |
| 13 | Brachial plexus tumors--neurosurgical treatment显示文摘 | Jarmundowicz W Jab(n)o(n)ski P Zaluski R | 2002 | Neurol Neurochir Pol2002，36，5： | 1 |
| 14 | The Mechanical Behaviour of Corrugated-core Sandwich Panels显示文摘 | RE JAB N R M CANTWELL W J | 2013 | Composites Part B: Engineering2013，47，： | 1 |
| 15 | TCOF1 mutations excluded from a role in other first and second branchial arch - related disorders显示文摘 | SPLENDORE A PASSOS BUENO M R JABS E W | 2002 | Am J Med Genet2002，111，3： | 1 |
| 16 | Association between clinical disease activity and Epstein-Barr virus reactivation in MS显示文摘 | Jabs W Siekhaus A | 2000 | Neurology2000，55，2： | 1 |
| 17 | Local generation of C-reactive protein in diseased coronary artery venous bypass grafts and normal vascular tissue显示文摘 | Jabs W J Theissing E Nitschke M | | 0，，12： | 1 |
| 18 | Facters Affecting Growth after Renal Transplantaton显示文摘 | HARMON W E JABS K | 1992 | J Am Soc Nephro1992，12，： | 1 |
| 19 | Genomic, cDNA and embryonic expression analysis of zebrafish IRF6, the gene mutated in the human oral clefting disorders Van der Woude and popliteal pterygium syndromes 显示文摘 | Ben J Jabs E W Chong S S | 2005 | Gene Expr Patterns2005，5，5： | 1 |
| 20 | The kidney as a second site of human c-reactive protein formation in vivo 显示文摘 | JABS W J LOGERING B A GARKE P | 2003 | Eur J Immunol2003，33，1： | 1 |
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