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| 1 | 高龄对男性生育力的影响显示文摘在过去的几十年里,现代社会的压力和期望使得育龄夫妇生育年龄总体推迟。已知女性在临近40岁时卵母细胞的产生将会明显减少,而高龄对男性精子生成能力的影响还知之甚少。男性生育年龄无明确限制,因而高龄对男性生育能力的影响还不完全清楚。本文将就目前已知的高龄对男性精子质量、生育能力和子代健康的影响进行综述,希望能在医生就男性推迟生育及高龄相关的风险咨询时起到一定的指导作用。 | Jason R Kovac Josephine Addai Ryan P Smith Robert M Coward Dolores J Lamb Larry I Lipshultz | 2013 | Asian Journal of Andrology2013，15，6： | 12 |
| 2 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 3 | Histopathological regression grading matches excellently with local and regional spread after neoadjuvant therapy of rectal cancer显示文摘 | Sefer Elezkurtaj Lutz Moser Jan Budczies Alice Josephine Müller Hendrik Bl?ker Heinz Johannes Buhr Manfred Dietel Martin Kruschewski | 2013 | Pathology - Research and Practice2013，，7： | 2 |
| 4 | Sex determination in mammalian germ cells显示文摘细菌细胞是精子和卵母细胞的先锋并且因此为种的幸存是批评的。在哺乳动物,他们在胎儿的生活期间被指定,移居到发展中的性腺然后经历他们在期间被指示的一个批评时期,到,由身体采用适当性命运。在一个胎儿的卵巢,细菌房间进入成熟分裂并且,在一个胎儿的睾丸承诺卵子发生,他们避免入口进成熟分裂并且相反经历有丝分裂的拘捕并且向精子发生成熟。这里,我们讨论我们到目前为止对细菌房间的性特定的区别的规定知道的,就体的房间,以及在细菌房间以内的批评内在的变化生产的外来的分子的暗示而言。这评论几乎专门集中于我们这些事件的理解在老鼠模型。 | Cassy M Spiller Josephine Bowles | 2015 | Asian Journal of Andrology2015，17，3： | 2 |
| 5 | Comparison of reducibility and stability of alumina-supported Ni catalysts prepared by impregnationand co-precipitation 显示文摘 | Li G H Hu L J Josephine M Hill | 2006 | Appl Catal A2006，301，： | 1 |
| 6 | Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase显示文摘 | Aino Soro-Paavonen Wei-Zeng Zhang Kylie Venardos Melinda T Coughlan Emma Harris David CK Tong Daniella Brasacchio Karri Paavonen Jaye Chin-Dusting Mark E Cooper David Kaye Merlin C Thomas Josephine M Forbes | 2010 | Journal of Hypertension2010，，4： | 1 |
| 7 | Simultaneousdetermination of nine intense sweeteners in foodstuffs by highperformance liquid chromatography and evaporative light scatteringdetection: development and single laboratory validation显示文摘 | WASIK A JOSEPHINE M C BUCHGRABER M | 2007 | Journal ofChromatograph A2007，1157，： | 1 |
| 8 | Toughened polyester matrices for advanced composites显示文摘 | Sharmila R Josephine Premkumar S Alagar M | 2007 | Journal of Applied Polymer Science2007，103，1： | 1 |
| 9 | Model- ling the transition towards a green economy in South Africa 显示文摘 | Josephine K Musango Alan C Brent Andrea M Bassi | 2014 | Technological Forecasting & Social Change2014，，87： | 1 |
| 10 | Prevalence of Sleep Problem in Hong Kong Primary School Children: A Community-Based Telephone Survey 显示文摘 | Danielk N G KA-LI Kwor Josephine M Cheug | 2005 | Chest2005，126，3： | 1 |
| 11 | Principles of good practice for budget impact analysis : report of the ISPOR task force on good research practices-budget impact analysis 显示文摘 | JOSEPHINE A M SEAN D S LIEVEN A | 2007 | Val- ue Health2007，10，5： | 1 |
| 12 | Philippine population database at nine microsatellite loci for forensic and paternity applications显示文摘 | SATURNINA C H JOSEPHINE Y C A LLANCHRIS M F | 1999 | Forensic Sci Int1999，101，： | 1 |
| 13 | Selective dehydrogenation of isobutane over supported Pt/ Sn catalysts 显示文摘 | Cortright Randy D Hill Josephine M Dumesic James A | 2000 | Catalysis Today2000，55，3： | 1 |
| 14 | Patterns of skin manifestations and their relationships with CD4^+ counts among HIV/AIDS patients in Cameroon显示文摘 | Josephine M Issac E George A | 2006 | Int J Dermatol2006，45，3： | 1 |
| 15 | Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy显示文摘 | Josephine M Forbes Mark E Cooper Vicki Thallas | 2002 | Diabetes2002，51，11： | 1 |
| 16 | Research Methods Education forPublic Sector Careers:The Challenge of Utilization 显示文摘 | Laplante Josephine M | 1989 | Pol-icy Studies Review1989，，8： | 1 |
| 17 | Dose calcala- tion using megavoltage cone-beam CT 显示文摘 | OLIVER M JOSEPHINE C MICHELE A | 2007 | Int J Rad Bio Ph2007，67，7： | 1 |
| 18 | Accreditation of postgraduate medical education in the United States and Canada: a comparison of two systems显示文摘 | Josephine MCassie Judith SArmbruster M IanBowmer David CLeach | 2002 | Medical Education2002，，： | 1 |
| 19 | Temporal renal expression of angiogenic growth factors and their receptors in experimental diabetes:rele of the renin-angiotensin system显示文摘 | Bishoy Rizkalla Josephine M Forbes | 2005 | Journal of Hypertension2005，23，： | 1 |
| 20 | Oxidative stress as a major culprit in kidney disease in diabetes显示文摘 | Josephine M Coughlan MT Cooper ME | | Diabe- tes0，57，6： | 1 |
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