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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Red River barrier and Pleistocene climatic fluctuations shaped the genetic structure of Microhyla fissipes complex (Anura: Microhylidae) in southern China and Indochina显示文摘 | Zhi-Yong YUAN Chatmongkon SUWANNAPOOM Fang YAN Nikolay A. POYARKOV JR Sang Ngoc NGUYEN Hong-man CHEN Siriwadee CHOMDEJ Robert W, MURPHY Jing CHE | 2016 | Current Zoology2016，62，6： | 11 |
| 3 | Alcohol use disorders and current pharmacological therapies: the role of GABAA receptors显示文摘 | Jing LIANG Richard W OLSEN | 2014 | Acta Pharmacologica Sinica2014，35，8： | 8 |
| 4 | Epidemiological serosurvey of Hepatitis B in China—Declining HBV prevalence due to Hepatitis B vaccination显示文摘 | Xiaofeng Liang Shengli Bi Weizhong Yang Longde Wang Gang Cui Fuqiang Cui Yong Zhang Jianhua Liu Xiaohong Gong Yuansheng Chen Fuzhen Wang Hui Zheng Feng Wang Jing Guo Zhiyuan Jia Jingchen Ma Huaqing Wang Huiming Luo Li Li Shuigao Jin Stephen C. Hadler Yu W | 2009 | Vaccine2009，，47： | 7 |
| 5 | Effect of coronary bifurcation angle on clinical outcomes in Chinese patients treated with crush stenting: a subgroup analysis from DKCRUSH-1 bifurcation study显示文摘背景分叉角度可以影响压碎 stenting 的临床的结果。我们寻求了比较高度(60 ( | CHEN Shao-liang ZHANG Jun-jie YE Fei CHEN Yun-dai FANG Wei-yi WEI Meng HE Ben SUN Xue-wen YANG Song CHEN Jin-guo SHAN Shou-jie TIAN Nai-liang LI Xiao-bo LIU Zhi-zhong KAN Jing Lee Michael Kwan Tak W | 2009 | Chinese Medical Journal2009，，4： | 5 |
| 6 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 7 | Proliferation and pluripotency potential of ectomesenchymal cells derived from first branchial arch显示文摘 | Lin Y Yan Z Liu L Qiao J Jing W Wu L Chert X Li Z Tang W Zheng X Tian W | 2006 | 中国生物学文摘2006，20，5： | 3 |
| 8 | Clinical outcome after management of unprotected left main in-stent restenosis after bare metal or drug-eluting stents显示文摘也的背景培植赤裸的金属 stent (BMS ) 或 drug-eluting stent (DES ) 与没有防卫的左主要狭窄(UPLMS ) 为病人在每天实践被使用了。仍然有数据 regading 的缺乏 UPLMS in-stent 狭窄(ISR ) 的随后的结果。在 stenting 被包括以后,现在的学习与 UPLMS ISR 在 BMS 或 DES.Methods 病人的培植以后在 determing 瞄准了 UPLMS ISR 病人的临床的结果。主要端点是累积主要不利心脏的事件(向) ,包括心脏的死亡,心肌的梗塞(Ml ) ,和目标容器 revascularization (TVR ).Results UPLMS ISR 率 14.8%(n=73, 15.7% 在 BMS 以后, 14.5% 为 DES ) 在以后平均(3.89 | CHEN Shao-liang XU Bo Gary Mintz YE Fei ZHANG Jun-jie KAN Jing SUN Xue-wen ZHANG Ai-ping CHEN Jin-guo QIAN Jun Kwan Tak W | 2010 | Chinese Medical Journal2010，，7： | 3 |
| 9 | Coronary bifurcation angle from 3-D predicts clinical outcomes after stenting bifurcation lesions显示文摘 | CHEN Shao-liang Teguh Santoso ZHANG Jun-jie YE Fei XU Ya-wei FU Qiang KAN Jing Chitprapai Paiboon ZHOU Yong DING Shi-qing Tak W Kwan | 2012 | Chinese Medical Journal2012，，12： | 2 |
| 10 | A new SPD process for spheroidal cast iron显示文摘 | Zhao X Jing T F Gao Y W | 2004 | Materials Letters2004，58，： | 1 |
| 11 | Highly sensitive and specific microRNA expression profiling using BeadArray technology显示文摘 | CHEN Jing LOZACH J GARCIA E W | 2008 | Nucleic Acids Res2008，36，14： | 1 |
| 12 | Towards a structure-function analysis of bovine lactoferricin and related tryptophan and argini-necontaining peptides 显示文摘 | Vogel H J Schibli D J Jing W G | 2002 | Biochemistry and Cell Biology2002，80，1： | 1 |
| 13 | Large-scale variability of wind erosion mass flux rates at Owens Lake显示文摘 | Gillette D A Fryrear D W Jing B X | 1997 | Journal of Geophysical Research1997，102，25： | 1 |
| 14 | Metal porphyrin/phenyltrimethylammonium tribromidc:High efficient catalysts for coupling reaction of CO2 and epoxides显示文摘 | JIN L L JING H W CHANG T | 2007 | Journal of Molecular Catalysis(A) : Chemical2007，261，： | 1 |
| 15 | Simultaneous determination of artifi- cial sweeteners, preservatives, caffeine, theobromine and theophylline in food and pharmaceutical preparations by ion chromatography 显示文摘 | Qingchuan C Jing W | 2001 | J Chromatogr A2001，937，12： | 1 |
| 16 | Characterisations of Derivations on some Operator Algebras显示文摘 | Jing W Lu S Li P | | 0，，： | 1 |
| 17 | Work-related pesticide poi- soning among farmers in two villages of Southern China: a cross-sec- tional survey 显示文摘 | Zhang X J Zhao W Y Jing R W | 2011 | BMC Public Health2011，11，6： | 1 |
| 18 | A full multigrid method for linear complementarity problems arising from elastic normal, contact problems 显示文摘 | ZHAO Jing VOLLEBREGT E A H OOSTERLEE C W | 2014 | Mathematical Modelling and Analysis2014，19，2： | 1 |
| 19 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 20 | Cervical corpectomy with preserved posterior vertebral wall for cervical spondylotic myelopathy: a randomized control clinical study显示文摘 | Ying Z Xinwei W Jing Z | 2007 | Spine2007，32，14： | 1 |
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