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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Early results with the new internal fixator systems LCP and LISS: prospective study 显示文摘 | HERNANZ G Y DIAZ M A JARA S F | 2007 | Acta Orthop Belg2007，73，1： | 1 |
| 3 | Production of hydrogen by partial oxidation of methanol over ZnO - supported palladium catalysts prepared by microemulsion technique显示文摘 | Agrell J Germani G Jaras S G | 2003 | Appl catal A2003，242，2： | 1 |
| 4 | A High Index of Suspicion: The Key to an Early Diagnosis of Wilson’s Disease in Childhood显示文摘 | Icíar Sánchez-Albisua Teresa Garde Loreto Hierro Carmen Camarena Esteban Frauca Angela de la Vega María Carmen Díaz Javier Larrauri Paloma Jara | 1999 | Journal of Pediatric Gastroenterology & Nutrition1999，，2： | 1 |
| 5 | Production of hydrogen by partial oxidation of methanol over ZnO-supported palladium catalysts prepared by microemulsion technique显示文摘 | Agrell J Germani G Jaras S G | 2003 | Appl Catal A2003，242，2： | 1 |
| 6 | Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neuro- toxicity 显示文摘 | Leskela S Jara C Leandro - Garcfa LJ | 2011 | Pharmacogenomics J2011，11，： | 1 |
| 7 | MR urography显示文摘 | HUSSAIN S O′MALLEY M JARA H | 1997 | Magn Reson Imaging Clin N Aam1997，5，1： | 1 |
| 8 | Nitrogen deficiency detection using reflected short-wave radiation from irrigated corn canopies显示文摘 | Jaraes S S Gary E V | 1996 | Agronomy Journal1996，88，： | 1 |
| 9 | Catalytic materials for high-temperature combustion显示文摘 | JARAS S G MENON P G | 1993 | Catal Rev Sci Eng1993，35，3： | 1 |
| 10 | Production of hydrogen by partial oxidation of methanol over ZnO- supported palladium catalysts prepared by microemulsion technique 显示文摘 | AGRELL J GERMANI G JARAS S G | 2003 | Applied Catalysis A: General2003，242，2： | 1 |
| 11 | On the interaction of vanadium and nickel compounds with cracking catalyst 显示文摘 | Pompe R Jaras S Vannerberg N G | 1984 | Applied Catalysis1984，13，1： | 1 |
| 12 | MR urography显示文摘 | Hussain S O'Mallery M Jara H | 1997 | Magn Reran Imaging Clin N Am1997，5，1： | 1 |
| 13 | Value of time sensitivity to model swcifieation 显示文摘 | Gaudry M J 1 Jara - Diaz S R Ortuzar J de D | 1989 | Transportation Research1989，23，： | 1 |
| 14 | Vascular damage in chronic kidney disease显示文摘 | Jara A Mezzano S | 2008 | Rev Med Chil2008，136，11： | 1 |
| 15 | Early results with the new internal fixator systems LCP and LISS:prospective study显示文摘 | Hernanz G Y Diaz M A Jara S F | | 0，，01： | 1 |
| 16 | Polymorphisms in cytochromes P4502C8 and 3A5 are associated with paclitaxel neurotoxicity 显示文摘 | Leskel S Jara C Leandro-Garcia L | 2010 | PharmacogenoaticsJ2010，11，2： | 1 |
| 17 | Polymorph- isms in cytochromes P450 2c8 and 3A5 are associated with paclitaxel neurotoxieity显示文摘 | Leskela S Jara C Leandro-Garcia L J | 2011 | Pharmacogenomics J2011，11，2： | 1 |
| 18 | Preparation of carbon supported Pt and PtRu nanoparticles from microemulsion electrocatalysts for fuel cell applications显示文摘 | ROJAS S GARCIA F J JARAS S | 2005 | Applied Catalysis A:General2005，285，： | 1 |
| 19 | Effects of hot water extraction and fungal decay on wood crystalline cellulose structure 显示文摘 | Howell C Hastrup A C S Jara R | 2011 | Cellulose2011，18，： | 1 |
| 20 | Determination of phthalates in water sample using polystyrene solid-phase extraction and liquid chromatography quantification显示文摘 | JARA S LYSEBO C GREIBROKK T | 2000 | Analytica Chimica Acta2000，407，： | 1 |
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