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| 1 | Ischemic Stroke Subtypes: A Population-Based Study of Functional Outcome, Survival, and Recurrence显示文摘 | George W. Petty Robert D. Brown Jack P. Whisnant JoRean D. Sicks W. Michael O’Fallon David O. Wiebers | 2000 | Stroke: Journal of the American Heart Association2000，，5： | 2 |
| 2 | From symptom onset to a diagnosis of amyotrophic lateral sclerosis/motor neuron disease(ALS/MND):experiences of people with ALS/MND and family carers-a qualitative study显示文摘 | O'Brien MR Whitehead B Jack BA | 2011 | Amyotroph Lateral Scler2011，12，2： | 1 |
| 3 | Frequency of Allogeneic Hematopoietic Cell Transplantation Among Patients With High- or Intermediate-Risk Acute Myeloid Leukemia in First Complete Remission显示文摘 | Raya Mawad Ted A. Gooley Vicky Sandhu Jack Lionberger Bart Scott Brenda M. Sandmaier Paul O’Donnell Pamela S. Becker Stephen Petersdorf Kathleen Shannon Dorcy Paul Hendrie Mohamed L. Sorror Roland B. Walter H. Joachim Deeg Frederick R. Appelbaum Elihu H. | 2013 | Journal of Clinical Oncology2013，，31： | 1 |
| 4 | Tumor necrosis factor-ablocking agent as a treatment for nephrotic syndrome 显示文摘 | Daveh D Shemesh O Jack Y | 2004 | Pediatr Nephrol2004，19，8： | 1 |
| 5 | Frequency of microsatellite sequencesin rice(Oryza sativa L)显示文摘 | PANAUD O CHEN X JACK P I | 1995 | Theoretical and Applied Genetics1995，87，： | 1 |
| 6 | Mannose-binding lee- tin binds to a range of clinically relevant microorganisms and promotes complement deposition显示文摘 | Neth O Jack DL Dodds AW | 2000 | Infect Immun2000，68，2： | 1 |
| 7 | Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notchl proteolysis and nuclear translocation with relative preservation of notchl signaling 显示文摘 | Berezovska O Jack C McLean P | 2000 | J Neurochem2000，75，2： | 1 |
| 8 | Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition显示文摘 | Neth O Jack DL Dodds AW | 2000 | Infect Immun2000，68，2： | 1 |
| 9 | Evidence of seroconversion to SBV in camelids显示文摘 | Jack C Anstaett O Adams J | 2012 | Vet Rec2012，170，： | 1 |
| 10 | Neonatal ovarian cysts: pathogenesis, diagnosis and management 显示文摘 | Sandra S Jack O Haler | 1997 | Pediatr Radiol1997，27，： | 1 |
| 11 | Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD显示文摘 | XU Y JACK CR Jr O'BRIEN PC | 2000 | Neurology2000，54，9： | 1 |
| 12 | Reduced Risk of Restenosis in Small Vessels and Reduced Risk of Myocardial Infarction in Long Lesions With the New Thin-Strut TAXUS Liberté Stent显示文摘 | Mark A. Turco John A. Ormiston Jeffrey J. Popma Jack J. Hall Tift Mann Louis A. Cannon Mark W.I. Webster Gregory J. Mishkel Charles D. O’Shaughnessy Thomas F. McGarry Lazar Mandinov Keith D. Dawkins Donald S. Baim | 2008 | JACC: Cardiovascular Interventions2008，，6： | 1 |
| 13 | Central nervous system lymphoma: histologik types and CT appearance 显示文摘 | Jack CR O'Neill BP Banks PM | 1988 | Radiology1988，167，1： | 1 |
| 14 | Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition显示文摘 | Jack DL Dodds AW | 2000 | Infect Immun2000，68，2： | 1 |
| 15 | Type of admission is associated with outcome of spontaneous subarachnoid hemorrhage显示文摘 | Doniel Drazin Jack Rosner Miriam Nu?o Michael J. Alexander Wouter I. Schievink David Palestrant Patrick D. Lyden Chad Miller | 2015 | Int J Stroke2015，，： | 1 |
| 16 | Effect of inflammatory bowel disease treatments on patients with diabetes mellitus显示文摘As medical care progresses and the number of patients with chronic conditions increases there is the inevitable challenge of managing patients with multiple comorbidities.Inflammatory bowel disease(IBD)is an umbrella term for are inflammatory conditions affecting the gastrointestinal tract,the two most common forms being Ulcerative Colitis and Crohn’s disease.These diseases,usually diagnosed in young adults,exhibit a relapsing and remitting course and usually require longterm treatment.IBD can be treated with a number of topical and systemic treatments.We conducted a review of the current published evidence for the effects these medications can have on diabetes mellitus(DM)and glycaemic control.Searches were conducted on medline and embase with a timeframe from 1947(the date from which studies on embase are recorded)to November 2020.Suitable publications were selected and reviewed.Current evidence of the impact of aminosalicylates,corticosteroids,thiopurines,and biologic agents was reviewed.Though there was limited evidence for certain agents,IBD medications have been shown to have an effect of DM and these effects should be considered in managing patients with dual pathologies.The effects of steroids on blood sugar control is well documented,but consideration of other agents is also important.In patients requiring steroids for Ulcerative Colitis,locally acting steroid agents delivered rectally may be preferred to minimise side effects in those with distal bowel Ulcerative Colitis.A switch to other agents should be considered as soon as possible in people with diabetes to limit the impact on glycaemic control.5-aminosalicylates appear to play a role in the reduction of hemoglobin A1c(HbA1c),although the literature suggests these may be falsely low readings.Consequently,monitoring of people with diabetes on these agents may require daily monitoring of capillary blood sugars rather than relying simply on HbA1c;for example fructosamine performed 3-6 monthly,although this risks missing the rise in readings.There is only limited evidence of the effects of thiopurines on diabetes and further investigation is needed into the possible relationship between them.However,given the current available evidence it may be preferable to commence patients with diabetes on thiopurines as soon as possible,whilst also monitoring for side effects such as pancreatitis.There appears to be more evidence supporting a link between tumor necrosis factor-αinhibitors and DM.Both infliximab and adalimumab have evidence suggesting that both can cause reduced blood sugar levels.Further studies on the effects of the various biological agents mentioned are required alongside any novel biologic therapy and the impact of dual biologic therapy in the future. | Joshua Ashley Jack Bower Lauren O'Flynn Rakhi Kakad David Aldulaimi | 2021 | World Journal of Diabetes2021，12，8： | 1 |
| 17 | Tumor Necrosis Factor α Is Toxic to Embryonic Mesencephalic Dopamine Neurons显示文摘 | Susan O McGuire Zao Dung Ling Jack W Lipton Caryl E Sortwell Timothy J Collier Paul M Carvey | 2001 | Experimental Neurology2001，，2： | 1 |
| 18 | Macular hole surgery with internal-limiting membrane peeling and intravitreous air显示文摘 | Donald W Park Jack O Sipperley Scott R Sneed Pravin U Dugel Jaclin Jacobsen | 1999 | Ophthalmology1999，，7： | 1 |
| 19 | A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis显示文摘Several developmental stages of spermatogenesis are transcriptionally quiescent which presents major challenges associated with the regulation of gene expression. Here we identify that the zygotene to pachytene transit!on is not only associated with the resumption of transcription but also a wave of programmed mRNA degradation that is essential for meiotic progress!on. We explored whether terminal uridydyl transferase 4-(TUT4-) or TUT7-mediated 3' mRNA uridylation contributes to this wave of mRNA degradation during pachynema. Indeed, both TUT4 and TUT7 are expressed throughout most of spermatogenesis, however, loss of either TUT4 or TUT7 does not have any major impact upon spermatogenesis. Combined TUT4 and TUT7 (TUT4/7) deficiency results in embryonic growth defects, while conditional gene targeting revealed an essential role for TUT4/7 in pachytene progression. Loss of TUT4/7 results in the reduction of miRNA, piRNA and mRNA 31 uridylation. Although this reduction does not greatly alter miRNA or piRNA expression, TUT4/7-mediated uridylation is required for the clearanee of many zygotene-expressed transcripts in pachytene cells. We find that TUT4/7-regulated transcripts in pachytene spermatocytes are characterized by having long 3Z UTRs with length-adjusted enrichment for AU-rich elements. We also observed these features in TUT4/7-regulated maternal transcripts whose dosage was recently shown to be essential for sculpting a functional maternal transcriptome and meiosis. Therefore, mRNA 3Z uridylation is a critical determinant of both male and female germline transcriptomes. In conclusion, we have identified a novel requirement for 3' uridylation-programmed zygotene mRNA clearanee in pachytene spermatocytes that is essential for male meiotic progression. | Marcos Morgan Yuka Kabayama Christian Much Ivayla Ivanova Monica Di Giacomo Tatsiana Auchynnikava Jack Michael Monahan Dimitrios Michael Vitsios Lina Vasiliauskaite Stefano Comazzetto Juri Rappsilber Robin Campbell Allshire Bo Torben Porse Anton James Enright Donal O'Carroll | 2019 | Cell Research2019，29，3： | 1 |
| 20 | Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition显示文摘 | Neth O Jack DL Dodds AW | 2000 | Infect Immun2000，68，2： | 1 |
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