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| 1 | Acute retinal arterial ischemia显示文摘Acute retinal arterial ischemia,which includes transient monocular vision loss(TMVL),branch retinal artery occlusion(BRAO),central retinal artery occlusion(CRAO)and ophthalmic artery occlusion(OAO),is most commonly the consequence of an embolic phenomenon from the ipsilateral carotid artery,heart or aortic arch,leading to partial or complete occlusion of the central retinal artery(CRA)or its branches.Acute retinal arterial ischemia is the ocular equivalent of acute cerebral ischemia and is an ophthalmic and medical emergency.Patients with acute retinal arterial ischemia are at a high risk of having further vascular events,such as subsequent strokes and myocardial infarctions(MIs).Therefore,prompt diagnosis and urgent referral to appropriate specialists and centers is necessary for further work-up(such as brain magnetic resonance imaging with diffusion weighted imaging,vascular imaging,and cardiac monitoring and imaging)and potential treatment of an urgent etiology(e.g.,carotid dissection or critical carotid artery stenosis).Since there are no proven,effective treatments to improve visual outcome following permanent retinal arterial ischemia(central or branch retinal artery occlusion),treatment must focus on secondary prevention measures to decrease the likelihood of subsequent ischemic events. | Michael Dattilo Nancy J.Newman Valérie Biousse | 2018 | Annals of Eye Science2018，，1： | 3 |
| 2 | Poly(ethylene glycol)hydrogel elasticity influences human mesenchymal stem cell behavior显示文摘Coordinated investigations into the interactions between biologically mimicking(biomimetic)material constructs and stem cells advance the potential for the regeneration and possible direct replacement of diseased cells and tissues.Any clinically relevant therapies will require the development and optimization of methods that mass produce fully functional cells and tissues.Despite advances in the design and synthesis of biomaterial scaffolds,one of the biggest obstacles facing tissue engineering is understanding how specific extracellular cues produced by biomaterial scaffolds influence the proliferation and differentiation of various cell sources.Matrix elasticity is one such tailorable property of synthetic scaffolds that is known to differ between tissues.Here,we investigate the interactions between an elastically tailorable polyethylene glycol(PEG)-based hydrogel platform and human bone marrow-derived mesenchymal stem cells(hMSCs).For these studies,two different hydrogel compositions with elastic moduli in the ranges of 50-60 kPa and 8-10 kPa were implemented.Our findings demonstrate that the different elasticities in this platform can produce changes in hMSC morphology and proliferation,indicating that the platform can be implemented to produce changes in hMSC behavior and cell state for a broad range of tissue engineering and regenerative applications.Furthermore,we show that the platform’s different elasticities influence stem cell differentiation potential,particularly when promoting stem cell differentiation toward cell types from tissues with stiffer elasticity.These findings add to the evolving and expanding library of information on stem cell-biomaterial interactions and opens the door for continued exploration into PEG-based hydrogel scaffolds for tissue engineering and regenerative medicine applications. | Anna K.Whitehead Haley H.Barnett Mary E.Caldorera-Moore Jamie J.Newman | 2018 | Regenerative Biomaterials2018，5，3： | 2 |
| 3 | Natural products and drug discovery显示文摘This review covers the recent history of a series of very important natural products and their derivatives that are currently in use or under evaluation in the areas of anti-infectives, important cancer treatments that include antibody drug conjugates, followed by a discussion of type 2 diabetes(T2DM) drugs and angiotensin converting enzyme inhibitors. The current structures of the agents are shown, though in the case of some peptides used in T2DM drugs the standard single leTher abbreviation for an amino acid is used. | David J.Newman | 2022 | National Science Review2022，9，11： | 2 |
| 4 | 空间假频和3-D面元尺寸:寻求更清晰、更低廉数据显示文摘我看到的差不多所有3-D数据集都存在非常严重的假频,这些假频破坏了地震数据的质量。但是,对这个问题有一个简单的解决方法。很多人都知道,面元尺寸选择是根据以下简单公式假频频率=速度/(4×面元大小×sin倾角)该式对一个给定倾角定义了同相轴综合所能包含的最大频率。检查频率的另一个方法是当两道之间的时移超过半个周期时信号出现假频。为了对有倾角的构造进行正确成像,解决地质问题时需要最高频率无假频,则面元的尺寸需要足够小。但是。 | Barry J.Newman 程建春 | 2000 | 国外油气勘探2000，12，5： | 2 |
| 5 | Determaination of Bonding Polymerized Patterns of 13C Specifically Enriched Dehydrogenatively Lignin in Solution and Solid State显示文摘 | N.G.Lewis J.Newman G.Just J.Ripmeister | | 0，，： | 1 |
| 6 | Computational Simulation of Extravehicular Activity Dynamics During a Satellite Capture Attempt显示文摘 | Grant Schaffne Dava J.Newman | | 0，，02： | 1 |
| 7 | Computational Dynamic Analysis of Extravehicular Activity:Large-Mass Handling显示文摘 | Dava J.Newman Grant Schaffner | | 0，，02： | 1 |
| 8 | Porous-Electrode Theory with Battery Applications显示文摘 | J.Newman W.Tiedemann | | 0，，01： | 1 |
| 9 | Preliminary age-based life history characteristics of the dogtooth tuna,Gymnosarda unicolor(Ruppell,1838),in the southwest Pacific Ocean显示文摘Dogtooth tuna,Gymnosarda unicolor were sampled off the east coast of Australia(southwest Pacific Ocean)from 2007 to 2012.Ages were determined by examining thin transverse sections of their sagittal otoliths and were based on counts of alternating opaque and translucent zones(annual growth increments).Growth was rapid during the first year of life,after which growth in length was much reduced.Parameters of the constrained von Bertalanffy growth function(fork length-at-age)were L∞=1164.77(mm,FL)and K=0.44 year^(-1).Preliminary estimates of longevity indicate a maximum observed age of at least 20 years.There was a high degree of variation in the observed length and age of sexual maturity for G.unicolor.Despite this variation,the size at 50%maturity for female G.unicolor estimated in this study was 713 mm FL(<2 years of age).The diet of G.unicolor is very broad and covers a range of fish species.The life history characteristics of G.unicolor overall,indicate that this species may be somewhat resilient to fishing.However,reports of localised depletions,in association with heavy targeting by sports fishers,low effective population sizes and patchy recruitment indicate that this species is particularly vulnerable to overfishing. | David J.Welch Adam K.Smith Kyne Krusic-Golub Sandra Erdmann Stephen J.Newman | 2023 | Aquaculture and Fisheries2023，8，3： | 0 |
| 10 | 太空探索 前沿播报显示文摘于5月20日在北京召开的第16届'人在太空'国际学术会议可说是一个载人航天的高峰论坛,亦可说是一次关于'人在太空'的新想法、新概念、新思路的碰撞和融合。21世纪探月高潮即将来临,火星征途正在开启,我们的航天装备需要改进吗?航天员会遇到哪些困难,我们该怎样解决,而他们自身应做出怎样的努力?在行星探险和地外生命探索的过程中,只有人类在到达某个地方之前,能够了解自己将会带来的生物污染并能加以控制,航天员的独特能力才是有益的。以此来看,太空环保是人类得以向外探索的道德基石和利益保证,这也是人类必须面临并思索的问题……有意思的话题还有很多,比如航天员如何捆住小行星来进行太空行走,航天员可以有'第二皮肤'吗,太空游客的居住环境该如何设计?航天无疑最需要一个想象的殿堂。这次会议无疑带给我们思维一次强烈的冲击,就让我们站在各国航天专家的肩膀上,看得更高,梦得更远,让我们儿时就憧憬的航天之梦沿着科学的轨迹飞翔…… | 丁柏 李莹辉 R.A.Scheuring Thomas Dirlich Noreen Khan-Mayberry Naomi Katayama Baranov Victor Horneck Gerda Dietrich Manzey Tamas Haidegger Leena Tomi Rothschild Lynn Catharine A.Conley Ian Garrick-Bethell Dava J.Newman Vera Martinez Dott.Arch | 2007 | 航天员2007，0，4： | 0 |
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